Clinical staging of chronic lymphocytic leukemia - PubMed (original) (raw)
- PMID: 1139039
Free article
Clinical staging of chronic lymphocytic leukemia
K R Rai et al. Blood. 1975 Aug.
Free article
Abstract
A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. Analysis of 125 patients. in the present series showed the following median survival times (in months) from diagnosis: stage 0, is greater than 150; stage I 101; stage II, 71; stage III, 19; stage IV, 19, The median survival for the entire series was 71 mo. The prognostic significance of the stage remained even after adjustment was made for age and sex. However, both sex and age were shown to be poor predictors of survival after adjustment for stage. The method of staging proved to be a reliable predictor of survival whether used at diagnosis or during the course of the disease. The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients
Similar articles
- Chronic lymphocytic leukaemia: a test of a proposed new clinical staging system.
Geisler C, Hansen MM. Geisler C, et al. Scand J Haematol. 1981 Oct;27(4):279-86. doi: 10.1111/j.1600-0609.1981.tb00485.x. Scand J Haematol. 1981. PMID: 7346994 - Chronic lymphocytic leukaemia: proposals for a revised prognostic staging system. Report from the International Workshop on CLL.
[No authors listed] [No authors listed] Br J Haematol. 1981 Jul;48(3):365-7. doi: 10.1111/j.1365-2141.1981.tb02727.x. Br J Haematol. 1981. PMID: 7259986 No abstract available. - Multivariate analysis of prognostic factors in chronic lymphocytic leukemia.
Prokocimer M, Modan M, Lusky A, Hershko C. Prokocimer M, et al. Isr J Med Sci. 1985 Jun;21(6):490-8. Isr J Med Sci. 1985. PMID: 4019142 - Prognostic factors in chronic lymphocytic leukaemia and their implications for therapy.
Phillips EA, Kempin S, Passe S, Miké V, Clarkson B. Phillips EA, et al. Clin Haematol. 1977 Feb;6(1):203-22. Clin Haematol. 1977. PMID: 334410 Review. No abstract available. - Cell kinetics in chronic lymphocytic leukaemia (CLL).
Stryckmans PA, Debusscher L, Collard E. Stryckmans PA, et al. Clin Haematol. 1977 Feb;6(1):159-67. Clin Haematol. 1977. PMID: 334407 Review.
Cited by
- Cluster of Differentiation Markers and Human Leukocyte Antigen Expression in Chronic Lymphocytic Leukemia Patients: Correlations and Clinical Relevance.
Tizu M, Calenic B, Constantinescu AE, Bratei AA, Stoia RA, Popa MC, Constantinescu I. Tizu M, et al. Curr Issues Mol Biol. 2024 Sep 11;46(9):10008-10025. doi: 10.3390/cimb46090598. Curr Issues Mol Biol. 2024. PMID: 39329950 Free PMC article. - Chronic Lymphocytic Leukemia: Prognostic Factors in the Era of Novel Drugs.
Urso A, Martino EA, Cuneo A, Gentile M, Rigolin GM. Urso A, et al. Cancers (Basel). 2024 Jul 31;16(15):2732. doi: 10.3390/cancers16152732. Cancers (Basel). 2024. PMID: 39123460 Free PMC article. Review. - An overview of prognostic markers in patients with CLL.
Braish J, Cerchione C, Ferrajoli A. Braish J, et al. Front Oncol. 2024 May 16;14:1371057. doi: 10.3389/fonc.2024.1371057. eCollection 2024. Front Oncol. 2024. PMID: 38817892 Free PMC article. Review. - Potential New Therapies "ROS-Based" in CLL: An Innovative Paradigm in the Induction of Tumor Cell Apoptosis.
Sciaccotta R, Gangemi S, Penna G, Giordano L, Pioggia G, Allegra A. Sciaccotta R, et al. Antioxidants (Basel). 2024 Apr 17;13(4):475. doi: 10.3390/antiox13040475. Antioxidants (Basel). 2024. PMID: 38671922 Free PMC article. Review. - The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.
Al-Adl M, Youssef MM, El-Sebaie A, Refaat S, El-Said A. Al-Adl M, et al. Oncol Res. 2024 Mar 20;32(4):785-797. doi: 10.32604/or.2024.047021. eCollection 2024. Oncol Res. 2024. PMID: 38560574 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources