Germinal centres and the origin of the B-cell system: II. Germinal centres in the rabbit spleen and popliteal lymph nodes (original) (raw)

. 1974 Mar;26(3):509–519.

Abstract

In the preceding paper a population of lymphoid cells was identified which (1) were derived from germinal centres in the appendix, (2) were localized in follicular structures elsewhere, and (3) could perform as antibody-forming cell precursors.

The present paper presents evidence (1) that germinal centres in the spleen and lymph nodes perform the same function as germinal centres in the appendix, and (2) that germinal centres are dependent upon a stream of cells derived from the bone marrow.

A new hypothesis is put forward regarding the origin and cellular kinetics of the B-cell system in mammals. It is proposed that germinal centres throughout the body function as an essentially antigen-dependent amplification system for the B-cell population of lymphocytes. Implications of this hypothesis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper M. D., Perey D. Y., Gabrielsen A. E., Sutherland D. E., McKneally M. F., Good R. A. Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues. Int Arch Allergy Appl Immunol. 1968;33(1):65–88. doi: 10.1159/000229975. [DOI] [PubMed] [Google Scholar]
  2. Cooper M. D., Perey D. Y., McKneally M. F., Gabrielsen A. E., Sutherland D. E., Good R. A. A mammalian equivalent of the avian bursa of Fabricius. Lancet. 1966 Jun 25;1(7452):1388–1391. doi: 10.1016/s0140-6736(66)90300-x. [DOI] [PubMed] [Google Scholar]
  3. FLIEDNER T., KESSE M., CRONKITE E. P., ROBERTSON J. S. CELL PROLIFERATION IN GERMINAL CENTERS OF THE RAT SPLEEN. Ann N Y Acad Sci. 1964 Feb 28;113:578–594. doi: 10.1111/j.1749-6632.1964.tb40692.x. [DOI] [PubMed] [Google Scholar]
  4. Gutman G. A., Weissman I. L. Lymphoid tissue architecture. Experimental analysis of the origin and distribution of T-cells and B-cells. Immunology. 1972 Oct;23(4):465–479. [PMC free article] [PubMed] [Google Scholar]
  5. Howard J. C., Hunt S. V., Gowans J. L. Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats. J Exp Med. 1972 Feb 1;135(2):200–219. doi: 10.1084/jem.135.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mitchell G. F., Miller J. F. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med. 1968 Oct 1;128(4):821–837. doi: 10.1084/jem.128.4.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Nieuwenhuis P., van Nouhuijs C. E., Eggens J. H., Keuning F. J. Germinal centres and the origin of the B-cell system. I. Germinal centres in the rabbit appendix. Immunology. 1974 Mar;26(3):497–507. [PMC free article] [PubMed] [Google Scholar]
  8. Wakefield J. D., Thorbecke G. J. Relationship of germinal centers in lymphoid tissue to immunological memory. I. Evidence for the formation of small lymphocytes upon transfer of primed splenic white pulp to syngeneic mice. J Exp Med. 1968 Jul 1;128(1):153–169. doi: 10.1084/jem.128.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]