Quantitative Genetics of Postponed Aging in Drosophila Melanogaster. I. Analysis of Outbred Populations (original) (raw)

Abstract

Selection has been used to create replicated outbred stocks of Drosophila melanogaster with increased longevity, increased later fecundity, and increased levels of physiological performance at later ages. The present study analyzed the quantitative transmission patterns of such stocks, employing extensive replication in numbers of stocks, individuals, and assayed characters. The populations used derived from five lines with postponed aging and five control lines, all created in 1980 from the same founding base population. The following characters were studied: early 24-hr fecundity, early ovary weight, early female starvation resistance, early male starvation resistance, female longevity and male longevity. Numerous crosses were performed to test for non-Mendelian inheritance, average dominance, maternal effects, sex-linkage and between-line heterogeneity. There was only slight evidence for any of these phenomena arising reproducibly in the characters studied. These findings suggest the value of this set of stocks for studies of the physiological basis of postponed aging.

Full Text

The Full Text of this article is available as a PDF (748.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clare M. J., Luckinbill L. S. The effects of gene-environment interaction on the expression of longevity. Heredity (Edinb) 1985 Aug;55(Pt 1):19–26. doi: 10.1038/hdy.1985.67. [DOI] [PubMed] [Google Scholar]
  2. Friedman D. B., Johnson T. E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988 Jan;118(1):75–86. doi: 10.1093/genetics/118.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hutchinson E. W., Shaw A. J., Rose M. R. Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines. Genetics. 1991 Apr;127(4):729–737. doi: 10.1093/genetics/127.4.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Johnson T. E. Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3777–3781. doi: 10.1073/pnas.84.11.3777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lints F. A., Hoste C. The Lansing effect revisited. I. Life-span. Exp Gerontol. 1974 Apr;9(2):51–69. doi: 10.1016/0531-5565(74)90008-4. [DOI] [PubMed] [Google Scholar]
  6. Lints F. A., Stoll J., Gruwez G., Lints C. V. An attempt to select for increased longevity in Drosophila melanogaster. Gerontology. 1979;25(4):192–204. doi: 10.1159/000212340. [DOI] [PubMed] [Google Scholar]
  7. Luckinbill L. S., Clare M. J. Selection for life span in Drosophila melanogaster. Heredity (Edinb) 1985 Aug;55(Pt 1):9–18. doi: 10.1038/hdy.1985.66. [DOI] [PubMed] [Google Scholar]
  8. Luckinbill L. S., Graves J. L., Reed A. H., Koetsawang S. Localizing genes that defer senescence in Drosophila melanogaster. Heredity (Edinb) 1988 Jun;60(Pt 3):367–374. doi: 10.1038/hdy.1988.54. [DOI] [PubMed] [Google Scholar]
  9. Roberts P. A., Iredale R. B. Can mutagenesis reveal major genes affecting senescence? Exp Gerontol. 1985;20(2):119–121. doi: 10.1016/0531-5565(85)90047-6. [DOI] [PubMed] [Google Scholar]
  10. Rose M. R., Charlesworth B. Genetics of life history in Drosophila melanogaster. I. Sib analysis of adult females. Genetics. 1981 Jan;97(1):173–186. doi: 10.1093/genetics/97.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rose M. R., Charlesworth B. Genetics of life history in Drosophila melanogaster. II. Exploratory selection experiments. Genetics. 1981 Jan;97(1):187–196. doi: 10.1093/genetics/97.1.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wattiaux J. M. Parental age effects in Drosophila pseudoobscura. Exp Gerontol. 1968 Mar;3(1):55–61. doi: 10.1016/0531-5565(68)90056-9. [DOI] [PubMed] [Google Scholar]
  13. Weber K. E., Diggins L. T. Increased selection response in larger populations. II. Selection for ethanol vapor resistance in Drosophila melanogaster at two population sizes. Genetics. 1990 Jul;125(3):585–597. doi: 10.1093/genetics/125.3.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Weber K. E. Increased selection response in larger populations. I. Selection for wing-tip height in Drosophila melanogaster at three population sizes. Genetics. 1990 Jul;125(3):579–584. doi: 10.1093/genetics/125.3.579. [DOI] [PMC free article] [PubMed] [Google Scholar]