How nucleotide excision repair protects against cancer - PubMed (original) (raw)

Review

How nucleotide excision repair protects against cancer

E C Friedberg. Nat Rev Cancer. 2001 Oct.

Abstract

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type--nucleotide excision repair (NER)--specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

PubMed Disclaimer

Similar articles

• [Repair of DNA damage using nucleotide excision repair (NER)--relationship with cancer risk].
  Butkiewicz D, Rusin M, Pawlas M, Czarny M, Chorazy M. Butkiewicz D, et al. Postepy Hig Med Dosw. 2002;56(4):485-98. Postepy Hig Med Dosw. 2002. PMID: 12418414 Review. Polish.
• Bacterial DNA repair genes and their eukaryotic homologues: 4. The role of nucleotide excision DNA repair (NER) system in mammalian cells.
  Maddukuri L, Dudzińska D, Tudek B. Maddukuri L, et al. Acta Biochim Pol. 2007;54(3):469-82. Epub 2007 Sep 23. Acta Biochim Pol. 2007. PMID: 17893751 Review.
• Multiple involvement of nucleotide excision repair enzymes: clinical manifestations of molecular intricacies.
  Jaspers NG. Jaspers NG. Cytokines Mol Ther. 1996 Jun;2(2):115-9. Cytokines Mol Ther. 1996. PMID: 9384696 Review.
• The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair.
  Friedberg EC. Friedberg EC. DNA Repair (Amst). 2004 Feb 3;3(2):183, 195. DNA Repair (Amst). 2004. PMID: 14706352
• Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.
  Wijnhoven SW, Hoogervorst EM, de Waard H, van der Horst GT, van Steeg H. Wijnhoven SW, et al. Mutat Res. 2007 Jan 3;614(1-2):77-94. doi: 10.1016/j.mrfmmm.2005.12.018. Mutat Res. 2007. PMID: 16769089 Review.

Cited by

• Pharmacogenetic role of ERCC1 genetic variants in treatment response of platinum-based chemotherapy among advanced non-small cell lung cancer patients.
  Yu D, Shi J, Sun T, Du X, Liu L, Zhang X, Lu C, Tang X, Li M, Xiao L, Zhang Z, Yuan Q, Yang M. Yu D, et al. Tumour Biol. 2012 Jun;33(3):877-84. doi: 10.1007/s13277-011-0314-y. Epub 2012 Jan 17. Tumour Biol. 2012. PMID: 22249976
• Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus.
  Souliotis VL, Vougas K, Gorgoulis VG, Sfikakis PP. Souliotis VL, et al. Arthritis Res Ther. 2016 Aug 4;18(1):182. doi: 10.1186/s13075-016-1081-3. Arthritis Res Ther. 2016. PMID: 27492607 Free PMC article.
• Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.
  He J, Xu Y, Qiu LX, Li J, Zhou XY, Sun MH, Wang JC, Yang YJ, Jin L, Wei QY, Wang Y. He J, et al. PLoS One. 2012;7(11):e49308. doi: 10.1371/journal.pone.0049308. Epub 2012 Nov 15. PLoS One. 2012. PMID: 23166636 Free PMC article.
• XPC gene polymorphisms contribute to bladder cancer susceptibility: a meta-analysis.
  Dai QS, Hua RX, Zeng RF, Long JT, Peng ZW. Dai QS, et al. Tumour Biol. 2014 Jan;35(1):447-53. doi: 10.1007/s13277-013-1062-y. Epub 2013 Aug 6. Tumour Biol. 2014. PMID: 23918308
• Development of cancer-initiating cells and immortalized cells with genomic instability.
  Yoshioka K, Atsumi Y, Nakagama H, Teraoka H. Yoshioka K, et al. World J Stem Cells. 2015 Mar 26;7(2):483-9. doi: 10.4252/wjsc.v7.i2.483. World J Stem Cells. 2015. PMID: 25815132 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group