The circadian clock: a manager of biochemical processes within the organism - PubMed (original) (raw)
Review
The circadian clock: a manager of biochemical processes within the organism
D Holzberg et al. J Neuroendocrinol. 2003 Apr.
Abstract
The periodic succession of night and day has influenced life on earth for millions of years. Many organisms have "internalized" this periodic change in the form of the circadian clock. Its main function is to organize the time course of biochemical, physiological and behavioural processes thereby optimizing an organism's performance in anticipating changing environmental conditions. Therefore, it is important to understand the underlying mechanisms that connect the core pacemaker, which is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, with peripheral organs. Several laboratories set out to identify genes that are under the influence of the circadian clock. It appears that the circadian clock coordinates transcription of key metabolic pathways thereby orchestrating the time course of physiological and behavioural processes. We review these investigations and put our experiments, the comparison of gene expression in SCN tissue of Per2 mutant and wild-type mice, in the context of these findings.
Similar articles
- Expression of mCLOCK and other circadian clock-relevant proteins in the mouse suprachiasmatic nuclei.
Maywood ES, O'Brien JA, Hastings MH. Maywood ES, et al. J Neuroendocrinol. 2003 Apr;15(4):329-34. doi: 10.1046/j.1365-2826.2003.00971.x. J Neuroendocrinol. 2003. PMID: 12622829 - [Synchronization and genetic redundancy in circadian clocks].
Dardente H. Dardente H. Med Sci (Paris). 2008 Mar;24(3):270-6. doi: 10.1051/medsci/2008243270. Med Sci (Paris). 2008. PMID: 18334175 Review. French. - Rhythmic clock gene expression in heart, kidney and some brain nuclei involved in blood pressure control in hypertensive TGR(mREN-2)27 rats.
Herichová I, Mravec B, Stebelová K, Krizanová O, Jurkovicová D, Kvetnanský R, Zeman M. Herichová I, et al. Mol Cell Biochem. 2007 Feb;296(1-2):25-34. doi: 10.1007/s11010-006-9294-4. Epub 2006 Aug 15. Mol Cell Biochem. 2007. PMID: 16909304 - Coordinated transcription of key pathways in the mouse by the circadian clock.
Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. Panda S, et al. Cell. 2002 May 3;109(3):307-20. doi: 10.1016/s0092-8674(02)00722-5. Cell. 2002. PMID: 12015981 - Flies and fish: birds of a feather.
Tamai TK, Vardhanabhuti V, Arthur S, Foulkes NS, Whitmore D. Tamai TK, et al. J Neuroendocrinol. 2003 Apr;15(4):344-9. doi: 10.1046/j.1365-2826.2003.00974.x. J Neuroendocrinol. 2003. PMID: 12622832 Review.
Cited by
- Neel revisited: the adipocyte, seasonality and type 2 diabetes.
Scott EM, Grant PJ. Scott EM, et al. Diabetologia. 2006 Jul;49(7):1462-6. doi: 10.1007/s00125-006-0280-x. Epub 2006 May 17. Diabetologia. 2006. PMID: 16752164 Review. - Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster.
Ruby CL, Brager AJ, DePaul MA, Prosser RA, Glass JD. Ruby CL, et al. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R729-37. doi: 10.1152/ajpregu.00268.2009. Epub 2009 Jun 24. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19553498 Free PMC article. - The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia.
Vitale JA, Bonato M, La Torre A, Banfi G. Vitale JA, et al. Int J Mol Sci. 2019 Sep 3;20(17):4318. doi: 10.3390/ijms20174318. Int J Mol Sci. 2019. PMID: 31484440 Free PMC article. Review. - Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue.
Zhang X, Zarbl H. Zhang X, et al. Cancer Prev Res (Phila). 2008 Jul;1(2):119-27. doi: 10.1158/1940-6207.CAPR-08-0036. Cancer Prev Res (Phila). 2008. PMID: 19122877 Free PMC article. - Per3 expression in different tissues of Cebus apella.
Sabino FC, de Oliveira JA, Pedrazzoli M. Sabino FC, et al. Sleep Sci. 2016 Oct-Dec;9(4):262-265. doi: 10.1016/j.slsci.2016.12.002. Epub 2016 Dec 13. Sleep Sci. 2016. PMID: 28154738 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources