Hundreds of variants clustered in genomic loci and biological pathways affect human height (original) (raw)

Nature. Author manuscript; available in PMC 2011 Apr 14.

Published in final edited form as:

PMCID: PMC2955183

NIHMSID: NIHMS225625

Hana Lango Allen,1,* Karol Estrada,2,3,4,* Guillaume Lettre,5,6,* Sonja I. Berndt,7,* Michael N. Weedon,1,* Fernando Rivadeneira,2,3,4,* Cristen J. Willer,8 Anne U. Jackson,8 Sailaja Vedantam,9,10 Soumya Raychaudhuri,11,12 Teresa Ferreira,13 Andrew R. Wood,1 Robert J. Weyant,8 Ayellet V. Segrè,11,14,15 Elizabeth K. Speliotes,10,16 Eleanor Wheeler,17 Nicole Soranzo,17,18 Ju-Hyun Park,7 Jian Yang,19 Daniel Gudbjartsson,20 Nancy L. Heard-Costa,21 Joshua C. Randall,13 Lu Qi,22,23 Albert Vernon Smith,24,25 Reedik Mägi,13 Tomi Pastinen,26,27,28 Liming Liang,29 Iris M. Heid,30,31 Jian'an Luan,32 Gudmar Thorleifsson,20 Thomas W. Winkler,30 Michael E. Goddard,33,34 Ken Sin Lo,5 Cameron Palmer,9,10 Tsegaselassie Workalemahu,22 Yurii S. Aulchenko,2,4 Åsa Johansson,35,36 M.Carola Zillikens,3 Mary F. Feitosa,37 Tõnu Esko,38,39,40 Toby Johnson,41,42,43,44 Shamika Ketkar,37 Peter Kraft,45,46 Massimo Mangino,18 Inga Prokopenko,13,47 Devin Absher,48 Eva Albrecht,31 Florian Ernst,49 Nicole L. Glazer,50 Caroline Hayward,51 Jouke-Jan Hottenga,52 Kevin B. Jacobs,53 Joshua W. Knowles,54 Zoltán Kutalik,41,42 Keri L. Monda,55 Ozren Polasek,56,57 Michael Preuss,58 Nigel W. Rayner,13,47 Neil R. Robertson,13,47 Valgerdur Steinthorsdottir,20 Jonathan P. Tyrer,59 Benjamin F. Voight,11,14,15 Fredrik Wiklund,60 Jianfeng Xu,61 Jing Hua Zhao,32 Dale R. Nyholt,62 Niina Pellikka,63,64 Markus Perola,63,64 John R.B. Perry,1 Ida Surakka,63,64 Mari-Liis Tammesoo,38 Elizabeth L. Altmaier,9,10 Najaf Amin,2 Thor Aspelund,24,25 Tushar Bhangale,65 Gabrielle Boucher,5 Daniel I. Chasman,66,67 Constance Chen,68 Lachlan Coin,69 Matthew N. Cooper,70 Anna L. Dixon,71 Quince Gibson,72 Elin Grundberg,17,26,27 Ke Hao,73 M. Juhani Junttila,74 Lee M. Kaplan,16,67,75 Johannes Kettunen,63,64 Inke R. König,58 Tony Kwan,26,27 Robert W. Lawrence,70 Douglas F. Levinson,76 Mattias Lorentzon,77 Barbara McKnight,78 Andrew P. Morris,13 Martina Müller,31,79,80 Julius Suh Ngwa,81 Shaun Purcell,14,82,83 Suzanne Rafelt,84 Rany M. Salem,9,10 Erika Salvi,85,86 Serena Sanna,87 Jianxin Shi,7 Ulla Sovio,69 John R. Thompson,88,89 Michael C. Turchin,9,10 Liesbeth Vandenput,77 Dominique J. Verlaan,26,27 Veronique Vitart,51 Charles C. White,81 Andreas Ziegler,90 Peter Almgren,91 Anthony J. Balmforth,92 Harry Campbell,93 Lorena Citterio,94 Alessandro De Grandi,95 Anna Dominiczak,96 Jubao Duan,97 Paul Elliott,69 Roberto Elosua,98 Johan G. Eriksson,99,100,101,102,103 Nelson B. Freimer,104 Eco J.C. Geus,52 Nicola Glorioso,105 Shen Haiqing,72 Anna-Liisa Hartikainen,106 Aki S. Havulinna,107 Andrew A. Hicks,95 Jennie Hui,70,108,109 Wilmar Igl,35 Thomas Illig,31 Antti Jula,110 Eero Kajantie,100 Tuomas O. Kilpeläinen,32 Markku Koiranen,111 Ivana Kolcic,56 Seppo Koskinen,107 Peter Kovacs,112 Jaana Laitinen,113 Jianjun Liu,114 Marja-Liisa Lokki,115 Ana Marusic,116 Andrea Maschio,87 Thomas Meitinger,117,118 Antonella Mulas,87 Guillaume Paré,119 Alex N. Parker,120 John F. Peden,13,121 Astrid Petersmann,122 Irene Pichler,95 Kirsi H. Pietiläinen,123,124 Anneli Pouta,106,125 Martin Ridderstråle,126 Jerome I. Rotter,127 Jennifer G. Sambrook,128,129 Alan R. Sanders,97 Carsten Oliver Schmidt,130 Juha Sinisalo,131 Jan H. Smit,132 Heather M. Stringham,8 G.Bragi Walters,20 Elisabeth Widen,63 Sarah H. Wild,93 Gonneke Willemsen,52 Laura Zagato,94 Lina Zgaga,56 Paavo Zitting,133 Helene Alavere,38 Martin Farrall,13,121,134 Wendy L. McArdle,135 Mari Nelis,38,39,40 Marjolein J. Peters,3,4 Samuli Ripatti,63,64 Joyce B.J. van Meurs,2,3,4 Katja K. Aben,136 Kristin G Ardlie,11 Jacques S. Beckmann,41,137 John P. Beilby,108,109,138 Richard N. Bergman,139 Sven Bergmann,41,42 Francis S. Collins,140 Daniele Cusi,85 Martin den Heijer,141 Gudny Eiriksdottir,24 Pablo V. Gejman,97 Alistair S. Hall,92 Anders Hamsten,142 Heikki V. Huikuri,74,74 Carlos Iribarren,143,144 Mika Kähönen,145 Jaakko Kaprio,63,123,146 Sekar Kathiresan,11,14,147,148,149 Lambertus Kiemeney,136,150,151 Thomas Kocher,152 Lenore J. Launer,153 Terho Lehtimäki,154 Olle Melander,126 Tom H. Mosley, Jr,155 Arthur W. Musk,109,156 Markku S. Nieminen,131,131 Christopher J. O'Donnell,148,157 Claes Ohlsson,77 Ben Oostra,158 Lyle J. Palmer,70,109 Olli Raitakari,159 Paul M. Ridker,66,67 John D. Rioux,5,6 Aila Rissanen,124 Carlo Rivolta,41 Heribert Schunkert,160 Alan R. Shuldiner,72,161 David S. Siscovick,162,163 Michael Stumvoll,164,165 Anke Tönjes,164,166 Jaakko Tuomilehto,167,168,169 Gert-Jan van Ommen,170 Jorma Viikari,171 Andrew C. Heath,172 Nicholas G. Martin,173 Grant W. Montgomery,174 Michael A. Province,37,175 Manfred Kayser,176 Alice M. Arnold,78,177 Larry D. Atwood,21 Eric Boerwinkle,178 Stephen J. Chanock,7 Panos Deloukas,17 Christian Gieger,31 Henrik Grönberg,60 Per Hall,60 Andrew T. Hattersley,1 Christian Hengstenberg,179,180 Wolfgang Hoffman,130 G.Mark Lathrop,181 Veikko Salomaa,107 Stefan Schreiber,182 Manuela Uda,87 Dawn Waterworth,183 Alan F. Wright,51 Themistocles L. Assimes,54 Inês Barroso,17,184 Albert Hofman,2,4 Karen L. Mohlke,185 Dorret I. Boomsma,52 Mark J. Caulfield,44 L.Adrienne Cupples,81 Jeanette Erdmann,160 Caroline S. Fox,186 Vilmundur Gudnason,24,25 Ulf Gyllensten,35 Tamara B. Harris,153 Richard B. Hayes,187 Marjo-Riitta Jarvelin,69,111,125,188 Vincent Mooser,183 Patricia B. Munroe,44 Willem H. Ouwehand,17,128,129 Brenda W. Penninx,132,189,190 Peter P. Pramstaller,95,191,192 Thomas Quertermous,54 Igor Rudan,51,116 Nilesh J. Samani,84,88 Timothy D. Spector,18 Henry Völzke,130 Hugh Watkins,13,121, Procardis Consortium James F. Wilson,93 Leif C. Groop,91 Talin Haritunians,127 Frank B. Hu,22,23,45 Robert C. Kaplan,193 Andres Metspalu,38,39,40 Kari E. North,55,194 David Schlessinger,195 Nicholas J. Wareham,32 David J. Hunter,22,23,45 Jeffrey R. O'Connell,72 David P. Strachan,196 H.-Erich Wichmann,31,80,197 Ingrid B. Borecki,37,175 Cornelia M. van Duijn,2,4 Eric E. Schadt,198,199 Unnur Thorsteinsdottir,20,200 Leena Peltonen,17,63,64,82,201 André Uitterlinden,2,3,4 Peter M. Visscher,19 Nilanjan Chatterjee,7 Ruth J.F. Loos,32 Michael Boehnke,8 Mark I. McCarthy,13,47,202 Erik Ingelsson,60 Cecilia M. Lindgren,13,47 Gonçalo R. Abecasis,8,* Kari Stefansson,20,200,* Timothy M. Frayling,1,* and Joel N Hirschhorn9,10,203,*, for the GIANT Consortium

