DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells - PubMed (original) (raw)

. 2000 Mar 3;100(5):587-97.

doi: 10.1016/s0092-8674(00)80694-7.

D S Kwon, R Torensma, S J van Vliet, G C van Duijnhoven, J Middel, I L Cornelissen, H S Nottet, V N KewalRamani, D R Littman, C G Figdor, Y van Kooyk

Affiliations

• PMID: 10721995
• DOI: 10.1016/s0092-8674(00)80694-7

Free article

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

T B Geijtenbeek et al. Cell. 2000.

Free article

Abstract

Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.

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Comment in

• DC-SIGN: a guide to some mysteries of dendritic cells.
  Steinman RM. Steinman RM. Cell. 2000 Mar 3;100(5):491-4. doi: 10.1016/s0092-8674(00)80684-4. Cell. 2000. PMID: 10721985 Review. No abstract available.

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