Hypercholesterolaemia treated by soybean protein diet (original) (raw)

Abstract

After a period of stabilisation on a controlled low lipid low cholesterol diet with animal proteins a group of 16 children with familial hypercholesterolaemia were given a textured soybean protein based diet, with a similar fat composition. All the children had a highly significant reduction in total cholesterol, averaging -21.8% against the baseline after eight weeks. Compliance became less strict afterwards, but more than half of the patients have regularly continued the diet and results have been maintained for one year. Minimal changes were noted in triglyceridaemia and in high density lipoprotein cholesterol concentrations, which showed a slight rise only at the end of treatment. The children's growth during the trial was normal. In view of the psychological difficulties of prescribing treatment with drugs to children with severe hypercholesterolaemia before puberty and of the relative ineffectiveness of standard low lipid diets in this condition the soybean protein diet may offer a satisfactory alternative.

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Selected References

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  1. Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973 May;19(5):476–482. [PubMed] [Google Scholar]
  2. Fernandes J., Dijkhuis-Stoffelsma R., Groot P. H., Grose W. F., Ambagtsheer J. J. The effect of a virtually cholesterol-free, high-linoleic-acid vegetarian diet on serum lipoproteins of children with familial hypercholesterolemia (type II-A). Acta Paediatr Scand. 1981 Sep;70(5):677–682. doi: 10.1111/j.1651-2227.1981.tb05767.x. [DOI] [PubMed] [Google Scholar]
  3. Fernandes J., Dijkhuis-Stoffelsma R., Grose W. F. The effect of cholestyramine on serum lipids and platelet aggregation of hypercholesterolemic children (type II A) while on high linoleic acid diet. Acta Paediatr Scand. 1977 Sep;66(5):621–624. doi: 10.1111/j.1651-2227.1977.tb07958.x. [DOI] [PubMed] [Google Scholar]
  4. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed] [Google Scholar]
  5. Glueck C. J., Fallat R., Tsang R. Pediatric familial type II hyperlipoproteinemia: therapy with diet and cholestyramine resin. Pediatrics. 1973 Nov;52(5):669–679. [PubMed] [Google Scholar]
  6. HAVEL R. J., EDER H. A., BRAGDON J. H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955 Sep;34(9):1345–1353. doi: 10.1172/JCI103182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MacLean W. C., Jr, López de Romaña G., Graham G. G. Wheat-based diets: effect of short-term consumption on serum cholesterol and triglyceride levels in infants. Am J Dis Child. 1977 Oct;131(10):1119–1121. doi: 10.1001/archpedi.1977.02120230065011. [DOI] [PubMed] [Google Scholar]
  8. Oliver M. F. Prevention of coronary heart disease--propaganda, promises, problems, and prospects. Circulation. 1986 Jan;73(1):1–9. doi: 10.1161/01.cir.73.1.1. [DOI] [PubMed] [Google Scholar]
  9. Rose V., Allen D. M., Pearse R. G., Chapell J. Primary hyperlipoproteinemia in childhood and adolescence: identification and treatment of persons at risk for premature atherosclerosis. Can Med Assoc J. 1976 Oct 23;115(8):753-6, 779. [PMC free article] [PubMed] [Google Scholar]
  10. Röschlau P., Bernt E., Gruber W. Enzymatische Bestimmung des Gesamt-Cholesterins im Serum. Z Klin Chem Klin Biochem. 1974 Sep;12(9):403–407. [PubMed] [Google Scholar]
  11. Sirtori C. R., Zucchi-Dentone C., Sirtori M., Gatti E., Descovich G. C., Gaddi A., Cattin L., Da Col P. G., Senin U., Mannarino E. Cholesterol-lowering and HDL-raising properties of lecithinated soy proteins in type II hyperlipidemic patients. Ann Nutr Metab. 1985;29(6):348–357. doi: 10.1159/000176991. [DOI] [PubMed] [Google Scholar]
  12. Tsnag R. C., Glueck C. J., Fallat R. W., Mellies M. Neonatal familial hypercholesterolemia. Am J Dis Child. 1975 Jan;129(1):83–91. [PubMed] [Google Scholar]
  13. Weinberg R. B., Spector M. S. Human apolipoprotein A-IV: displacement from the surface of triglyceride-rich particles by HDL2-associated C-apoproteins. J Lipid Res. 1985 Jan;26(1):26–37. [PubMed] [Google Scholar]