Hana Lango Allen

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Karol Estrada

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Guillaume Lettre

5 Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

6 Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada

Sonja I. Berndt

7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA

Michael N. Weedon

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Fernando Rivadeneira

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Cristen J. Willer

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

Anne U. Jackson

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

Sailaja Vedantam

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

Soumya Raychaudhuri

11 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

12 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA

Teresa Ferreira

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

Andrew R. Wood

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Robert J. Weyant

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

Ayellet V. Segrè

11 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

14 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

15 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Elizabeth K. Speliotes

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

16 Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Eleanor Wheeler

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

Nicole Soranzo

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

18 Department of Twin Research and Genetic Epidemiology, King's College London, Lambeth Palace Rd, London, SE1 7EH, UK

Ju-Hyun Park

7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA

Jian Yang

19 Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia

Daniel Gudbjartsson

20 deCODE Genetics, 101 Reykjavik, Iceland

Nancy L. Heard-Costa

21 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA

Joshua C. Randall

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

Lu Qi

22 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA

23 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

Find articles by Lu Qi

Albert Vernon Smith

24 Icelandic Heart Association, Kopavogur, Iceland

25 University of Iceland, Reykjavik, Iceland

Reedik Mägi

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

Tomi Pastinen

26 McGill University and Genome Québec Innovation Centre, Montréal, Québec H3A 1A4, Canada

27 Department of Human Genetics, McGill University Health Centre, McGill University, Montréal, Québec H3G 1A4, Canada

28 Department of Medical Genetics, McGill University Health Centre, McGill University, Montréal, Québec H3G 1A4, Canada

Liming Liang

29 Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02138, USA

Iris M. Heid

30 Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

Jian'an Luan

32 MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK

Gudmar Thorleifsson

20 deCODE Genetics, 101 Reykjavik, Iceland

Thomas W. Winkler

30 Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, 93053 Regensburg, Germany

