Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study - PubMed (original) (raw)
Multicenter Study
Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study
S Illi et al. BMJ. 2001.
Abstract
Objective: To investigate the association between early childhood infections and subsequent development of asthma.
Design: Longitudinal birth cohort study.
Setting: Five children's hospitals in five German cities.
Participants: 1314 children born in 1990 followed from birth to the age of 7 years.
Main outcome measures: Asthma and asthmatic symptoms assessed longitudinally by parental questionnaires; atopic sensitisation assessed longitudinally by determination of IgE concentrations to various allergens; bronchial hyperreactivity assessed by bronchial histamine challenge at age 7 years.
Results: Compared with children with </=1 episode of runny nose before the age of 1 year, those with >/=2 episodes were less likely to have a doctor's diagnosis of asthma at 7 years old (odds ratio 0.52 (95% confidence interval 0.29 to 0.92)) or to have wheeze at 7 years old (0.60 (0.38 to 0.94)), and were less likely to be atopic before the age of 5 years. Similarly, having >/=1 viral infection of the herpes type in the first 3 years of life was inversely associated with asthma at age 7 (odds ratio 0.48 (0.26 to 0.89)). Repeated lower respiratory tract infections in the first 3 years of life showed a positive association with wheeze up to the age of 7 years (odds ratio 3.37 (1.92 to 5.92) for >/=4 infections v </=3 infections).
Conclusion: Repeated viral infections other than lower respiratory tract infections early in life may reduce the risk of developing asthma up to school age.
Figures
Figure
Longitudinal analysis of repeated episodes (⩾2) of runny nose in the first year of life and 12 month prevalences of wheeze up to the age of 7 years. Values are odds ratios with 95% confidence intervals adjusted for parental education, high risk of atopy at birth, parental smoking at birth, and age
Comment in
- The protective effect of childhood infections.
Johnston SL, Openshaw PJ. Johnston SL, et al. BMJ. 2001 Feb 17;322(7283):376-7. doi: 10.1136/bmj.322.7283.376. BMJ. 2001. PMID: 11179141 Free PMC article. No abstract available. - Asthma and early childhood infectious disease. Infection is trigger rather than cause.
Angelakou V, Bitsori M, Galanakis E. Angelakou V, et al. BMJ. 2001 Jul 21;323(7305):164. BMJ. 2001. PMID: 11463693 Free PMC article. No abstract available.
Similar articles
- The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS).
Lau S, Nickel R, Niggemann B, Grüber C, Sommerfeld C, Illi S, Kulig M, Forster J, Wahn U, Groeger M, Zepp F, Kamin W, Bieber I, Tacke U, Wahn V, Bauer CP, Bergmann R, von Mutius E; MAS Group. Lau S, et al. Paediatr Respir Rev. 2002 Sep;3(3):265-72. doi: 10.1016/s1526-0542(02)00189-6. Paediatr Respir Rev. 2002. PMID: 12376064 Review. - Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age.
Arshad SH, Kurukulaaratchy RJ, Fenn M, Matthews S. Arshad SH, et al. Chest. 2005 Feb;127(2):502-8. doi: 10.1378/chest.127.2.502. Chest. 2005. PMID: 15705988 - Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children.
von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. von Mutius E, et al. Eur Respir J. 1999 Jul;14(1):4-11. doi: 10.1034/j.1399-3003.1999.14a03.x. Eur Respir J. 1999. PMID: 10489821 Clinical Trial. - Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90).
Lau S, Illi S, Platts-Mills TA, Riposo D, Nickel R, Grüber C, Niggemann B, Wahn U; Multicentre Allergy Study Group. Lau S, et al. Allergy. 2005 Jun;60(6):766-73. doi: 10.1111/j.1398-9995.2005.00781.x. Allergy. 2005. PMID: 15876306 - The relationship of viral respiratory infections and asthma.
Busse WW, Lemanske RF Jr, Dick EC. Busse WW, et al. Chest. 1992 Jun;101(6 Suppl):385S-388S. doi: 10.1378/chest.101.6_supplement.385s. Chest. 1992. PMID: 1591936 Review. No abstract available.
Cited by
- Living at high altitude and risk of hospitalisation for atopic asthma in children: results from a large prospective birth-cohort study.
Kiechl-Kohlendorfer U, Horak E, Mueller W, Strobl R, Haberland C, Fink FM, Schwaiger M, Gutenberger KH, Reich H, Meraner D, Kiechl S. Kiechl-Kohlendorfer U, et al. Arch Dis Child. 2007 Apr;92(4):339-42. doi: 10.1136/adc.2006.106278. Arch Dis Child. 2007. PMID: 17376940 Free PMC article. - Prevalence, Management, and Risk Factors of Asthma Among School-Age Children in Yogyakarta, Indonesia.
Triasih R, Setyowireni D, Nurani N, Setyati A. Triasih R, et al. J Asthma Allergy. 2023 Jan 5;16:23-32. doi: 10.2147/JAA.S392733. eCollection 2023. J Asthma Allergy. 2023. PMID: 36636706 Free PMC article. - Childhood Morbidity and Health in Early Adulthood: Life course linkages in a high morbidity context.
Margolis R. Margolis R. Adv Life Course Res. 2010 Dec 1;15(4):132-146. doi: 10.1016/j.alcr.2010.10.001. Adv Life Course Res. 2010. PMID: 21516232 Free PMC article. - Epidemiology and Immunopathogenesis of Virus Associated Asthma Exacerbations.
Bakakos A, Sotiropoulou Z, Vontetsianos A, Zaneli S, Papaioannou AI, Bakakos P. Bakakos A, et al. J Asthma Allergy. 2023 Sep 26;16:1025-1040. doi: 10.2147/JAA.S277455. eCollection 2023. J Asthma Allergy. 2023. PMID: 37791040 Free PMC article. Review. - The costimulatory role of TIM molecules.
Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, Umetsu DT. Rodriguez-Manzanet R, et al. Immunol Rev. 2009 May;229(1):259-70. doi: 10.1111/j.1600-065X.2009.00772.x. Immunol Rev. 2009. PMID: 19426227 Free PMC article. Review.
References
- Jarvis D, Chinn S, Luczynska C, Burney P. The association of family size with atopy and atopic disease. Clin Exp Allergy. 1997;27:240–245. - PubMed
- Krämer U, Heinrich J, Wijst M, Wichmann HE. Age of entry to day nursery and allergy in later childhood. Lancet. 1998;352:450–454. - PubMed