The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life (original) (raw)

Abstract

OBJECTIVE--To determine how fetal growth is related to death from cardiovascular disease in adult life. DESIGN--A follow up study of men born during 1907-24 whose birth weights, head circumferences, and other body measurements were recorded at birth. SETTING--Sheffield, England. SUBJECTS--1586 Men born in the Jessop Hospital. MAIN OUTCOME MEASURE--Death from cardiovascular disease. RESULTS--Standardised mortality ratios for cardiovascular disease fell from 119 in men who weighed 5.5 pounds (2495 g) or less at birth to 74 in men who weighed more than 8.5 pounds (3856 g). The fall was significant for premature cardiovascular deaths up to 65 years of age (chi 2 = 5.0, p = 0.02). Standardised mortality ratios also fell with increasing head circumference (chi 2 = 4.6, p = 0.03) and increasing ponderal index (weight/length3) (chi 2 = 3.8, p = 0.05; for premature deaths chi 2 = 6.0, p = 0.01). They were not related to the duration of gestation. Among men for whom the ratio of placental weight to birth weight was in the highest fifths the standardised mortality ratio was 137. CONCLUSION--These findings show that reduced fetal growth is followed by increased mortality from cardiovascular disease. They suggest that reduction in growth begins early in gestation. They are further evidence that cardiovascular disease originates through programming of the body's structure, physiology, and metabolism by the environment during fetal life. Maternal nutrition may have an important influence on programming.

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Selected References

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  1. Barker D. J., Bull A. R., Osmond C., Simmonds S. J. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990 Aug 4;301(6746):259–262. doi: 10.1136/bmj.301.6746.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barker D. J., Godfrey K. M., Osmond C., Bull A. The relation of fetal length, ponderal index and head circumference to blood pressure and the risk of hypertension in adult life. Paediatr Perinat Epidemiol. 1992 Jan;6(1):35–44. doi: 10.1111/j.1365-3016.1992.tb00741.x. [DOI] [PubMed] [Google Scholar]
  3. Barker D. J., Hales C. N., Fall C. H., Osmond C., Phipps K., Clark P. M. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993 Jan;36(1):62–67. doi: 10.1007/BF00399095. [DOI] [PubMed] [Google Scholar]
  4. Barker D. J., Meade T. W., Fall C. H., Lee A., Osmond C., Phipps K., Stirling Y. Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ. 1992 Jan 18;304(6820):148–152. doi: 10.1136/bmj.304.6820.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barker D. J., Winter P. D., Osmond C., Margetts B., Simmonds S. J. Weight in infancy and death from ischaemic heart disease. Lancet. 1989 Sep 9;2(8663):577–580. doi: 10.1016/s0140-6736(89)90710-1. [DOI] [PubMed] [Google Scholar]
  6. Berry G. The analysis of mortality by the subject-years method. Biometrics. 1983 Mar;39(1):173–184. [PubMed] [Google Scholar]
  7. Blackwell B. N., Blackwell R. Q., Yu T. T., Weng Y. S., Chow B. F. Further studies on growth and feed utilization in progeny of underfed mother rats. J Nutr. 1969 Jan;97(1):79–84. doi: 10.1093/jn/97.1.79. [DOI] [PubMed] [Google Scholar]
  8. Dubos R., Savage D., Schaedler R. Biological Freudianism. Lasting effects of early environmental influences. Pediatrics. 1966 Nov;38(5):789–800. [PubMed] [Google Scholar]
  9. Faichney G. J., White G. A. Effects of maternal nutritional status on fetal and placental growth and on fetal urea synthesis in sheep. Aust J Biol Sci. 1987;40(4):365–377. doi: 10.1071/bi9870365. [DOI] [PubMed] [Google Scholar]
  10. Fall C. H., Barker D. J., Osmond C., Winter P. D., Clark P. M., Hales C. N. Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. BMJ. 1992 Mar 28;304(6830):801–805. doi: 10.1136/bmj.304.6830.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Godfrey K. M., Redman C. W., Barker D. J., Osmond C. The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br J Obstet Gynaecol. 1991 Sep;98(9):886–891. doi: 10.1111/j.1471-0528.1991.tb13510.x. [DOI] [PubMed] [Google Scholar]
  12. Hahn P. Effect of litter size on plasma cholesterol and insulin and some liver and adipose tissue enzymes in adult rodents. J Nutr. 1984 Jul;114(7):1231–1234. doi: 10.1093/jn/114.7.1231. [DOI] [PubMed] [Google Scholar]
  13. Hales C. N., Barker D. J., Clark P. M., Cox L. J., Fall C., Osmond C., Winter P. D. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991 Oct 26;303(6809):1019–1022. doi: 10.1136/bmj.303.6809.1019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Law C. M., Barker D. J., Bull A. R., Osmond C. Maternal and fetal influences on blood pressure. Arch Dis Child. 1991 Nov;66(11):1291–1295. doi: 10.1136/adc.66.11.1291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McCrabb G. J., Egan A. R., Hosking B. J. Maternal undernutrition during mid-pregnancy in sheep. Placental size and its relationship to calcium transfer during late pregnancy. Br J Nutr. 1991 Mar;65(2):157–168. doi: 10.1079/bjn19910077. [DOI] [PubMed] [Google Scholar]
  16. Robinson S. M., Wheeler T., Hayes M. C., Barker D. J., Osmond C. Fetal heart rate and intrauterine growth. Br J Obstet Gynaecol. 1991 Dec;98(12):1223–1227. doi: 10.1111/j.1471-0528.1991.tb15393.x. [DOI] [PubMed] [Google Scholar]
  17. Winick M., Noble A. Cellular response in rats during malnutrition at various ages. J Nutr. 1966 Jul;89(3):300–306. doi: 10.1093/jn/89.3.300. [DOI] [PubMed] [Google Scholar]