Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors - PubMed (original) (raw)
Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors
Ivana Cecic et al. Cancer Lett. 2002.
Abstract
Photodynamic therapy (PDT) of tumors elicits a strong host immune response and one of its manifestations is a pronounced neutrophilia. By blocking their function prior to Photofrin-based PDT of mouse EMT6 tumors, we have identified multiple mediators whose regulated action is responsible for this neutrophilia. In addition to complement fragments (direct mediators) released as a consequence of PDT-induced complement activation, there are at least a dozen secondary mediators that all arise as a result of complement activity. The latter include cytokines IL-1beta, TNF-alpha, IL-6, IL-10, G-CSF and KC, thromboxane, prostaglandins, leukotrienes, histamine, and coagulation factors.
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