The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes - PubMed (original) (raw)
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes
S BOYDEN. J Exp Med. 1962.
Abstract
An in vitro technique is described for assessing the chemotactic activity of soluble substances on motile cells. Antibody-antigen mixtures when incubated (37 degrees C) in medium containing fresh (i.e. non-inactivated) normal rabbit serum exert a strong chemotactic effect on rabbit polymorphonuclear leucocytes. Results are described which indicate that, when antibody-antigen complexes are incubated (37 degrees C) in fresh serum, a heat-stable (56 degrees C) substance (or substances) is produced which acts directly as a chemotactic stimulus on the polymorphs. This heat-stable chemotactic substance is not produced when antibody-antigen complexes are incubated in serum which has been heated at 56 degrees C for 30 minutes.
Similar articles
- THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.
WARD PA, COCHRANE CG, MUELLER-EBERHARD HJ. WARD PA, et al. J Exp Med. 1965 Aug 1;122(2):327-46. doi: 10.1084/jem.122.2.327. J Exp Med. 1965. PMID: 14316948 Free PMC article. - Chemotaxis for polymorphonuclear leucocytes induced by soluble antigen- antibody complexes.
Leung-Tack J, Maillard J, Voisin GA. Leung-Tack J, et al. Immunology. 1977 Dec;33(6):937-45. Immunology. 1977. PMID: 591003 Free PMC article. - Immunologic response of neonatal and older rabbits to antigens of rabbit leucocytes.
HARRIS TN, HARRIS S, FARBER MB. HARRIS TN, et al. J Exp Med. 1962 Nov 1;116(5):575-88. doi: 10.1084/jem.116.5.575. J Exp Med. 1962. PMID: 13952966 Free PMC article. - STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. I. STRUCTURAL STUDIES.
COCHRANE CG. COCHRANE CG. J Exp Med. 1963 Oct 1;118(4):489-502. doi: 10.1084/jem.118.4.489. J Exp Med. 1963. PMID: 14067901 Free PMC article. - NATURE OF THE REACTION BETWEEN ANTIGEN AND ANTIBODY.
HUGHES-JONES NC. HUGHES-JONES NC. Br Med Bull. 1963 Sep;19:171-7. doi: 10.1093/oxfordjournals.bmb.a070052. Br Med Bull. 1963. PMID: 14062505 Review. No abstract available.
Cited by
- Dissecting the inter-substrate navigation of migrating glioblastoma cells with the stripe assay reveals a causative role of ROCK.
Mertsch S, Oellers P, Wendling M, Stracke W, Thanos S. Mertsch S, et al. Mol Neurobiol. 2013 Aug;48(1):169-79. doi: 10.1007/s12035-013-8429-3. Epub 2013 Feb 24. Mol Neurobiol. 2013. PMID: 23436115 Free PMC article. - Analysis of trunk neural crest cell migration using a modified Zigmond chamber assay.
Walheim CC, Zanin JP, de Bellard ME. Walheim CC, et al. J Vis Exp. 2012 Jan 19;(59):3330. doi: 10.3791/3330. J Vis Exp. 2012. PMID: 22297254 Free PMC article. - Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells.
Bapat AA, Munoz RM, Von Hoff DD, Han H. Bapat AA, et al. PLoS One. 2016 Oct 28;11(10):e0165586. doi: 10.1371/journal.pone.0165586. eCollection 2016. PLoS One. 2016. PMID: 27792755 Free PMC article. - Selection of chemotaxis mutants of Dictyostelium discoideum.
Segall JE, Fisher PR, Gerisch G. Segall JE, et al. J Cell Biol. 1987 Jan;104(1):151-61. doi: 10.1083/jcb.104.1.151. J Cell Biol. 1987. PMID: 3793759 Free PMC article. - Inhibition of human eosinophil chemotaxis by IgA paraproteins.
Reed KJ, Van Epps DE, Williams RC Jr. Reed KJ, et al. Inflammation. 1979 Sep;3(4):405-16. doi: 10.1007/BF00913498. Inflammation. 1979. PMID: 116966
References
- Physiol Rev. 1954 Jul;34(3):529-62 - PubMed
- Proc R Soc Med. 1959 May;52(5):315-22 - PubMed
- J Exp Med. 1960 Mar 1;111:309-22 - PubMed
- J Natl Cancer Inst. 1958 Jul;21(1):137-61 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources