Autoantibodies in coeliac disease: tissue transglutaminase—guilt by association? (original) (raw)

1Institute of Transplantation Immunology, University of Oslo, Rikshospitalet, Norway.

PMCID: PMC1891617 PMID: 9462222

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Figure 1 .

: Gliadin specific T cells can aid antibody production by tTG specific B cells. B cells with antibodies specific for tTG are likely to be present in all individuals, but are dependent on T cell help to start secreting immunoglobulin and to initiate isotype switching. Complex formation between gliadin and tTG makes gliadin a carrier protein for tTG.