Cerebrodiene: a brain lipid isolated from sleep-deprived cats. (original) (raw)

• Journal List
• Proc Natl Acad Sci U S A
• v.91(20); 1994 Sep 27
• PMC44841

Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20): 9505–9508.

Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.

Abstract

We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

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Selected References

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