Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats - PubMed (original) (raw)
Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
Juan Duarte et al. J Hypertens. 2002 Sep.
Abstract
Objectives: The present study analysed, for the first time, the effects of the flavonoid quercetin in rats after chronic inhibition of nitric oxide (NO) synthesis with Nomega-nitro-L-arginine methyl ester (L-NAME).
Design: Rats were divided randomly into five different treatment groups for 6 weeks: (1) vehicle (control, 1 ml of 1% methylcellulose once daily); (2) vehicle plus L-NAME (75 mg/100 ml in drinking water); (3) quercetin (10 mg/kg p.o. once daily); (4) quercetin (5 mg/kg p.o.) plus L-NAME; and (5) quercetin (10 mg/kg p.o.) plus L-NAME.
Methods: The evolution of systolic blood pressure, morphological variables, proteinuria, plasma malondialdehyde and nitrite and nitrate concentrations, hepatic glutathione and malondialdehyde content, glutathione enzymes activity and vascular reactivity at the end of the experiment were analysed.
Results: Quercetin markedly inhibited the development of L-NAME-induced hypertension. This effect was accompanied by a partial or full prevention of most of the effects induced by L-NAME, such as: (1) increases in the left ventricular and kidney weight indices; (2) proteinuria; (3) renal histological lesions, including hyaline arteriopathy and thickening of the vascular wall with moderate decrease of the lumen; (4) increased endothelium-dependent contraction; (5) increased vascular thromboxane B2 (TXB2) synthesis; (6) reduced plasma concentrations of nitrites plus nitrates (NOx); (7) increased plasma and hepatic malondialdehyde (MDA) concentrations; and (8) reduced glutathione peroxidase activity. In most cases these effects were dose dependent, but none of them were observed in normotensive animals.
Conclusions: This study confirms and extends the previous evidence about the antihypertensive effects and end-organ protection of the flavonoid quercetin in animal models of hypertension.
Comment in
- Antihypertensive effect and end-organ protection of flavonoids: some insights, more questions.
Cosentino F, Volpe M. Cosentino F, et al. J Hypertens. 2002 Sep;20(9):1721-4. doi: 10.1097/00004872-200209000-00013. J Hypertens. 2002. PMID: 12195110 Review. No abstract available.
Similar articles
- Effects of chronic quercetin treatment in experimental renovascular hypertension.
García-Saura MF, Galisteo M, Villar IC, Bermejo A, Zarzuelo A, Vargas F, Duarte J. García-Saura MF, et al. Mol Cell Biochem. 2005 Feb;270(1-2):147-55. doi: 10.1007/s11010-005-4503-0. Mol Cell Biochem. 2005. PMID: 15792364 - Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.
Gómez-Guzmán M, Jiménez R, Sánchez M, Romero M, O'Valle F, Lopez-Sepulveda R, Quintela AM, Galindo P, Zarzuelo MJ, Bailón E, Delpón E, Perez-Vizcaino F, Duarte J. Gómez-Guzmán M, et al. Br J Nutr. 2011 Nov;106(9):1337-48. doi: 10.1017/S0007114511004314. Epub 2011 Sep 13. Br J Nutr. 2011. PMID: 21910946 - Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Khattab M, Ahmad M, Al-Shabanah OA, Raza M. Khattab M, et al. Recept Channels. 2004;10(5-6):147-57. doi: 10.3109/10606820490936141. Recept Channels. 2004. PMID: 15989079 - Antihypertensive effects of the flavonoid quercetin.
Perez-Vizcaino F, Duarte J, Jimenez R, Santos-Buelga C, Osuna A. Perez-Vizcaino F, et al. Pharmacol Rep. 2009 Jan-Feb;61(1):67-75. doi: 10.1016/s1734-1140(09)70008-8. Pharmacol Rep. 2009. PMID: 19307694 Review. - Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation.
Amadi PU, Agomuo EN, Adumekwe CW. Amadi PU, et al. J Basic Clin Physiol Pharmacol. 2020 Jul 11;31(5):/j/jbcpp.2020.31.issue-5/jbcpp-2019-0116/jbcpp-2019-0116.xml. doi: 10.1515/jbcpp-2019-0116. J Basic Clin Physiol Pharmacol. 2020. PMID: 32653874 Review.
Cited by
- The effects of a multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.
Kappus RM, Curry CD, McAnulty S, Welsh J, Morris D, Nieman DC, Soukup J, Collier SR. Kappus RM, et al. Oxid Med Cell Longev. 2011;2011:210798. doi: 10.1155/2011/210798. Epub 2011 Dec 4. Oxid Med Cell Longev. 2011. PMID: 22191012 Free PMC article. Clinical Trial. - The renoprotective effect of L-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression.
Zambrano S, Blanca AJ, Ruiz-Armenta MV, Miguel-Carrasco JL, Revilla E, Santa-María C, Mate A, Vázquez CM. Zambrano S, et al. Eur J Nutr. 2013 Sep;52(6):1649-59. doi: 10.1007/s00394-012-0470-x. Epub 2012 Dec 6. Eur J Nutr. 2013. PMID: 23223967 - Sub-acute effect of N(G)-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices in rats: Protective effects of Kolaviron and extract of Curcuma longa L.
Adaramoye OA, Nwosu IO, Farombi EO. Adaramoye OA, et al. Pharmacognosy Res. 2012 Jul;4(3):127-33. doi: 10.4103/0974-8490.99071. Pharmacognosy Res. 2012. PMID: 22923949 Free PMC article. - Evaluation of antihypertensive potential of Ficus carica fruit.
Alamgeer, Iman S, Asif H, Saleem M. Alamgeer, et al. Pharm Biol. 2017 Dec;55(1):1047-1053. doi: 10.1080/13880209.2017.1278611. Pharm Biol. 2017. PMID: 28187689 Free PMC article. - Roles of Averrhoa bilimbi Extract in Increasing Serum Nitric Oxide Concentration and Vascular Dilatation of Ethanol-Induced Hypertensive Rats.
Solfaine R, Muniroh L, Sadarman, Apriza, Irawan A. Solfaine R, et al. Prev Nutr Food Sci. 2021 Jun 30;26(2):186-191. doi: 10.3746/pnf.2021.26.2.186. Prev Nutr Food Sci. 2021. PMID: 34316483 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources