A novel aldose/aldehyde reductase protects transgenic plants against lipid peroxidation under chemical and drought stresses - PubMed (original) (raw)
A novel aldose/aldehyde reductase protects transgenic plants against lipid peroxidation under chemical and drought stresses
A Oberschall et al. Plant J. 2000 Nov.
Free article
Abstract
Rapid accumulation of toxic products from reactions of reactive oxygen species (ROS) with lipids and proteins significantly contributes to the damage of crop plants under biotic and abiotic stresses. Here we have identified a stress-activated alfalfa gene encoding a novel plant NADPH-dependent aldose/aldehyde reductase that also exhibited characteristics of the homologous human enzyme. The recombinant alfalfa enzyme is active on 4-hydroxynon-2-enal, a known cytotoxic lipid peroxide degradation product. Ectopic synthesis of this enzyme in transgenic tobacco plants provided considerable tolerance against oxidative damage caused by paraquat and heavy metal treatment. These transformants could also resist a long period of water deficiency and exhibited improved recovery after rehydration. We found a reduced production of lipid peroxidation-derived reactive aldehydes in these transformed plants under different stresses. These studies reveal a new and efficient detoxification pathway in plants.
Similar articles
- Targeting detoxification pathways: an efficient approach to obtain plants with multiple stress tolerance?
Bartels D. Bartels D. Trends Plant Sci. 2001 Jul;6(7):284-6. doi: 10.1016/s1360-1385(01)01983-5. Trends Plant Sci. 2001. PMID: 11435150 - Stress tolerance of transgenic barley accumulating the alfalfa aldose reductase in the cytoplasm and the chloroplast.
Nagy B, Majer P, Mihály R, Pauk J, Horváth GV. Nagy B, et al. Phytochemistry. 2016 Sep;129:14-23. doi: 10.1016/j.phytochem.2016.07.007. Epub 2016 Jul 25. Phytochemistry. 2016. PMID: 27469099 - Xerophyta viscosa Aldose Reductase, XvAld1, Enhances Drought Tolerance in Transgenic Sweetpotato.
Mbinda W, Ombori O, Dixelius C, Oduor R. Mbinda W, et al. Mol Biotechnol. 2018 Mar;60(3):203-214. doi: 10.1007/s12033-018-0063-x. Mol Biotechnol. 2018. PMID: 29423655 - Heavy-metal-induced reactive oxygen species: phytotoxicity and physicochemical changes in plants.
Shahid M, Pourrut B, Dumat C, Nadeem M, Aslam M, Pinelli E. Shahid M, et al. Rev Environ Contam Toxicol. 2014;232:1-44. doi: 10.1007/978-3-319-06746-9_1. Rev Environ Contam Toxicol. 2014. PMID: 24984833 Review. - Lipid-Derived Aldehydes: New Key Mediators of Plant Growth and Stress Responses.
Liang X, Qian R, Wang D, Liu L, Sun C, Lin X. Liang X, et al. Biology (Basel). 2022 Oct 29;11(11):1590. doi: 10.3390/biology11111590. Biology (Basel). 2022. PMID: 36358291 Free PMC article. Review.
Cited by
- Identification of heavy metal-induced genes encoding glutathione S-transferases in the arbuscular mycorrhizal fungus Glomus intraradices.
Waschke A, Sieh D, Tamasloukht M, Fischer K, Mann P, Franken P. Waschke A, et al. Mycorrhiza. 2006 Dec;17(1):1-10. doi: 10.1007/s00572-006-0075-4. Epub 2006 Oct 24. Mycorrhiza. 2006. PMID: 17061124 - Lipid Peroxide-Derived Short-Chain Carbonyls Mediate Hydrogen Peroxide-Induced and Salt-Induced Programmed Cell Death in Plants.
Biswas MS, Mano J. Biswas MS, et al. Plant Physiol. 2015 Jul;168(3):885-98. doi: 10.1104/pp.115.256834. Epub 2015 May 29. Plant Physiol. 2015. PMID: 26025050 Free PMC article. - Genome-Wide Identification and Expression Analysis of the Protease Inhibitor Gene Families in Tomato.
Fan Y, Yang W, Yan Q, Chen C, Li J. Fan Y, et al. Genes (Basel). 2019 Dec 18;11(1):1. doi: 10.3390/genes11010001. Genes (Basel). 2019. PMID: 31861342 Free PMC article. - Comparative proteomics of skeletal muscle mitochondria from myostatin-null mice.
Puddick J, Martinus RD. Puddick J, et al. Cell Biol Int Rep (2010). 2011 Nov 30;18(2):e00013. doi: 10.1042/CBR20110006. Cell Biol Int Rep (2010). 2011. PMID: 23124711 Free PMC article. - The Xerophyta viscosa aldose reductase (ALDRXV4) confers enhanced drought and salinity tolerance to transgenic tobacco plants by scavenging methylglyoxal and reducing the membrane damage.
Kumar D, Singh P, Yusuf MA, Upadhyaya CP, Roy SD, Hohn T, Sarin NB. Kumar D, et al. Mol Biotechnol. 2013 Jun;54(2):292-303. doi: 10.1007/s12033-012-9567-y. Mol Biotechnol. 2013. PMID: 22678928
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources