On immunosurveillance in human cancer. (original) (raw)
- Journal List
- Yale J Biol Med
- v.55(3-4); May-Aug 1982
- PMC2596448
Yale J Biol Med. 1982 May-Aug; 55(3-4): 329–333.
Abstract
The extraordinarily high incidence of cancers of many different varieties--carcinomas and lymphomas--in organ-transplant patients being maintained for long periods of time with immunosuppressive drugs is briefly reviewed. The role of immunosurveillance as a primary defense mechanism against cancer in human beings is consistent with these observations and is in need of further investigation. Conceivably, this mechanism may play a somewhat different role in humans from what has been observed in most experimental animal models.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (710K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- North RJ. Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med. 1982 Apr 1;155(4):1063–1074. [PMC free article] [PubMed] [Google Scholar]
- Cahan WG. Multiple primary cancers of the lung, esophagus, and other sites. Cancer. 1977 Oct;40(4 Suppl):1954–1960. [PubMed] [Google Scholar]
- Klein E, Holtermann OA, Helm F, Rosner D, Milgrom H, Adler S, Stoll HL, Jr, Case RW, Prior RL, Murphy GP. Immunologic approaches to the management of primary and secondary tumors involving the skin and soft tissues: review of a ten-year program. Transplant Proc. 1975 Jun;7(2):297–315. [PubMed] [Google Scholar]
- Krikorian JG, Anderson JL, Bieber CP, Penn I, Stinson EB. Malignant neoplasms following cardiac transplantation. JAMA. 1978 Aug 18;240(7):639–643. [PubMed] [Google Scholar]
- Penn I. Development of cancer as a complication of clinical transplantation. Transplant Proc. 1977 Mar;9(1):1121–1127. [PubMed] [Google Scholar]
- Sheil AG, Mahony JF, Horvath JS, Johnson JR, Tiller DJ, Stewart JH, May J. Cancer following successful cadaveric donor renal transplantation. Transplant Proc. 1981 Mar;13(1 Pt 2):733–735. [PubMed] [Google Scholar]
- Zisbrod Z, Haimov M, Schanzer H, Ambinder E, Burrows L. Kaposi's sarcoma after kidney transplantation. Report of complete remission of cutaneous and visceral involvement. Transplantation. 1980 Nov;30(5):383–384. [PubMed] [Google Scholar]
- Spees EK, Jr, Kramer KK, Light JA, Oakes DD, Zimmerman LE. Reactivation of ocular malignant melanoma after renal transplantation. Transplantation. 1980 May;29(5):421–424. [PubMed] [Google Scholar]
- Greenberg AH, Greene M. Non-adaptive rejection of small tumour inocula as a model of immune surveillance. Nature. 1976 Nov 25;264(5584):356–359. [PubMed] [Google Scholar]
- Morris PJ. Cyclosporin A. Transplantation. 1981 Nov;32(5):349–354. [PubMed] [Google Scholar]
Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine