Elevated serum levels of a biliary glycoprotein (BGP I) in patients with liver or biliary tract disease (original) (raw)

. 1979 May;36(2):317–325.

Abstract

Human hepatic bile contains a glycoprotein (biliary glycoprotein I, BGP I) which cross-reacts with the carcinoembryonic antigen (CEA). A radioimmunoassay for BGP I was developed. The interference of CEA or 'non-specific cross-reacting antigen' (NCA) in the assay was small. The serum levels of BGP I were determined in healthy subjects, in patients with hepato-biliary diseases and in patients with various infectious or inflammatory disorders. Healthy individuals, including pregnant women, had a serum BGP I concentration of about 0.5-1 mg/l. Diseases of the liver or biliary tract (e.g. hepatitis A or B, cytomegalovirus hepatitis, obstructive jaundice or primary biliary cirrhosis) were associated with elevated serum levels of BGP I, as opposed to infectious diseases not affecting the liver mostly showing values within the normal range. Raised levels of serum BGP I activity may reflect biliary obstruction as a result of interference with normal BGP I secretion to the bile.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bullen A. W., Losowsky M. S., Carter S., Patel S., Neville A. M. Diagnostic usefulness of plasma carcinoembryonic antigen levels in acute and chronic liver disease. Gastroenterology. 1977 Oct;73(4 Pt 1):673–678. [PubMed] [Google Scholar]
  2. Burtin P., Chavanel G., Hirsch-Marie H. Characterization of a second normal antigen that cross-reacts with CEA. J Immunol. 1973 Dec;111(6):1926–1928. [PubMed] [Google Scholar]
  3. Gold P., Freedman S. O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  5. Hammarström S., Troye M., Wahlund G., Svenberg T., Perlmann P. K cell mediated lysis of cultured colon carcinoma and urinary bladder carcinoma cells induced by monospecific antisera against carcinoembryonic antigen (CEA) and two CEA-related normal glycoproteins. Int J Cancer. 1977 Jun 15;19(6):756–766. doi: 10.1002/ijc.2910190604. [DOI] [PubMed] [Google Scholar]
  6. Hägerstrand I., Skude G. Improved electrophoretic resolution of human serum alkaline phsophatase isoenzymes in agarose gel by Triton X-100. Scand J Clin Lab Invest. 1976 Mar;36(2):127–129. doi: 10.1080/00365517609055237. [DOI] [PubMed] [Google Scholar]
  7. Keiding N. R. Intestinal alkaline phosphatase in human lymph and serum. Scand J Clin Lab Invest. 1966;18(2):134–140. doi: 10.3109/00365516609051809. [DOI] [PubMed] [Google Scholar]
  8. Khoo S. K., Mackay I. R. Carcinoembryonic antigen in serum in diseases of the liver and pancreas. J Clin Pathol. 1973 Jul;26(7):470–475. doi: 10.1136/jcp.26.7.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Magnius L. O. Characterization of a new antigen-antibody system associated with hepatitis B. Clin Exp Immunol. 1975 May;20(2):209–216. [PMC free article] [PubMed] [Google Scholar]
  10. Matsuoka Y., Hara M., Takatsu K., Kitagawa M. Presence of antigen related to the carcinoembryonic antigen in feces of normal adults. Gan. 1973 Apr;64(2):203–206. [PubMed] [Google Scholar]
  11. Svenberg T. Carcinoembryonic antigen-like substances of human bile. Isolation and partial characterization. Int J Cancer. 1976 May 15;17(5):588–596. doi: 10.1002/ijc.2910170506. [DOI] [PubMed] [Google Scholar]
  12. Wahren B., Edsmyr F., Zimmerman R. Measurement of urinary CEA-like substance. An aid in management of patients with bladder carcinoma. Cancer. 1975 Oct;36(4):1490–1495. doi: 10.1002/1097-0142(197510)36:4<1490::aid-cncr2820360442>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  13. von Kleist S., Chavanel G., Burtin P. Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2492–2494. doi: 10.1073/pnas.69.9.2492. [DOI] [PMC free article] [PubMed] [Google Scholar]