Biochemical, cellular, and pharmacological aspects of the multidrug transporter - PubMed (original) (raw)
Review
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
S V Ambudkar et al. Annu Rev Pharmacol Toxicol. 1999.
Abstract
Considerable evidence has accumulated indicating that the multidrug transporter or P-glycoprotein plays a role in the development of simultaneous resistance to multiple cytotoxic drugs in cancer cells. In recent years, various approaches such as mutational analyses and biochemical and pharmacological characterization have yielded significant information about the relationship of structure and function of P-glycoprotein. However, there is still considerable controversy about the mechanism of action of this efflux pump and its function in normal cells. This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
Similar articles
- P-glycoprotein and membrane roles in multidrug resistance.
Ferreira RJ, dos Santos DJ, Ferreira MJ. Ferreira RJ, et al. Future Med Chem. 2015;7(7):929-46. doi: 10.4155/fmc.15.36. Future Med Chem. 2015. PMID: 26061109 Review. - Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.
Sharom FJ, Liu R, Qu Q, Romsicki Y. Sharom FJ, et al. Semin Cell Dev Biol. 2001 Jun;12(3):257-65. doi: 10.1006/scdb.2000.0251. Semin Cell Dev Biol. 2001. PMID: 11428918 Review. - Multidrug resistance: molecular and clinical aspects.
Dicato M, Duhem C, Pauly M, Ries F. Dicato M, et al. Cytokines Cell Mol Ther. 1997 Jun;3(2):91-9. Cytokines Cell Mol Ther. 1997. PMID: 9287248 Review. - Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P.
Wojtowicz K, Szaflarski W, Januchowski R, Zawierucha P, Nowicki M, Zabel M. Wojtowicz K, et al. Acta Biochim Pol. 2012;59(4):445-50. Epub 2012 Oct 23. Acta Biochim Pol. 2012. PMID: 23094261 Review. - Multidrug resistance in pediatric malignancies.
Chan HS, DeBoer G, Haddad G, Gallie BL, Ling V. Chan HS, et al. Hematol Oncol Clin North Am. 1995 Apr;9(2):275-318. Hematol Oncol Clin North Am. 1995. PMID: 7642465 Review.
Cited by
- Targeting ABCB1-mediated tumor multidrug resistance by CRISPR/Cas9-based genome editing.
Yang Y, Qiu JG, Li Y, Di JM, Zhang WJ, Jiang QW, Zheng DW, Chen Y, Wei MN, Huang JR, Wang K, Shi Z. Yang Y, et al. Am J Transl Res. 2016 Sep 15;8(9):3986-3994. eCollection 2016. Am J Transl Res. 2016. PMID: 27725879 Free PMC article. - CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3β/Snail Signals.
Lu LL, Chen XH, Zhang G, Liu ZC, Wu N, Wang H, Qi YF, Wang HS, Cai SH, Du J. Lu LL, et al. Oxid Med Cell Longev. 2016;2016:5874127. doi: 10.1155/2016/5874127. Epub 2015 Dec 28. Oxid Med Cell Longev. 2016. PMID: 27057280 Free PMC article. - Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma.
Koh I, Hinoi T, Sentani K, Hirata E, Nosaka S, Niitsu H, Miguchi M, Adachi T, Yasui W, Ohdan H, Kudo Y. Koh I, et al. Cancer Med. 2016 Jul;5(7):1546-55. doi: 10.1002/cam4.697. Epub 2016 Apr 6. Cancer Med. 2016. PMID: 27060927 Free PMC article. - Mechanistic Insights into Photodynamic Regulation of Adenosine 5'-Triphosphate-Binding Cassette Drug Transporters.
Liang BJ, Lusvarghi S, Ambudkar SV, Huang HC. Liang BJ, et al. ACS Pharmacol Transl Sci. 2021 Sep 15;4(5):1578-1587. doi: 10.1021/acsptsci.1c00138. eCollection 2021 Oct 8. ACS Pharmacol Transl Sci. 2021. PMID: 36118950 Free PMC article. - Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.
Wink M, Ashour ML, El-Readi MZ. Wink M, et al. Front Microbiol. 2012 Apr 23;3:130. doi: 10.3389/fmicb.2012.00130. eCollection 2012. Front Microbiol. 2012. PMID: 22536197 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources