Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort - PubMed (original) (raw)
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
P F Jacques et al. Am J Clin Nutr. 2001 Mar.
Abstract
Background: Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function.
Objective: Our objective was to examine the relation between known and suspected determinants of fasting plasma tHcy in a population-based cohort.
Design: We examined the relations between fasting plasma tHcy concentrations and nutritional and other health factors in 1960 men and women, aged 28-82 y, from the fifth examination cycle of the Framingham Offspring Study between 1991 and 1994, before the implementation of folic acid fortification.
Results: Geometric mean tHcy was 11% higher in men than in women and 23% higher in persons aged > or = 65 y than in persons aged < 45 y (P < 0.001). tHcy was associated with plasma folate, vitamin B-12, and pyridoxal phosphate (P for trend < 0.001). Dietary folate, vitamin B-6, and riboflavin were associated with tHcy among non-supplement users (P for trend < 0.01). The tHcy concentrations of persons who used vitamin B supplements were 18% lower than those of persons who did not (P < 0.001). tHcy was positively associated with alcohol intake (P for trend = 0.004), caffeine intake (P for trend < 0.001), serum creatinine (P for trend < 0.001), number of cigarettes smoked (P for trend < 0.001), and antihypertensive medication use (P < 0.001).
Conclusions: Our study confirmed, in a population-based setting, the importance of the known determinants of fasting tHcy and suggested that other dietary and lifestyle factors, including vitamin B-6, riboflavin, alcohol, and caffeine intakes as well as smoking and hypertension, influence circulating tHcy concentrations.
Comment in
- Population determinants of homocysteine.
Vollset SE, Refsum H, Ueland PM. Vollset SE, et al. Am J Clin Nutr. 2001 Mar;73(3):499-500. doi: 10.1093/ajcn/73.3.499. Am J Clin Nutr. 2001. PMID: 11237921 No abstract available. - Effect of obesity on plasma homocysteine.
Astrup A. Astrup A. Am J Clin Nutr. 2001 Oct;74(4):558-9. doi: 10.1093/ajcn/74.4.558. Am J Clin Nutr. 2001. PMID: 11566663 No abstract available. - Moderate alcohol consumption and the risk of cardiovascular disease.
Bleich S, Bleich K. Bleich S, et al. Am J Clin Nutr. 2002 May;75(5):948. doi: 10.1093/ajcn/75.5.948. Am J Clin Nutr. 2002. PMID: 11976173 No abstract available.
Similar articles
- Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.
McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM. McKinley MC, et al. Am J Clin Nutr. 2001 Apr;73(4):759-64. doi: 10.1093/ajcn/73.4.759. Am J Clin Nutr. 2001. PMID: 11273851 Clinical Trial. - Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use.
Koehler KM, Baumgartner RN, Garry PJ, Allen RH, Stabler SP, Rimm EB. Koehler KM, et al. Am J Clin Nutr. 2001 Mar;73(3):628-37. doi: 10.1093/ajcn/73.3.628. Am J Clin Nutr. 2001. PMID: 11237942 - Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors.
Strassburg A, Krems C, Lührmann PM, Hartmann B, Neuhäuser-Berthold M. Strassburg A, et al. Int J Vitam Nutr Res. 2004 Mar;74(2):129-36. doi: 10.1024/0300-9831.74.2.129. Int J Vitam Nutr Res. 2004. PMID: 15255449 - Plasma total homocysteine status of vegetarians compared with omnivores: a systematic review and meta-analysis.
Obersby D, Chappell DC, Dunnett A, Tsiami AA. Obersby D, et al. Br J Nutr. 2013 Mar 14;109(5):785-94. doi: 10.1017/S000711451200520X. Epub 2013 Jan 8. Br J Nutr. 2013. PMID: 23298782 Review. - The many facets of hyperhomocysteinemia: studies from the Framingham cohorts.
Selhub J. Selhub J. J Nutr. 2006 Jun;136(6 Suppl):1726S-1730S. doi: 10.1093/jn/136.6.1726S. J Nutr. 2006. PMID: 16702347 Review.
Cited by
- Animal and plant protein intake association with mental health, tryptophan metabolites pathways, and gut microbiota in healthy women: a cross-sectional study.
Soveid N, Barkhidarian B, Samadi M, Hatami M, Gholami F, Yekaninejad MS, Saedisomeolia A, Karbasian M, Siadat SD, Mirzaei K. Soveid N, et al. BMC Microbiol. 2024 Oct 7;24(1):390. doi: 10.1186/s12866-024-03534-8. BMC Microbiol. 2024. PMID: 39375584 Free PMC article. - Current Evidence and Future Perspectives of the Best Supplements for Cardioprotection: Have We Reached the Final Chapter for Vitamins?
Yasmin F, Ali SH, Naeem A, Savul S, Afridi MSI, Kamran N, Fazal F, Khawer S, Savul IS, Najeeb H, Asim HS, Nausherwan M, Asghar MS. Yasmin F, et al. Rev Cardiovasc Med. 2022 Nov 9;23(11):381. doi: 10.31083/j.rcm2311381. eCollection 2022 Nov. Rev Cardiovasc Med. 2022. PMID: 39076184 Free PMC article. Review. - Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women.
Tajima A, Kubo Y, Horiguchi S, Shoji K, Kawabata T. Tajima A, et al. Nutrients. 2023 Nov 10;15(22):4740. doi: 10.3390/nu15224740. Nutrients. 2023. PMID: 38004134 Free PMC article. - Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden.
Hesselink A, Winkvist A, Lindahl B, Ueland PM, Schneede J, Johansson I, Karlsson T. Hesselink A, et al. Nutr J. 2023 May 17;22(1):26. doi: 10.1186/s12937-023-00853-w. Nutr J. 2023. PMID: 37198607 Free PMC article. - Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study.
Rouhani P, Amoushahi M, Keshteli AH, Saneei P, Afshar H, Esmaillzadeh A, Adibi P. Rouhani P, et al. Sci Rep. 2023 Mar 29;13(1):5152. doi: 10.1038/s41598-023-32309-w. Sci Rep. 2023. PMID: 36991113 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical