High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia - PubMed (original) (raw)

Comparative Study

. 1999 Jul 15;94(2):754-64.

Affiliations

• PMID: 10397743

Free article

Comparative Study

High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia

T B Geijtenbeek et al. Blood. 1999.

Free article

Abstract

Aberrant proliferation, differentiation, and/or migration of progenitors observed in various hematological malignancies may be caused by defects in expression and/or function of integrins. In this study, we have developed a new fluorescent beads adhesion assay that facilitates flow cytometric investigation of lymphocyte function-associated antigen 1 (LFA-1)- and very late activation antigen-4 (VLA-4)-mediated functional adhesion in B-lineage acute lymphoblastic leukemia (ALL) of both the CD10(-) and CD10(+) (leukemic) cell population within one blood or bone marrow sample. Surprisingly, of the 20 B-lineage ALL patients investigated, 17 contained a leukemic cell population with LFA-1- and/or VLA-4-mediated adhesion defects. Five patients contained CD10(+) cells that did not exhibit any LFA-1-mediated adhesion due to the lack of LFA-1 surface expression. The CD10(+) cells from 10 ALL patients expressed LFA-1 that could not be activated by the phorbol ester phorbol 12-myristate 13-acetate (PMA), whereas the CD10(-) cells expressed a functional LFA-1. Seven patients contained CD10(+) cells that expressed a PMA-unresponsive form of VLA-4. The PMA unresponsiveness of the integrins LFA-1 and VLA-4 expressed by the CD10(+) cells may be due to mutations in the integrins itself, in protein kinases, or in other intracellular molecules involved in integrin adhesion. These data clearly demonstrate the importance of investigating integrin function in addition to integrin surface expression. The strikingly high frequency (85%) of adhesion defects in ALL could suggest a causal relationship between integrin-mediated adhesion and B-lineage ALL.

PubMed Disclaimer

Similar articles

• CD10/common acute lymphoblastic leukemia-associated antigen and adhesion factor expression is predictive for lymphokine-activated killing sensitivity of adult B-lineage acute lymphoblastic leukemia.
  Correale P, Tagliaferri P, Camera A, Caraglia M, Del Vecchio L, De Laurentis M, Pinto A, Rotoli B, Bianco AR. Correale P, et al. Year Immunol. 1993;7:90-5. Year Immunol. 1993. PMID: 7690510 No abstract available.
• The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
  de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL. de Bruyn KM, et al. J Biol Chem. 2002 Aug 16;277(33):29468-76. doi: 10.1074/jbc.M204990200. Epub 2002 May 24. J Biol Chem. 2002. PMID: 12171996
• Beta-1-integrin expression in adult acute lymphoblastic leukemia: possible relationship with the stem cell antigen CD34.
  Cacciola RR, Stagno F, Impera S, Assisi AR, Cacciola E Jr, Guglielmo P. Cacciola RR, et al. Acta Haematol. 1997;97(1-2):63-6. doi: 10.1159/000203660. Acta Haematol. 1997. PMID: 8980611 Review.
• Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases.
  Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ. Yusuf-Makagiansar H, et al. Med Res Rev. 2002 Mar;22(2):146-67. doi: 10.1002/med.10001. Med Res Rev. 2002. PMID: 11857637 Review.

Cited by

• Constitutive integrin activation on tumor cells contributes to progression of leptomeningeal metastases.
  Brandsma D, Ulfman L, Reijneveld JC, Bracke M, Taphoorn MJ, Zwaginga JJ, Gebbink MF, de Boer H, Koenderman L, Voest EE. Brandsma D, et al. Neuro Oncol. 2006 Apr;8(2):127-36. doi: 10.1215/15228517-2005-013. Epub 2006 Mar 13. Neuro Oncol. 2006. PMID: 16533879 Free PMC article.
• Novel member of the CD209 (DC-SIGN) gene family in primates.
  Bashirova AA, Wu L, Cheng J, Martin TD, Martin MP, Benveniste RE, Lifson JD, KewalRamani VN, Hughes A, Carrington M. Bashirova AA, et al. J Virol. 2003 Jan;77(1):217-27. doi: 10.1128/jvi.77.1.217-227.2003. J Virol. 2003. PMID: 12477827 Free PMC article.
• Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton.
  Nelissen JM, Peters IM, de Grooth BG, van Kooyk Y, Figdor CG. Nelissen JM, et al. Mol Biol Cell. 2000 Jun;11(6):2057-68. doi: 10.1091/mbc.11.6.2057. Mol Biol Cell. 2000. PMID: 10848629 Free PMC article.
• The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
  Saeland E, van Vliet SJ, Bäckström M, van den Berg VC, Geijtenbeek TB, Meijer GA, van Kooyk Y. Saeland E, et al. Cancer Immunol Immunother. 2007 Aug;56(8):1225-36. doi: 10.1007/s00262-006-0274-z. Epub 2006 Dec 29. Cancer Immunol Immunother. 2007. PMID: 17195076 Free PMC article.
• Human Milk Oligosaccharide 2'-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin.
  Mukherjee R, Somovilla VJ, Chiodo F, Bruijns S, Pieters RJ, Garssen J, van Kooyk Y, Kraneveld AD, van Bergenhenegouwen J. Mukherjee R, et al. Int J Mol Sci. 2022 Nov 25;23(23):14745. doi: 10.3390/ijms232314745. Int J Mol Sci. 2022. PMID: 36499067 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database