Adrenocortical Activity in Disseminated Malignant Disease in Relation to Prognosis (original) (raw)
- Journal List
- Br J Cancer
- v.24(4); 1970 Dec
- PMC2008721
Br J Cancer. 1970 Dec; 24(4): 719–725.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
Abstract
Adrenocortical activity has been assessed in patients with inoperable carcinoma of the bronchus or with disseminated malignant disease of other organs. The mean basal plasma cortisol level was higher in the former than in the latter and both were higher than the controls. Each had abnormally high midnight levels, particularly those with oat cell carcinoma of the bronchus. After the administration of a single dose of dexamethasone both groups suppressed poorly compared with the controls. Failure to suppress was associated with a poor prognosis.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (733K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BELSKY JL, MARKS LJ. Plasma 17-hydroxycorticosteroid responsiveness to ACTH in patients with bronchogenic carcinoma. Metabolism. 1962 Apr;11:435–442. [PubMed] [Google Scholar]
- IVERSEN HG, HJORT GH. The influence of corticoid steroids on the frequency of spleen metastases in patients with breast cancer. Acta Pathol Microbiol Scand. 1958;44(2):205–212. [PubMed] [Google Scholar]
- Lichter I, Sirett NE. Plasma cortisol levels in lung cancer. Br Med J. 1968 Apr 20;2(5598):154–156. [PMC free article] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. [PMC free article] [PubMed] [Google Scholar]
- WERK EE, Jr, SHOLITON LJ, MARNELL RT. Further studies of adrenocortical function in patients with carcinoma of the lung. Am J Med. 1963 Feb;34:192–212. [PubMed] [Google Scholar]
Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK