VIRAL ONCOLYSIS: INCREASED IMMUNOGENICITY OF HOST CELL ANTIGEN ASSOCIATED WITH INFLUENZA VIRUS (original) (raw)

Abstract

A2G mice could be solidly immunized against the Ehrlich ascites tumor by single intraperitoneal injections of homogenized and lyophilized tumor cells which had been infected with oncolytic strains of influenza A virus. Similar homogenates from noninfected tumor cells were not immunogenic, even when mixed with egg-grown virus. The immunizing principle in viral oncolysates could not be separated from the oncolytic virus by differential centrifugation or adsorption to and elution from red cells. It could be inhibited by antibody raised in rabbits against the egg-grown oncolytic virus. This reaction showed serologic specificity. Thus, the immunogenicity of an oncolysate produced with the WSA strain of neurotropic influenza virus could be inhibited by rabbit anti-WSA, but not by rabbit antibody to the TUR strain of fowl plague virus. Conversely, the immunogenicity of an oncolysate prepared with the TUR strain could be inhibited by rabbit anti-TUR, but not by anti-WSA. When mice were preimmunized (primed) with egg-grown WSA virus, their antitumor response to a later injection of WSA oncolysate was of the anamnestic type. Priming with egg-grown influenza B virus had no such effect. It was concluded that the immunogenicity of certain host cell components was greatly increased by incorporation into the makeup of the oncolytic virus.

Full Text

The Full Text of this article is available as a PDF (910.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKERMANN W. W., KURTZ H. A new host-virus system. Proc Soc Exp Biol Med. 1952 Nov;81(2):421–423. doi: 10.3181/00379727-81-19897. [DOI] [PubMed] [Google Scholar]
  2. COE J. E., SALVIN S. B. THE IMMUNE RESPONSE IN THE PRESENCE OF DELAYED HYPERSENSITIVITY OF CIRCULATING ANTIBODY. J Immunol. 1964 Sep;93:495–510. [PubMed] [Google Scholar]
  3. Cassel W. A., Garrett R. E. Tumor immunity after viral oncolysis. J Bacteriol. 1966 Sep;92(3):792–792. doi: 10.1128/jb.92.3.792-.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dougherty R. M., Di Stefano H. S. Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. Virology. 1966 Aug;29(4):586–595. doi: 10.1016/0042-6822(66)90282-0. [DOI] [PubMed] [Google Scholar]
  5. EATON M. D., LEVINTHAL J. D., SCALA A. R., JEWELL M. L. IMMUNITY AND ANTIBODY FORMATION INDUCED BY INTRAPERITONEAL OR SUBCUTANEOUS INJECTION OF KREBS-2 ASCITES TUMOR CELLS TREATED WITH INFLUENZA VIRUS. J Natl Cancer Inst. 1965 May;34:661–672. [PubMed] [Google Scholar]
  6. FRANCIS T., Jr Influenza: the new acquayantance. Ann Intern Med. 1953 Aug;39(2):203–221. doi: 10.7326/0003-4819-39-2-203. [DOI] [PubMed] [Google Scholar]
  7. Fazekas de St Groth, Webster R. G. Disquisitions on Original Antigenic Sin. II. Proof in lower creatures. J Exp Med. 1966 Sep 1;124(3):347–361. doi: 10.1084/jem.124.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Harboe A., Haukenes G. A uronic and sialic acid free chick allantoic mucopolysaccharide sulphate which combines with influenza virus HI-antibody to host material. 3. A high content in chicken bile, and an inactivating enzyme in chicken faeces. Acta Pathol Microbiol Scand. 1966;68(1):98–102. doi: 10.1111/apm.1966.68.1.98. [DOI] [PubMed] [Google Scholar]
  9. Haukenes G., Harboe A., Mortensson-Egnund K. A uronic and sialic acid free chick allantoic mucopolysaccharide sulphate which combines with influenza virus hi-antibody to host material. 1. Purification of the substance. Acta Pathol Microbiol Scand. 1965;64(4):534–542. doi: 10.1111/apm.1965.64.4.534. [DOI] [PubMed] [Google Scholar]
  10. Isacson P. Myxoviruses and autoimmunity. Prog Allergy. 1967;10:256–292. [PubMed] [Google Scholar]
  11. KATES M., ALLISON A. C., TYRELL D. A., JAMES A. T. Origin of lipids in influenza virus. Cold Spring Harb Symp Quant Biol. 1962;27:293–301. doi: 10.1101/sqb.1962.027.001.027. [DOI] [PubMed] [Google Scholar]
  12. KOPROWSKI H., LOVE R., KOPROWSKA I. Enhancement of susceptibility to viruses in neoplastic tissues. Tex Rep Biol Med. 1957;15(3):559–576. [PubMed] [Google Scholar]
  13. Klein P. A. Antibody-mediated immunity to transplantable tumors following reovirus oncolysis. Pathol Microbiol (Basel) 1967;30(2):222–245. doi: 10.1159/000161662. [DOI] [PubMed] [Google Scholar]
  14. Knight C. A. PRECIPITIN REACTIONS OF HIGHLY PURIFIED INFLUENZA VIRUSES AND RELATED MATERIALS. J Exp Med. 1946 Mar 31;83(4):281–294. [PMC free article] [PubMed] [Google Scholar]
  15. Kosyakov P. N., Rovnova Z. I., Shchavelyova A. P. Neutralization of myxoviruses by anticellular sera. Acta Virol. 1966 May;10(3):218–225. [PubMed] [Google Scholar]
  16. LEVY H. B., SOBER H. A. A simple chromatographic method for preparation of gamma globulin. Proc Soc Exp Biol Med. 1960 Jan;103:250–252. doi: 10.3181/00379727-103-25476. [DOI] [PubMed] [Google Scholar]
  17. LINDENMANN J. IMMUNITY TO TRANSPLANTABLE TUMORS FOLLOWING VIRAL ONCOLYSIS. I. MECHANISM OF IMMUNITY TO EHRLICH ASCITES TUMOR. J Immunol. 1964 Jun;92:912–919. [PubMed] [Google Scholar]
  18. LINDENMANN J., KLEIN P. A. IMMUNITY TO TRANSPLANTABLE TUMORS FOLLOWING VIRAL ONCOLYSIS.II. ANTIGENIC SIMILARITIES BETWEEN THREE UNSPECIFIC MOUSE TUMORS. J Immunol. 1965 Mar;94:461–466. [PubMed] [Google Scholar]
  19. LINDENMANN J., LANE C. A., HOBSON D. THE RESISTANCE OF A2G MICE TO MYXOVIRUSES. J Immunol. 1963 Jun;90:942–951. [PubMed] [Google Scholar]
  20. LINDENMANN J. Viral oncolysis with host survival. Proc Soc Exp Biol Med. 1963 May;113:85–91. doi: 10.3181/00379727-113-28284. [DOI] [PubMed] [Google Scholar]
  21. Laver W. G., Webster R. G. The structure of influenza viruses. IV. Chemical studies of the host antigen. Virology. 1966 Sep;30(1):104–115. doi: 10.1016/s0042-6822(66)81014-0. [DOI] [PubMed] [Google Scholar]
  22. ROWLEY D. A., FITCH F. W. HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT. J Exp Med. 1964 Dec 1;120:987–1005. doi: 10.1084/jem.120.6.987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. SALVIN S. B., SMITH R. F. The specificity of allergic reactions. I. Delayed versus Arthus hypersensitivity. J Exp Med. 1960 Apr 1;111:465–483. doi: 10.1084/jem.111.4.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SMITH W., BELYAVIN G., SHEFFIELD F. W. The host-tissue component of influenza viruses. Proc R Soc Lond B Biol Sci. 1955 May 17;143(913):504–522. doi: 10.1098/rspb.1955.0026. [DOI] [PubMed] [Google Scholar]
  25. Schoyen R., Harboe A., Wang L. Influenza virus HI-antibody combing with normal chick material and produced in hens immunized with chick grown influenza virus. Acta Pathol Microbiol Scand. 1966;68(1):103–107. doi: 10.1111/apm.1966.68.1.103. [DOI] [PubMed] [Google Scholar]
  26. UHR J. W., BAUMANN J. B. Antibody formation. I. The suppression of antibody formation by passively administered antibody. J Exp Med. 1961 May 1;113:935–957. doi: 10.1084/jem.113.5.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. UHR J. W., BAUMANN J. B. Antibody formation. II. The specific anamnestic antibody response. J Exp Med. 1961 May 1;113:959–970. doi: 10.1084/jem.113.5.959. [DOI] [PMC free article] [PubMed] [Google Scholar]