Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium (original) (raw)

. 1985 May;119(2):294–300.

Abstract

Previous studies utilizing enzyme histochemistry, electron microscopy, and immunohistochemistry have failed to establish the cell of origin in Kaposi's sarcoma. The authors have rigorously tested the prevailing hypothesis that the lesion defined as Kaposi's sarcoma is derived from vascular endothelial cells. They use seven markers to characterize endothelial cells: three antigens (Factor VIII-related antigen, HLA-DR/Ia, macrophage/endothelial antigens), three enzymes (5'-nucleotidase, ATPase, alkaline phosphatase), and lectin binding (Ulex europaeus I). They applied the markers first to normal skin and lymph node, and then to biopsy specimens from 40 patients with Kaposi's sarcoma. Normal blood vessel endothelium was positive for all seven markers, but normal lymphatic endothelium was negative for all of the markers except 5'-nucleotidase and Ulex europaeus lectin. The neoplastic cells in 40 cases of Kaposi's sarcoma closely resembled those of normal lymphatic endothelium but not those of blood vessel endothelium. This suggests that Kaposi's sarcoma may originate in lymphatic endothelium.

294

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akhtar M., Bunuan H., Ali M. A., Godwin J. T. Kaposi's sarcoma in renal transplant recipients. Ultrastructural and immunoperoxidase study of four cases. Cancer. 1984 Jan 15;53(2):258–266. doi: 10.1002/1097-0142(19840115)53:2<258::AID-CNCR2820530213>3.0.CO;2-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BECKER B. J. The histogenesis of Kaposi's sarcoma. Acta Unio Int Contra Cancrum. 1962;18:477–486. [PubMed] [Google Scholar]
  3. Beckstead J. H., Halverson P. S., Ries C. A., Bainton D. F. Enzyme histochemistry and immunohistochemistry on biopsy specimens of pathologic human bone marrow. Blood. 1981 Jun;57(6):1088–1098. [PubMed] [Google Scholar]
  4. Beckstead J. H. The evaluation of human lymph nodes, using plastic sections and enzyme histochemistry. Am J Clin Pathol. 1983 Aug;80(2):131–139. doi: 10.1093/ajcp/80.2.131. [DOI] [PubMed] [Google Scholar]
  5. Bloom A. L., Giddings J. C., Wilks C. J. Factor 8 on the vascular intima: possible importance in haemostasis and thrombosis. Nat New Biol. 1973 Feb 14;241(111):217–219. doi: 10.1038/newbio241217a0. [DOI] [PubMed] [Google Scholar]
  6. Braun-Falco O., Schmoeckel C., Hübner G. Zur Histogenese des Sarcoma idiopathicum multiplex haemorrhagicum (Morbus Kaposi): Eine histochemische und elektronenmikroskopische Studie. Virchows Arch A Pathol Anat Histol. 1976 Feb 16;369(3):215–227. doi: 10.1007/BF00427710. [DOI] [PubMed] [Google Scholar]
  7. Burgdorf W. H., Mukai K., Rosai J. Immunohistochemical identification of factor VIII-related antigen in endothelial cells of cutaneous lesions of alleged vascular nature. Am J Clin Pathol. 1981 Feb;75(2):167–171. doi: 10.1093/ajcp/75.2.167. [DOI] [PubMed] [Google Scholar]
  8. DORFMAN R. F. Kaposi's sarcoma. The contribution of enzyme histochemistry to the identification of cell types. Acta Unio Int Contra Cancrum. 1962;18:464–476. [PubMed] [Google Scholar]
  9. Flotte T. J., Hatcher V. A., Friedman-Kien A. E. Factor VIII-related antigen in Kaposi's sarcoma in young homosexual men. Arch Dermatol. 1984 Feb;120(2):180–182. [PubMed] [Google Scholar]
  10. Friedman-Kien A. E., Laubenstein L. J., Rubinstein P., Buimovici-Klein E., Marmor M., Stahl R., Spigland I., Kim K. S., Zolla-Pazner S. Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med. 1982 Jun;96(6 Pt 1):693–700. doi: 10.7326/0003-4819-96-6-693. [DOI] [PubMed] [Google Scholar]
  11. Gokel J. M., Kürzl R., Hübner G. Fine structure and origin of Kaposi's sarcoma. Pathol Eur. 1976;11(1):45–47. [PubMed] [Google Scholar]
  12. Guarda L. G., Silva E. G., Ordóez N. G., Smith J. L., Jr Factor VIII in Kaposi's sarcoma. Am J Clin Pathol. 1981 Aug;76(2):197–200. doi: 10.1093/ajcp/76.2.197. [DOI] [PubMed] [Google Scholar]
  13. HASHIMOTO K., LEVER W. F. KAPOSI'S SARCOMA. HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES. J Invest Dermatol. 1964 Dec;43:539–549. [PubMed] [Google Scholar]
  14. Harrison A. C., Kahn L. B. Myogenic cells in Kaposi's sarcoma: an ultrastructural study. J Pathol. 1978 Mar;124(3):157–160. doi: 10.1002/path.1711240305. [DOI] [PubMed] [Google Scholar]
  15. Hoyer L. W., De los Santos R. P., Hoyer J. R. Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy. J Clin Invest. 1973 Nov;52(11):2737–2744. doi: 10.1172/JCI107469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. KOPF A. W. The distribution of alkaline phosphatase in normal and pathologic human skin. AMA Arch Derm. 1957 Jan;75(1):1–37. doi: 10.1001/archderm.1957.01550130003001. [DOI] [PubMed] [Google Scholar]
  17. MUSTAKALLIO K. K., LEVONEN E., RAEKALLIO J. HISTOCHEMISTRY OF KAPOSI'S SARCOMA. I. HYDROLASES AND PHOSPHORYLASE. Exp Mol Pathol. 1963 Aug;40:303–316. doi: 10.1016/0014-4800(63)90012-1. [DOI] [PubMed] [Google Scholar]
  18. Mason D. Y., Biberfeld P. Technical aspects of lymphoma immunohistology. J Histochem Cytochem. 1980 Aug;28(8):731–745. doi: 10.1177/28.8.6160179. [DOI] [PubMed] [Google Scholar]
  19. McNutt N. S., Fletcher V., Conant M. A. Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin. Am J Pathol. 1983 Apr;111(1):62–77. [PMC free article] [PubMed] [Google Scholar]
  20. Miettinen M., Holthofer H., Lehto V. P., Miettinen A., Virtanen I. Ulex europaeus I lectin as a marker for tumors derived from endothelial cells. Am J Clin Pathol. 1983 Jan;79(1):32–36. doi: 10.1093/ajcp/79.1.32. [DOI] [PubMed] [Google Scholar]
  21. Modlin R. L., Hofman F. M., Kempf R. A., Taylor C. R., Conant M. A., Rea T. H. Kaposi's sarcoma in homosexual men: an immunohistochemical study. J Am Acad Dermatol. 1983 May;8(5):620–627. doi: 10.1016/s0190-9622(83)70067-8. [DOI] [PubMed] [Google Scholar]
  22. Mottaz J. H., Zelickson A. S. Electron microscope observations of Kaposi's sarcoma. Acta Derm Venereol. 1966;46(2):195–200. [PubMed] [Google Scholar]
  23. NIEMI M., MUSTAKALLIO K. K. THE FINE STRUCTURE OF THE SPINDLE CELL IN KAPOSI'S SARCOMA. Acta Pathol Microbiol Scand. 1965;63:567–575. doi: 10.1111/apm.1965.63.4.567. [DOI] [PubMed] [Google Scholar]
  24. NIEMI M., RAEKALLIO J., LEVONEN E., MUSTAKALLIO K. K. HISTOCHEMISTRY OF KAPOSI'S SARCOMA. II. CHOLINESTERASES, MONOAMINE OXIDASE, AND ADENOSINE TRIPHOSPHATASE. Exp Mol Pathol. 1964 Dec;90:648–657. doi: 10.1016/0014-4800(64)90040-1. [DOI] [PubMed] [Google Scholar]
  25. Nadji M., Morales A. R., Ziegles-Weissman J., Penneys N. S. Kaposi's sarcoma: immunohistologic evidence for an endothelial origin. Arch Pathol Lab Med. 1981 May;105(5):274–275. [PubMed] [Google Scholar]
  26. Ordóez N. G., Batsakis J. G. Comparison of Ulex europaeus I lectin and factor VIII-related antigen in vascular lesions. Arch Pathol Lab Med. 1984 Feb;108(2):129–132. [PubMed] [Google Scholar]
  27. PEPLER W. J. The origin of Kaposi's haemangiosarcoma: a histochemical study. J Pathol Bacteriol. 1959 Oct;78:553–557. doi: 10.1002/path.1700780222. [DOI] [PubMed] [Google Scholar]
  28. Sterry W., Steigleder G. K., Bodeux E. Kaposi's sarcoma: venous capillary haemangioblastoma. A histochemical and ultrastructural study. Arch Dermatol Res. 1979 Nov;266(3):253–267. doi: 10.1007/BF00418571. [DOI] [PubMed] [Google Scholar]
  29. TEDESCHI C. G. Some considerations concerning the nature of the so-called sarcoma of Kaposi. AMA Arch Pathol. 1958 Nov;66(5):656–684. [PubMed] [Google Scholar]
  30. Wilson A. J. Factor VIII-related antigen staining by immunoperoxidase technic in smaller laboratories: a potential problem. Am J Clin Pathol. 1984 Jan;81(1):117–120. doi: 10.1093/ajcp/81.1.117. [DOI] [PubMed] [Google Scholar]
  31. Wood G. S., Warnke R. Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. J Histochem Cytochem. 1981 Oct;29(10):1196–1204. doi: 10.1177/29.10.7028859. [DOI] [PubMed] [Google Scholar]