Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. (original) (raw)
- Journal List
- Am J Pathol
- v.151(5); 1997 Nov
- PMC1858069
Am J Pathol. 1997 Nov; 151(5): 1417–1423.
F. Pezzella, U. Pastorino, E. Tagliabue, S. Andreola, G. Sozzi, G. Gasparini, S. Menard, K. C. Gatter, A. L. Harris, S. Fox, M. Buyse, S. Pilotti, M. Pierotti, and F. Rilke
Abstract
Neoplastic growth is usually dependent on blood supply, and it is commonly accepted that this is provided by the formation of new vessels. However, tumors may be able to grow without neovascularization if they find a suitable vascular bed available. We have investigated the pattern of vascularization in a series of 500 primary stage I non-small-cell lung carcinomas. Immunostaining of endothelial cells has highlighted four distinct patterns of vascularization. Three patterns (which we called basal, papillary, and diffuse) have in common the destruction of normal lung and the production of newly formed vessels and stroma. The fourth pattern, which we called alveolar or putative nonangiogenic, was observed in 16% (80/500) of the cases and is characterized by lack of parenchymal destruction and absence of both tumor associated stroma and new vessels. The only vessels present were the ones in the alveolar septa, and their presence highlighted, through the whole tumor, the lung alveoli filled up by the neoplastic cells. This observation suggests that, if an appropriate vascular bed is available, a tumor can exploit it and grows without inducing neo-angiogenesis. This could have implications for strategies aimed at inhibiting tumor growth by vascular targeting or inhibition of angiogenesis.
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- Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971 Nov 18;285(21):1182–1186. [PubMed] [Google Scholar]
- Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst. 1990 Jan 3;82(1):4–6. [PubMed] [Google Scholar]
- Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta. 1990 Jun 1;1032(1):89–118. [PubMed] [Google Scholar]
- Hart IR, Saini A. Biology of tumour metastasis. Lancet. 1992 Jun 13;339(8807):1453–1457. [PubMed] [Google Scholar]
- Ellis LM, Fidler IJ. Angiogenesis and metastasis. Eur J Cancer. 1996 Dec;32A(14):2451–2460. [PubMed] [Google Scholar]
- Weidner N. Tumor angiogenesis: review of current applications in tumor prognostication. Semin Diagn Pathol. 1993 Nov;10(4):302–313. [PubMed] [Google Scholar]
- Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol. 1995 Jul;147(1):9–19. [PMC free article] [PubMed] [Google Scholar]
- Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol. 1995 Mar;13(3):765–782. [PubMed] [Google Scholar]
- Craft PS, Harris AL. Clinical prognostic significance of tumour angiogenesis. Ann Oncol. 1994 Apr;5(4):305–311. [PubMed] [Google Scholar]
- Leedy DA, Trune DR, Kronz JD, Weidner N, Cohen JI. Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma of the tongue. Otolaryngol Head Neck Surg. 1994 Oct;111(4):417–422. [PubMed] [Google Scholar]
- Fontanini G, Bigini D, Vignati S, Basolo F, Mussi A, Lucchi M, Chine S, Angeletti CA, Harris AL, Bevilacqua G. Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol. 1995 Sep;177(1):57–63. [PubMed] [Google Scholar]
- Giatromanolaki A, Koukourakis M, O'Byrne K, Fox S, Whitehouse R, Talbot DC, Harris AL, Gatter KC. Prognostic value of angiogenesis in operable non-small cell lung cancer. J Pathol. 1996 May;179(1):80–88. [PubMed] [Google Scholar]
- Yamazaki K, Abe S, Takekawa H, Sukoh N, Watanabe N, Ogura S, Nakajima I, Isobe H, Inoue K, Kawakami Y. Tumor angiogenesis in human lung adenocarcinoma. Cancer. 1994 Oct 15;74(8):2245–2250. [PubMed] [Google Scholar]
- Yuan A, Yang PC, Yu CJ, Lee YC, Yao YT, Chen CL, Lee LN, Kuo SH, Luh KT. Tumor angiogenesis correlates with histologic type and metastasis in non-small-cell lung cancer. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2157–2162. [PubMed] [Google Scholar]
- Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA. Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet. 1992 Jul 18;340(8812):145–146. [PubMed] [Google Scholar]
- Macchiarini P, Fontanini G, Dulmet E, de Montpreville V, Chapelier AR, Cerrina J, Ladurie FL, Dartevelle PG. Angiogenesis: an indicator of metastasis in non-small cell lung cancer invading the thoracic inlet. Ann Thorac Surg. 1994 Jun;57(6):1534–1539. [PubMed] [Google Scholar]
- Pezzella F, Di Bacco A, Andreola S, Nicholson AG, Pastorino U, Harris AL. Angiogenesis in primary lung cancer and lung secondaries. Eur J Cancer. 1996 Dec;32A(14):2494–2500. [PubMed] [Google Scholar]
- Pastorino U, Andreola S, Tagliabue E, Pezzella F, Incarbone M, Sozzi G, Buyse M, Menard S, Pierotti M, Rilke F. Immunocytochemical markers in stage I lung cancer: relevance to prognosis. J Clin Oncol. 1997 Aug;15(8):2858–2865. [PubMed] [Google Scholar]
- Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC, Mason DY. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol. 1990 Sep;43(9):752–757. [PMC free article] [PubMed] [Google Scholar]
- Martignone S, Pellegrini R, Villa E, Tandon NN, Mastroianni A, Tagliabue E, Ménard S, Colnaghi MI. Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression. Clin Exp Metastasis. 1992 Nov;10(6):379–386. [PubMed] [Google Scholar]
- Pezzella F, Tse AG, Cordell JL, Pulford KA, Gatter KC, Mason DY. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol. 1990 Aug;137(2):225–232. [PMC free article] [PubMed] [Google Scholar]
- Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, Key G, D'Amato L, Sabattini E, Feudale E, et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol. 1993 Oct;171(2):83–98. [PubMed] [Google Scholar]
- Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL. Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol. 1995 Nov;177(3):275–283. [PubMed] [Google Scholar]
- Päkkö P, Risteli J, Risteli L, Autio-Harmainen H. Immunohistochemical evidence that lung carcinomas grow on alveolar basement membranes. Am J Surg Pathol. 1990 May;14(5):464–473. [PubMed] [Google Scholar]
- Carriaga MT, Henson DE. The histologic grading of cancer. Cancer. 1995 Jan 1;75(1 Suppl):406–421. [PubMed] [Google Scholar]
- Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991 Nov;19(5):403–410. [PubMed] [Google Scholar]
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