Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model (original) (raw)

• Journal List
• J Exp Med
• v.180(4); 1994 Oct 1
• PMC2191709

J Exp Med. 1994 Oct 1; 180(4): 1511–1516.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

Abstract

Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs.

Full Text

The Full Text of this article is available as a PDF (1.2M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

• Bittner JJ. SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE. Science. 1936 Aug 14;84(2172):162–162. [PubMed] [Google Scholar]
• Tsubura A, Inaba M, Imai S, Murakami A, Oyaizu N, Yasumizu R, Ohnishi Y, Tanaka H, Morii S, Ikehara S. Intervention of T-cells in transportation of mouse mammary tumor virus (milk factor) to mammary gland cells in vivo. Cancer Res. 1988 Nov 15;48(22):6555–6559. [PubMed] [Google Scholar]
• Acha-Orbea H, Held W, Waanders GA, Shakhov AN, Scarpellino L, Lees RK, MacDonald HR. Exogenous and endogenous mouse mammary tumor virus superantigens. Immunol Rev. 1993 Feb;131:5–25. [PubMed] [Google Scholar]
• Molina IJ, Cannon NA, Hyman R, Huber BT. Macrophages and T cells do not express Mlsa determinants. J Immunol. 1989 Jul 1;143(1):39–44. [PubMed] [Google Scholar]
• Held W, Shakhov AN, Izui S, Waanders GA, Scarpellino L, MacDonald HR, Acha-Orbea H. Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus. J Exp Med. 1993 Feb 1;177(2):359–366. [PMC free article] [PubMed] [Google Scholar]
• Held W, Waanders GA, Shakhov AN, Scarpellino L, Acha-Orbea H, MacDonald HR. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell. 1993 Aug 13;74(3):529–540. [PubMed] [Google Scholar]
• Choi Y, Kappler JW, Marrack P. A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus. Nature. 1991 Mar 21;350(6315):203–207. [PubMed] [Google Scholar]
• Logie AW, Logie DE. Brown MI, Frame A, Norris CA. Mitchell LIS. Fingland IW, Fingland MJ. Knox AM, Knox WA, Cameron CH. Anniversary of Hiroshima. Br Med J (Clin Res Ed) 1985 Aug 03;291(6491):d350–351. [PMC free article] [Google Scholar]
• Acha-Orbea H, Shakhov AN, Scarpellino L, Kolb E, Müller V, Vessaz-Shaw A, Fuchs R, Blöchlinger K, Rollini P, Billotte J, et al. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Nature. 1991 Mar 21;350(6315):207–211. [PubMed] [Google Scholar]
• Woodland DL, Happ MP, Gollob KJ, Palmer E. An endogenous retrovirus mediating deletion of alpha beta T cells? Nature. 1991 Feb 7;349(6309):529–530. [PubMed] [Google Scholar]
• Beutner U, Frankel WN, Cote MS, Coffin JM, Huber BT. Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5432–5436. [PMC free article] [PubMed] [Google Scholar]
• Pullen AM, Choi Y, Kushnir E, Kappler J, Marrack P. The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens. J Exp Med. 1992 Jan 1;175(1):41–47. [PMC free article] [PubMed] [Google Scholar]
• Golovkina TV, Chervonsky A, Dudley JP, Ross SR. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell. 1992 May 15;69(4):637–645. [PubMed] [Google Scholar]
• Held W, Shakhov AN, Waanders G, Scarpellino L, Luethy R, Kraehenbuhl JP, MacDonald HR, Acha-Orbea H. An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). J Exp Med. 1992 Jun 1;175(6):1623–1633. [PMC free article] [PubMed] [Google Scholar]
• Festenstein H, Berumen L. BALB.D2-Mlsa--a new congenic mouse strain. Transplantation. 1984 Mar;37(3):322–324. [PubMed] [Google Scholar]
• Payne J, Huber BT, Cannon NA, Schneider R, Schilham MW, Acha-Orbea H, MacDonald HR, Hengartner H. Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7695–7698. [PMC free article] [PubMed] [Google Scholar]
• Liao NS, Maltzman J, Raulet DH. Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. J Exp Med. 1989 Jul 1;170(1):135–143. [PMC free article] [PubMed] [Google Scholar]
• Hainaut P, Francois C, Calberg-Bacq CM, Vaira D, Osterrieth PM. Peroral infection of suckling mice with milk-borne mouse mammary tumour virus: uptake of the main viral antigens by the gut. J Gen Virol. 1983 Dec;64(Pt 12):2535–2548. [PubMed] [Google Scholar]
• Wolf JL, Rubin DH, Finberg R, Kauffman RS, Sharpe AH, Trier JS, Fields BN. Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981 Apr 24;212(4493):471–472. [PubMed] [Google Scholar]
• Kraehenbuhl JP, Neutra MR. Molecular and cellular basis of immune protection of mucosal surfaces. Physiol Rev. 1992 Oct;72(4):853–879. [PubMed] [Google Scholar]
• CLARK SL., Jr The ingestion of proteins and colloidal materials by columnar absorptive cells of the small intestine in suckling rats and mice. J Biophys Biochem Cytol. 1959 Jan 25;5(1):41–50. [PMC free article] [PubMed] [Google Scholar]
• Kraehenbuhl JP, Bron C, Sordat B. Transfer of humoral secretory and cellular immunity from mother to offspring. Curr Top Pathol. 1979;66:105–157. [PubMed] [Google Scholar]
• Keren DF. Antigen processing in the mucosal immune system. Semin Immunol. 1992 Aug;4(4):217–226. [PubMed] [Google Scholar]
• Bevilacqua G, Marchetti A, Biondi R. Ultrastructural features of the intestinal absorption of mouse mammary tumor virus in newborn BALB/cfRIII mice. Gastroenterology. 1989 Jan;96(1):139–145. [PubMed] [Google Scholar]
• Gonnella PA, Neutra MR. Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat ileum. J Cell Biol. 1984 Sep;99(3):909–917. [PMC free article] [PubMed] [Google Scholar]
• Waanders GA, Shakhov AN, Held W, Karapetian O, Acha-Orbea H, MacDonald HR. Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus. J Exp Med. 1993 May 1;177(5):1359–1366. [PMC free article] [PubMed] [Google Scholar]
• Marrack P, Kushnir E, Kappler J. A maternally inherited superantigen encoded by a mammary tumour virus. Nature. 1991 Feb 7;349(6309):524–526. [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press