Michael E. Goddard

33 University of Melbourne, Parkville 3010, Australia

34 Department of Primary Industries, Melbourne, Victoria 3001, Australia

Ken Sin Lo

5 Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

Cameron Palmer

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

Tsegaselassie Workalemahu

22 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA

Yurii S. Aulchenko

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Åsa Johansson

35 Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden

36 Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, N-7489, Norway

M.Carola Zillikens

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

Mary F. Feitosa

37 Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA

Tõnu Esko

38 Estonian Genome Center, University of Tartu, Tartu 50410, Estonia

39 Estonian Biocenter, Tartu 51010, Estonia

40 Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia

Toby Johnson

41 Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland

42 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

43 Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK

44 Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

Shamika Ketkar

37 Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA

Peter Kraft

45 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA

46 Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA

Massimo Mangino

18 Department of Twin Research and Genetic Epidemiology, King's College London, Lambeth Palace Rd, London, SE1 7EH, UK

Inga Prokopenko

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

47 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK

Devin Absher

48 Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA

Eva Albrecht

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

Florian Ernst

49 Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany

Nicole L. Glazer

50 Cardiovascular Health Resarch Unit and Department of Medicine, University of Washington, Seattle, Washington 98101, USA

Caroline Hayward

51 MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK

Jouke-Jan Hottenga

52 Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands

Kevin B. Jacobs

53 Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA

Joshua W. Knowles

54 Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA

Zoltán Kutalik

41 Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland

42 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

Keri L. Monda

55 Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514 USA

Ozren Polasek

56 Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia

57 Gen-Info Ltd, 10000 Zagreb, Croatia

Michael Preuss

58 Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik, 23562 Lübeck, Germany

Nigel W. Rayner

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

47 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK

Neil R. Robertson

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

47 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK

Valgerdur Steinthorsdottir

20 deCODE Genetics, 101 Reykjavik, Iceland

Jonathan P. Tyrer

59 Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK

Benjamin F. Voight

11 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

14 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

15 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Fredrik Wiklund

60 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

Jianfeng Xu

61 Center for Human Genomics, Wake Forest University, Winston-Salem, North Carolina 27157, USA

Jing Hua Zhao

32 MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK

Dale R. Nyholt

62 Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia

Niina Pellikka

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

Markus Perola

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

John R.B. Perry

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Ida Surakka

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

Mari-Liis Tammesoo

38 Estonian Genome Center, University of Tartu, Tartu 50410, Estonia

Elizabeth L. Altmaier

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

Najaf Amin

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

Thor Aspelund

24 Icelandic Heart Association, Kopavogur, Iceland

25 University of Iceland, Reykjavik, Iceland

Tushar Bhangale

65 Department of Genome Sciences, University of Washington, Seattle, 98195 Washington, USA

Gabrielle Boucher

5 Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

Daniel I. Chasman

66 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA

67 Harvard Medical School, Boston, Massachusetts 02115, USA

Constance Chen

68 Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA

Lachlan Coin

69 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK

Matthew N. Cooper

70 Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia

Anna L. Dixon

71 Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, BA1 1RL, UK

Quince Gibson

72 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA

Elin Grundberg

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

26 McGill University and Genome Québec Innovation Centre, Montréal, Québec H3A 1A4, Canada

27 Department of Human Genetics, McGill University Health Centre, McGill University, Montréal, Québec H3G 1A4, Canada

Ke Hao

73 Genetics Department, Rosetta Inpharmatics, a Wholly Owned Subsidiary of Merck & Co. Inc., Seattle, Washington 98109, USA

M. Juhani Junttila

74 Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland

Lee M. Kaplan

16 Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

67 Harvard Medical School, Boston, Massachusetts 02115, USA

75 MGH Weight Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Johannes Kettunen

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

Inke R. König

58 Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik, 23562 Lübeck, Germany

Tony Kwan

26 McGill University and Genome Québec Innovation Centre, Montréal, Québec H3A 1A4, Canada

27 Department of Human Genetics, McGill University Health Centre, McGill University, Montréal, Québec H3G 1A4, Canada

Robert W. Lawrence

70 Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia

Douglas F. Levinson

76 Stanford University School of Medicine, Stanford, California 93405, USA

Mattias Lorentzon

77 Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden

Barbara McKnight

78 Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA

Andrew P. Morris

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

Martina Müller

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

79 Ludwig-Maximilians-University, Department of Medicine I, University Hospital Grosshadern, 81377 Munich, Germany

80 Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany

Julius Suh Ngwa

81 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA

Shaun Purcell

14 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

82 The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA

83 Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA

Suzanne Rafelt

84 Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK

Rany M. Salem

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

Erika Salvi

85 University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy

86 KOS Genetic Srl, 20123 Milan, Italy

Serena Sanna

87 Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy

Jianxin Shi

7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA

Ulla Sovio

69 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK

John R. Thompson

88 Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK

89 Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, UK

Michael C. Turchin

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

Liesbeth Vandenput

77 Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden

Dominique J. Verlaan

26 McGill University and Genome Québec Innovation Centre, Montréal, Québec H3A 1A4, Canada

27 Department of Human Genetics, McGill University Health Centre, McGill University, Montréal, Québec H3G 1A4, Canada

Veronique Vitart

51 MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK

Charles C. White

81 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA

Andreas Ziegler

90 Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik, 23562 Lübeck, Germany

Peter Almgren

91 Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden

Anthony J. Balmforth

92 Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK

Harry Campbell

93 Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland

Lorena Citterio

94 University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy

Alessandro De Grandi

95 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck, Lübeck, Germany

Anna Dominiczak

96 British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, UK

Jubao Duan

97 Northshore University Healthsystem, Evanston, Ilinois 60201, USA

Paul Elliott

69 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK

Roberto Elosua

98 Cardiovascular Epidemiology and Genetics, Institut Municipal D'investigacio Medica and CIBER Epidemiología y Salud Pública, Barcelona, Spain

Johan G. Eriksson

99 Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland

100 National Institute for Health and Welfare, 00271 Helsinki, Finland

101 Helsinki University Central Hospital, Unit of General Practice, 00280 Helsinki, Finland

102 Folkhalsan Research Centre, 00250 Helsinki, Finland

103 Vasa Central Hospital, 65130 Vasa, Finland

Nelson B. Freimer

104 Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA

Eco J.C. Geus

52 Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands

Nicola Glorioso

105 Hypertension and Cardiovascular Prevention Center, University of Sassari, 07100 Sassari, Italy

Shen Haiqing

72 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA

Anna-Liisa Hartikainen

106 Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland

Aki S. Havulinna

107 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland

Andrew A. Hicks

95 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck, Lübeck, Germany

Jennie Hui

70 Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia

108 PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia

109 Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia

Wilmar Igl

35 Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden

Thomas Illig

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

Antti Jula

110 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, 20720 Turku, Finland

Eero Kajantie

100 National Institute for Health and Welfare, 00271 Helsinki, Finland

Tuomas O. Kilpeläinen

32 MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK

Markku Koiranen

111 Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland

Ivana Kolcic

56 Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia

Seppo Koskinen

107 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland

Peter Kovacs

112 Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany

Jaana Laitinen

113 Finnish Institute of Occupational Health, 90220 Oulu, Finland

Jianjun Liu

114 Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore

Marja-Liisa Lokki

115 Transplantation Laboratory, Haartman Institute, University of Helsinki, 00014, Helsinki, Finland

Ana Marusic

116 Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia

Andrea Maschio

87 Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy

Thomas Meitinger

117 Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, 81675 Munich, Germany

118 Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

Antonella Mulas

87 Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy

Guillaume Paré

119 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N3Z5, Canada

Alex N. Parker

120 Amgen, Cambridge, Massachusetts 02139, USA

John F. Peden

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

121 Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU

Astrid Petersmann

122 Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald, 17475 Greifswald, Germany

Irene Pichler

95 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck, Lübeck, Germany

Kirsi H. Pietiläinen

123 Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland

124 Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland

Anneli Pouta

106 Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland

125 National Institute for Health and Welfare, 90101 Oulu, Finland

Martin Ridderstråle

126 Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden

Jerome I. Rotter

127 Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

Jennifer G. Sambrook

128 Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK

129 NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK

Alan R. Sanders

97 Northshore University Healthsystem, Evanston, Ilinois 60201, USA

Carsten Oliver Schmidt

130 Institut für Community Medicine, 17489 Greifswald, Germany

Juha Sinisalo

131 Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland

Jan H. Smit

132 Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands

Heather M. Stringham

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

G.Bragi Walters

20 deCODE Genetics, 101 Reykjavik, Iceland

Elisabeth Widen

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

Sarah H. Wild

93 Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland

Gonneke Willemsen

52 Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands

Laura Zagato

94 University Vita-Salute San Raffaele, Division of Nephrology and Dialysis, 20132 Milan, Italy

Lina Zgaga

56 Andrija Stampar School of Public Health, Medical School, University of Zagreb, 10000 Zagreb, Croatia

Paavo Zitting

133 Department of Psychiatrics, Lapland Central Hospital, 96101 Rovaniemi, Finland

Helene Alavere

38 Estonian Genome Center, University of Tartu, Tartu 50410, Estonia

Martin Farrall

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

121 Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU

134 Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK

Wendy L. McArdle

135 Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN, UK

Mari Nelis

38 Estonian Genome Center, University of Tartu, Tartu 50410, Estonia

39 Estonian Biocenter, Tartu 51010, Estonia

40 Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia

Marjolein J. Peters

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Samuli Ripatti

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

Joyce B.J. van Meurs

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Katja K. Aben

136 Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands

Kristin G Ardlie

11 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

Jacques S. Beckmann

41 Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland

137 Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland

John P. Beilby

108 PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, Nedlands, Western Australia 6009, Australia

109 Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia

138 School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia

Richard N. Bergman

139 Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA

Sven Bergmann

41 Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland

42 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

Francis S. Collins

140 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

Daniele Cusi

85 University of Milan, Department of Medicine, Surgery and Dentistry, 20139 Milano, Italy

Martin den Heijer

141 Department of Endocrinology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands

Gudny Eiriksdottir

24 Icelandic Heart Association, Kopavogur, Iceland

Pablo V. Gejman

97 Northshore University Healthsystem, Evanston, Ilinois 60201, USA

Alistair S. Hall

92 Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK

Anders Hamsten

142 Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden

Heikki V. Huikuri

74 Department of Internal Medicine, University of Oulu, 90014 Oulu, Finland

Carlos Iribarren

143 Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA

144 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA

Mika Kähönen

145 Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland

Jaakko Kaprio

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

123 Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00014, Helsinki, Finland

146 National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Unit for Child and Adolescent Mental Health, 00271 Helsinki, Finland

Sekar Kathiresan

11 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

14 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

147 Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

148 Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA

149 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA

Lambertus Kiemeney

136 Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands

150 Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands

151 Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands

Thomas Kocher

152 Zentrum für Zahn-, Mund- und Kieferheilkunde, 17489 Greifswald, Germany

Lenore J. Launer

153 Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA

Terho Lehtimäki

154 Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland

Olle Melander

126 Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden

Tom H. Mosley, Jr

155 Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA

Arthur W. Musk

109 Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia

156 School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia

Markku S. Nieminen

131 Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, 00029 Helsinki, Finland

