5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala - PubMed (original) (raw)
5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala
S Sugita et al. Neuron. 1992 Jan.
Abstract
A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.
Similar articles
- Modulation of intrinsic circuits by serotonin 5-HT3 receptors in developing ferret visual cortex.
Roerig B, Katz LC. Roerig B, et al. J Neurosci. 1997 Nov 1;17(21):8324-38. doi: 10.1523/JNEUROSCI.17-21-08324.1997. J Neurosci. 1997. PMID: 9334407 Free PMC article. - Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro.
Pan ZZ, Wessendorf MW, Williams JT. Pan ZZ, et al. Neuroscience. 1993 May;54(2):421-9. doi: 10.1016/0306-4522(93)90263-f. Neuroscience. 1993. PMID: 8101640 - Glutamatergic and non-glutamatergic responses evoked in neonatal rat lumbar motoneurons on stimulation of the lateroventral spinal cord surface.
Elliott P, Wallis DI. Elliott P, et al. Neuroscience. 1993 Sep;56(1):189-97. doi: 10.1016/0306-4522(93)90573-x. Neuroscience. 1993. PMID: 7901806 - The central 5-HT3 receptor in CNS disorders.
Bloom FE, Morales M. Bloom FE, et al. Neurochem Res. 1998 May;23(5):653-9. doi: 10.1023/a:1022486705184. Neurochem Res. 1998. PMID: 9566603 Review. - Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons.
Galligan JJ. Galligan JJ. Behav Brain Res. 1996;73(1-2):199-201. doi: 10.1016/0166-4328(96)00096-4. Behav Brain Res. 1996. PMID: 8788502 Review.
Cited by
- Mechanisms of neuromodulatory volume transmission.
Özçete ÖD, Banerjee A, Kaeser PS. Özçete ÖD, et al. Mol Psychiatry. 2024 May 24. doi: 10.1038/s41380-024-02608-3. Online ahead of print. Mol Psychiatry. 2024. PMID: 38789677 Review. - Functional neuroanatomy of monoaminergic systems in the basolateral nuclear complex of the amygdala: Neuronal targets, receptors, and circuits.
McDonald AJ. McDonald AJ. J Neurosci Res. 2023 Sep;101(9):1409-1432. doi: 10.1002/jnr.25201. Epub 2023 May 11. J Neurosci Res. 2023. PMID: 37166098 Free PMC article. Review. - Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors.
Do HQ, Jansen M. Do HQ, et al. J Gen Physiol. 2023 Jun 5;155(6):e202213305. doi: 10.1085/jgp.202213305. Epub 2023 Apr 7. J Gen Physiol. 2023. PMID: 37026993 Free PMC article. - Effect of ramosetron, a 5-HT3 receptor antagonist on the severity of seizures and memory impairment in electrical amygdala kindled rats.
Sayahi Z, Komaki A, Saidi Jam M, Karimi SA, Raoufi S, Mardani P, Naderishahab M, Sarihi A, Mirnajafi-Zadeh J. Sayahi Z, et al. J Physiol Sci. 2022 Jan 16;72(1):1. doi: 10.1186/s12576-022-00825-5. J Physiol Sci. 2022. PMID: 35034601 Free PMC article. - Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3.
Gibbs E, Chakrapani S. Gibbs E, et al. Subcell Biochem. 2021;96:373-408. doi: 10.1007/978-3-030-58971-4_11. Subcell Biochem. 2021. PMID: 33252737 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases