Studies on hyperlymphoid mice (original) (raw)

. 1979 Sep;38(1):163–171.

Abstract

Injection of syngeneic, but chromosomally distinguishable, lymph node or spleen cells into adult mice resulted in both T- and B-lymphocyte chimaerism. In spleen-injected mice haematopoietic chimaerism was also established. It appeared that the donor T lymphocytes were added to the host recirculating T-cell pool so that a hyperlymphoid state was produced. The percentage of donor T lymphocytes declined very slowly in normal mice, but remained stable in adult-thymectomized animals. There was no evidence of a homeostatic mechanism involving destruction of excess peripheral T lymphocytes or grossly affecting the flow of T lymphocytes from the thymus into the recirculating T-cell pool. A preliminary model of the T-lymphocyte system is proposed.

163

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryant B. J. Renewal and fate in the mammalian thymus: mechanisms and inferences of thymocytokinetics. Eur J Immunol. 1972 Feb;2(1):38–45. doi: 10.1002/eji.1830020109. [DOI] [PubMed] [Google Scholar]
  2. Davies A. J., Leuchars E., Wallis V., Koller P. C. The mitotic response of thymus-derived cells to antigenic stimulus. Transplantation. 1966 Jul;4(4):438–451. doi: 10.1097/00007890-196607000-00008. [DOI] [PubMed] [Google Scholar]
  3. HARRIS J. E., FORD C. E. CELLULAR TRAFFIC OF THE THYMUS: EXPERIMENTS WITH CHROMOSOME MARKERS. EVIDENCE THAT THE THYMUS PLAYS AN INSTRUCTIONAL PART. Nature. 1964 Feb 29;201:884–885. doi: 10.1038/201884a0. [DOI] [PubMed] [Google Scholar]
  4. Harris G., Olsen I. Cell division and deoxyribonucleic acid (DNA) synthesis in cultures of stimulated lymphocytes. Immunology. 1976 Aug;31(2):195–204. [PMC free article] [PubMed] [Google Scholar]
  5. Jandinski J., Cantor H., Tadakuma T., Peavy D. L., Pierce C. W. Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1382–1390. doi: 10.1084/jem.143.6.1382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kerbel R. S., Elliott E. V., Wallis V. J. Assessment of mitotic thymus-derived lymphocytes by their sensitivity to the cytotoxic effects of anti-theta serum. Cell Immunol. 1974 Mar 30;11(1-3):146–161. doi: 10.1016/0008-8749(74)90015-x. [DOI] [PubMed] [Google Scholar]
  7. Michalke W. D., Hess M. W., Riedwyl H. H., Stoner R. D., Cottier H. Thymic lymphopoiesis and cell loss in newborn mice. Blood. 1969 Apr;33(4):541–554. [PubMed] [Google Scholar]
  8. Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
  9. Shortman K., Von Boehmer H., Lipp J., Hopper K. Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes. Transplant Rev. 1975;25:163–210. [PubMed] [Google Scholar]
  10. Sprent J., Basten A. Circulating T and B lymphocytes of the mouse. II. Lifespan. Cell Immunol. 1973 Apr;7(1):40–59. doi: 10.1016/0008-8749(73)90181-0. [DOI] [PubMed] [Google Scholar]
  11. Sprent J. Circulating T and B lymphocytes of the mouse. I. Migratory properties. Cell Immunol. 1973 Apr;7(1):10–39. doi: 10.1016/0008-8749(73)90180-9. [DOI] [PubMed] [Google Scholar]
  12. Stobo J. D. Phytohemagglutin and concanavalin A: probes for murine 'T' cell activivation and differentiation. Transplant Rev. 1972;11:60–86. doi: 10.1111/j.1600-065x.1972.tb00046.x. [DOI] [PubMed] [Google Scholar]
  13. Vaughan W. P., McGregor D. D. Lymphopoiesis in the rat. I. The effect of pool size on lymphocyte production. J Cell Physiol. 1972 Aug;80(1):1–12. doi: 10.1002/jcp.1040800102. [DOI] [PubMed] [Google Scholar]
  14. Wallis V. J., Leuchars E., Davies A. J. Studies of hyperthymic mice. II. The influence of thymus grafts on cell flow through the peripheral T-cell pool. Immunology. 1978 Dec;35(6):1037–1043. [PMC free article] [PubMed] [Google Scholar]