Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 - PubMed (original) (raw)
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
L Steidler et al. Science. 2000.
Abstract
The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of inflammatory bowel disease (IBD). Using two mouse models, we show that the therapeutic dose of IL-10 can be reduced by localized delivery of a bacterium genetically engineered to secrete the cytokine. Intragastric administration of IL-10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10(-/-) mice. This approach may lead to better methods for cost-effective and long-term management of IBD in humans.
Comment in
- Immunology. Therapeutic manipulation of gut flora.
Shanahan F. Shanahan F. Science. 2000 Aug 25;289(5483):1311-2. doi: 10.1126/science.289.5483.1311. Science. 2000. PMID: 10979858
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