Christopher J. O'Donnell

148 Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA

157 National, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts 01702, USA

Claes Ohlsson

77 Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden

Ben Oostra

158 Department of Clinical Genetics, Erasmus MC, Rotterdam, 3015GE, The Netherlands

Lyle J. Palmer

70 Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia 6009, Australia

109 Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia

Olli Raitakari

159 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and the Department of Clinical Physiology, Turku University Hospital, 20520 Turku, Finland

Paul M. Ridker

66 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA

67 Harvard Medical School, Boston, Massachusetts 02115, USA

John D. Rioux

5 Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

6 Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada

Aila Rissanen

124 Obesity Research unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland

Carlo Rivolta

41 Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland

Heribert Schunkert

160 Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany

Alan R. Shuldiner

72 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA

161 Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland 21201, USA

David S. Siscovick

162 Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA

163 Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA

Michael Stumvoll

164 Department of Medicine, University of Leipzig, 04103 Leipzig, Germany

165 LIFE Study Centre, University of Leipzig, Leipzig, Germany

Anke Tönjes

164 Department of Medicine, University of Leipzig, 04103 Leipzig, Germany

166 Coordination Centre for Clinical Trials, University of Leipzig, Härtelstr. 16-18, 04103 Leipzig, Germany

Jaakko Tuomilehto

167 National Institute for Health and Welfare, Diabetes Prevention Unit, 00271 Helsinki, Finland

168 Hjelt Institute, Department of Public Health, University of Helsinki, 00014 Helsinki, Finland

169 South Ostrobothnia Central Hospital, 60220 Seinajoki, Finland

Gert-Jan van Ommen

170 Department of Human Genetics and Center of Medical Systems Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands

Jorma Viikari

171 Department of Medicine, University of Turku and Turku University Hospital, 20520 Turku, Finland

Andrew C. Heath

172 Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA

Nicholas G. Martin

173 Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia

Grant W. Montgomery

174 Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia

Michael A. Province

37 Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA

175 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA

Manfred Kayser

176 Department of Forensic Molecular Biology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

Alice M. Arnold

78 Departments of Biostatistics, University of Washington, Seattle, Washington 98195, USA

177 Collaborative Health Studies Coordinating Center, Seattle, Washington 98115, USA

Larry D. Atwood

21 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA

Eric Boerwinkle

178 Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, Texas 77030, USA

Stephen J. Chanock

7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA

Panos Deloukas

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

Christian Gieger

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

Henrik Grönberg

60 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

Per Hall

60 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

Andrew T. Hattersley

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Christian Hengstenberg

179 Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, 93053 Regensburg, Germany

180 Regensburg University Medical Center, Innere Medizin II, 93053 Regensburg, Germany

Wolfgang Hoffman

130 Institut für Community Medicine, 17489 Greifswald, Germany

G.Mark Lathrop

181 Centre National de Genotypage, Evry, Paris 91057, France

Veikko Salomaa

107 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit, 00014, Helsinki, Finland

Stefan Schreiber

182 Christian-Albrechts-University, University Hospital Schleswig-Holstein, Institute for Clinical Molecular Biology and Department of Internal Medicine I, Schittenhelmstrasse 12, 24105 Kiel

Manuela Uda

87 Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042, Cagliari, Italy

Dawn Waterworth

183 Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA

Alan F. Wright

51 MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK

Themistocles L. Assimes

54 Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA

Inês Barroso

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

184 University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke's Hospital, CB2 OQQ, Cambridge, UK

Albert Hofman

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Karen L. Mohlke

185 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA

Dorret I. Boomsma

52 Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands

Mark J. Caulfield

L.Adrienne Cupples

81 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA

Jeanette Erdmann

160 Universität zu Lübeck, Medizinische Klinik II, 23562 Lübeck, Germany

Caroline S. Fox

186 Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts 01702, USA

Vilmundur Gudnason

24 Icelandic Heart Association, Kopavogur, Iceland

25 University of Iceland, Reykjavik, Iceland

Ulf Gyllensten

35 Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden

Tamara B. Harris

153 Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA

Richard B. Hayes

187 New York University Medical Center, New York, New York 10016, USA

Marjo-Riitta Jarvelin

69 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK

111 Institute of Health Sciences, University of Oulu, 90014 Oulu, Finland

125 National Institute for Health and Welfare, 90101 Oulu, Finland

188 Biocenter Oulu, University of Oulu, 90014 Oulu, Finland

Vincent Mooser

183 Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA

Patricia B. Munroe

Willem H. Ouwehand

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

128 Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK

129 NHS Blood and Transplant, Cambridge Centre, Cambridge, CB2 0PT, UK

Brenda W. Penninx

132 Department of Psychiatry/EMGO Institute, VU University Medical Center, 1081 BT Amsterdam, The Netherlands

189 Department of Psychiatry, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands

190 Department of Psychiatry, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands

Peter P. Pramstaller

95 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck, Lübeck, Germany

191 Department of Neurology, General Central Hospital, Bolzano, Italy

192 Department of Neurology, University of Lübeck, Lübeck, Germany

Thomas Quertermous

54 Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA

Igor Rudan

51 MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK

116 Croatian Centre for Global Health, School of Medicine, University of Split, Split 21000, Croatia

Nilesh J. Samani

84 Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK

88 Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, LE3 9QP, UK

Timothy D. Spector

18 Department of Twin Research and Genetic Epidemiology, King's College London, Lambeth Palace Rd, London, SE1 7EH, UK

Henry Völzke

130 Institut für Community Medicine, 17489 Greifswald, Germany

Hugh Watkins

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

121 Department of Cardiovascular Medicine, University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU

James F. Wilson

93 Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland

Leif C. Groop

91 Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden

Talin Haritunians

127 Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

Frank B. Hu

22 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA

23 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

45 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA

Robert C. Kaplan

193 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA

Andres Metspalu

38 Estonian Genome Center, University of Tartu, Tartu 50410, Estonia

39 Estonian Biocenter, Tartu 51010, Estonia

40 Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia

Kari E. North

55 Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514 USA

194 Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA

David Schlessinger

195 Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA

Nicholas J. Wareham

32 MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK

David J. Hunter

22 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA

23 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

45 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA

Jeffrey R. O'Connell

72 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA

David P. Strachan

196 Division of Community Health Sciences, St George's, University of London, London, SW17 0RE, UK

H.-Erich Wichmann

31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany

80 Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, 81377 Munich, Germany

197 Klinikum Grosshadern, 81377 Munich, Germany

Ingrid B. Borecki

37 Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA

175 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA

Cornelia M. van Duijn

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Eric E. Schadt

198 Pacific Biosciences, Menlo Park, California 94025, USA

199 Sage Bionetworks, Seattle, Washington 98109, USA

Unnur Thorsteinsdottir

20 deCODE Genetics, 101 Reykjavik, Iceland

200 Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland

Leena Peltonen

17 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

63 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland

64 National Institute for Health and Welfare, Department of Chronic Disease Prevention, Unit of Public Health Genomics, 00014, Helsinki, Finland

82 The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA

201 Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland

André Uitterlinden

2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands

3 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands

4 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)

Peter M. Visscher

19 Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland 4006, Australia

Nilanjan Chatterjee

7 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA

Ruth J.F. Loos

32 MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK

Michael Boehnke

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

Mark I. McCarthy

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

47 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK

202 NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK

Erik Ingelsson

60 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

Cecilia M. Lindgren

13 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

47 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK

Gonçalo R. Abecasis

8 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA

Kari Stefansson

20 deCODE Genetics, 101 Reykjavik, Iceland

200 Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland

Timothy M. Frayling

1 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX1 2LU, UK

Joel N Hirschhorn

9 Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA

10 Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA

203 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA