Immune recognition. A new receptor for beta-glucans - PubMed (original) (raw)
. 2001 Sep 6;413(6851):36-7.
doi: 10.1038/35092620.
Affiliations
- PMID: 11544516
- DOI: 10.1038/35092620
Immune recognition. A new receptor for beta-glucans
G D Brown et al. Nature. 2001.
Abstract
The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans.
Similar articles
- beta-Glucans and dectin-1.
Tsoni SV, Brown GD. Tsoni SV, et al. Ann N Y Acad Sci. 2008 Nov;1143:45-60. doi: 10.1196/annals.1443.019. Ann N Y Acad Sci. 2008. PMID: 19076344 Review. - The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.
Willment JA, Marshall AS, Reid DM, Williams DL, Wong SY, Gordon S, Brown GD. Willment JA, et al. Eur J Immunol. 2005 May;35(5):1539-47. doi: 10.1002/eji.200425725. Eur J Immunol. 2005. PMID: 15816015 - Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.
Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, Power TD, Wempe MF, Williams DL. Adams EL, et al. J Pharmacol Exp Ther. 2008 Apr;325(1):115-23. doi: 10.1124/jpet.107.133124. Epub 2008 Jan 2. J Pharmacol Exp Ther. 2008. PMID: 18171906 - Contribution of dectin-1 and granulocyte macrophage-colony stimulating factor (GM-CSF) to immunomodulating actions of beta-glucan.
Harada T, Ohno N. Harada T, et al. Int Immunopharmacol. 2008 Apr;8(4):556-66. doi: 10.1016/j.intimp.2007.12.011. Epub 2008 Jan 16. Int Immunopharmacol. 2008. PMID: 18328447 Review.
Cited by
- Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration.
Hargarten JC, Moore TC, Petro TM, Nickerson KW, Atkin AL. Hargarten JC, et al. Infect Immun. 2015 Oct;83(10):3857-64. doi: 10.1128/IAI.00886-15. Epub 2015 Jul 20. Infect Immun. 2015. PMID: 26195556 Free PMC article. - PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow.
Yu Y, Wang RR, Miao NJ, Tang JJ, Zhang YW, Lu XR, Yan PY, Wang J, Jia XM. Yu Y, et al. Nat Commun. 2022 Nov 11;13(1):6857. doi: 10.1038/s41467-022-34722-7. Nat Commun. 2022. PMID: 36369287 Free PMC article. - Effect of torula yeast on growth performance, diarrhea incidence, and blood characteristics in weanling pigs.
Espinosa CD, Lagos LV, Stein HH. Espinosa CD, et al. J Anim Sci. 2020 Oct 1;98(10):skaa307. doi: 10.1093/jas/skaa307. J Anim Sci. 2020. PMID: 32918083 Free PMC article. - C-type lectins in immunity: recent developments.
Dambuza IM, Brown GD. Dambuza IM, et al. Curr Opin Immunol. 2015 Feb;32:21-7. doi: 10.1016/j.coi.2014.12.002. Epub 2014 Dec 29. Curr Opin Immunol. 2015. PMID: 25553393 Free PMC article. Review. - An Adenoviral Vector Encoding Full-Length Dectin-1 Promotes Aspergillus-Induced Innate Immune Response in Macrophages.
Xia D, Sun WK, Tan MM, Ding Y, Liu ZC, Li P, Qian Q, Su X, Shi Y. Xia D, et al. Lung. 2015 Aug;193(4):549-57. doi: 10.1007/s00408-015-9740-8. Epub 2015 May 6. Lung. 2015. PMID: 25944256
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases