Side Effects of Minocycline: Different Dosage Regimens (original) (raw)

Antimicrob Agents Chemother. 1977 Nov; 12(5): 642–646.

Dieter W. Gump

1Department of Medicine, Division of Infectious Diseases, Burlington, Vermont 05401

Taka Ashikaga

2Department of Epidemiology and Environmental Health, University of Vermont College of Medicine, Burlington, Vermont 05401

Theodore J. Fink

1Department of Medicine, Division of Infectious Diseases, Burlington, Vermont 05401

Alan M. Radin

1Department of Medicine, Division of Infectious Diseases, Burlington, Vermont 05401

2Department of Epidemiology and Environmental Health, University of Vermont College of Medicine, Burlington, Vermont 05401

Abstract

The incidence of side effects due to two dosage regimens of minocycline was examined over a 5-day period. A total of 60 normal women volunteers were randomly assigned in a double-blind manner to either a group who took 100 mg of minocycline twice a day or a group who took 75 mg of minocycline twice a day for 5 days. Both groups were comparable from the standpoints of age, size, race, and the use of oral contraception, nicotine, and ethanol. They were seen on a daily basis, and symptoms were evaluated by both volunteers (from diaries) and physicians. Minocycline serum concentrations were determined on blood samples taken 2 h after the a.m. dose. Volunteers taking 150 mg of minocycline per day had significantly lower serum antibiotic concentrations than those taking 200 mg per day. However, both low- and high-dose groups exhibited similar incidence and prevalence of recorded symptoms, with the single exception of nausea, where the low-dose group had fewer symptoms than the high-dose group (P = 0.035). Symptomatic volunteers did not have higher serum concentrations of minocycline than their asymptomatic counterparts. When either weight or surface area was examined with antibiotic serum concentration there was a significant inverse correlation between the two on day 2 for both groups and also on day 4 for the low-dose group. It is concluded that, in women, a dose of 150 mg of minocycline per day is associated with the same degree of side effects as a dose of 200 mg per day.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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