Use of oral contraceptives and breast cancer risk: The Norwegian-Swedish Women's Lifestyle and Health Cohort Study - PubMed (original) (raw)

Comparative Study

. 2002 Nov;11(11):1375-81.

Affiliations

• PMID: 12433714

Comparative Study

Use of oral contraceptives and breast cancer risk: The Norwegian-Swedish Women's Lifestyle and Health Cohort Study

Merethe Kumle et al. Cancer Epidemiol Biomarkers Prev. 2002 Nov.

Abstract

Current use of oral contraceptives (OCs) has been reported to increase breast cancer risk slightly. In 1991/1992, a prospective cohort study specifically designed to examine the role of hormonal contraceptives in relation to breast cancer was conducted in Norway and Sweden. This study was entitled Women's Lifestyle and Health. Of 196,000 invited women aged 30-49 years, 106,844 women answered a 4-page questionnaire. Altogether, 103,027 women providing information on contraceptive use were included in the analysis presented here, and 1,008 primary invasive breast cancers were diagnosed throughout 1999 (end of follow-up). Proportional hazard regression was used to calculate relative risks (RRs) with adjustment for age and other possible confounders. An increased breast cancer risk was observed among women who were current/recent users of OCs of any type at the start of follow-up [RR, 1.6; 96% confidence interval (CI), 1.2-2.1]. Current/recent use (i.e., use in the year preceding cohort enrolment) of combined OCs (RR, 1.5; 95% CI, 1.0-2.0) and progestin-only pills (RR, 1.6; 95% CI, 1.0-2.4) entailed similar levels of increased risk. An increased risk of borderline significance was found among short-term (i.e., less than 13 months) users before age 20 years (RR, 1.3; 95% CI, 1.0-1.7) and before first full-term pregnancy (RR, 1.4; 95% CI, 1.0-1.8). Long-term users of OCs were at a higher risk of breast cancer than never users (test for trend, P = 0.005). Current/recent use of OCs is associated with an increased breast cancer risk. Use of combined OCs and progestin-only pills seem to increase the risk at the same level.

PubMed Disclaimer

Similar articles

• Breast cancer among young U.S. women in relation to oral contraceptive use.
  White E, Malone KE, Weiss NS, Daling JR. White E, et al. J Natl Cancer Inst. 1994 Apr 6;86(7):505-14. doi: 10.1093/jnci/86.7.505. J Natl Cancer Inst. 1994. PMID: 8133534
• Exogenous progestins and breast cancer.
  Stanford JL, Thomas DB. Stanford JL, et al. Epidemiol Rev. 1993;15(1):98-107. doi: 10.1093/oxfordjournals.epirev.a036120. Epidemiol Rev. 1993. PMID: 8405216 Review.
• Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway.
  Meirik O, Lund E, Adami HO, Bergström R, Christoffersen T, Bergsjö P. Meirik O, et al. Lancet. 1986 Sep 20;2(8508):650-4. doi: 10.1016/s0140-6736(86)90166-2. Lancet. 1986. PMID: 2876135
• Oral contraceptives and breast cancer.
  Brinton LA, Hoover R, Szklo M, Fraumeni JF Jr. Brinton LA, et al. Int J Epidemiol. 1982 Dec;11(4):316-22. doi: 10.1093/ije/11.4.316. Int J Epidemiol. 1982. PMID: 7152784
• Estrogen and progestin components of oral contraceptives: relationship to vascular disease.
  Carr BR, Ory H. Carr BR, et al. Contraception. 1997 May;55(5):267-72. doi: 10.1016/s0010-7824(97)00029-2. Contraception. 1997. PMID: 9220222 Review.

Cited by

• A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women's lifestyle and health cohort.
  Nur U, El Reda D, Hashim D, Weiderpass E. Nur U, et al. BMC Cancer. 2019 Aug 14;19(1):807. doi: 10.1186/s12885-019-5985-6. BMC Cancer. 2019. PMID: 31412822 Free PMC article.
• Progesterone receptor isoform functions in normal breast development and breast cancer.
  Kariagina A, Aupperlee MD, Haslam SZ. Kariagina A, et al. Crit Rev Eukaryot Gene Expr. 2008;18(1):11-33. doi: 10.1615/critreveukargeneexpr.v18.i1.20. Crit Rev Eukaryot Gene Expr. 2008. PMID: 18197783 Free PMC article. Review.
• Association of Nongenetic Factors With Breast Cancer Risk in Genetically Predisposed Groups of Women in the UK Biobank Cohort.
  Al Ajmi K, Lophatananon A, Mekli K, Ollier W, Muir KR. Al Ajmi K, et al. JAMA Netw Open. 2020 Apr 1;3(4):e203760. doi: 10.1001/jamanetworkopen.2020.3760. JAMA Netw Open. 2020. PMID: 32329772 Free PMC article.
• Prospective study of coffee consumption and all-cause, cancer, and cardiovascular mortality in Swedish women.
  Löf M, Sandin S, Yin L, Adami HO, Weiderpass E. Löf M, et al. Eur J Epidemiol. 2015 Sep;30(9):1027-34. doi: 10.1007/s10654-015-0052-3. Epub 2015 Jun 16. Eur J Epidemiol. 2015. PMID: 26076920
• Oral contraceptive use and breast cancer: a prospective study of young women.
  Hunter DJ, Colditz GA, Hankinson SE, Malspeis S, Spiegelman D, Chen W, Stampfer MJ, Willett WC. Hunter DJ, et al. Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2496-502. doi: 10.1158/1055-9965.EPI-10-0747. Epub 2010 Aug 27. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20802021 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information