Modulation of gut physiology through enteric toxins - PubMed (original) (raw)

Review

. 2003 Nov;253(1-2):15-9.

doi: 10.1023/a:1026088915240.

Affiliations

• PMID: 14619951
• DOI: 10.1023/a:1026088915240

Review

Modulation of gut physiology through enteric toxins

Tanvir Kaur et al. Mol Cell Biochem. 2003 Nov.

Abstract

Diarrheal diseases caused by microorganisms and their toxins are a major cause of mortality and morbidity throughout the world. Acute diarrhea is mainly caused due to increased intestinal secretion, commonly as a result of infection with enterotoxin producing organisms (enterotoxigenic Escherichia coli, Vibrio cholera) or due to decreased intestinal absorption from infection with organisms that damage the intestinal epithelium (enteropathogenic E. coli sp., Shigella sp., Salmonella sp.) The studies of the impact of enteric pathogens and their virulence factors exert their effect by producing toxins, called bacterial toxins. The protein toxins are produced by diverse group of bacteria. Most of the bacterial toxins exert their effect through involvement of ADP-ribosylation proteins; otherwise essential for several cellular functions while other toxins involve guanylate cyclase systems or calcium and protein kinases for their ultimate action.

PubMed Disclaimer

Similar articles

• Bacterial enteric infections and vaccine development.
  Holmgren J, Svennerholm AM. Holmgren J, et al. Gastroenterol Clin North Am. 1992 Jun;21(2):283-302. Gastroenterol Clin North Am. 1992. PMID: 1512046 Review.
• Novel targets for the pharmacotherapy of diarrhoea: a view for the millennium.
  Farthing MJ. Farthing MJ. J Gastroenterol Hepatol. 2000 Oct;15 Suppl:G38-45. doi: 10.1046/j.1440-1746.2000.02264.x. J Gastroenterol Hepatol. 2000. PMID: 11100992 Review.
• [Bacterial enterotoxins: structure, mode of action].
  Lucas F, Popoff M, Corthier G. Lucas F, et al. Ann Rech Vet. 1991;22(2):147-62. Ann Rech Vet. 1991. PMID: 1897866 Review. French.
• Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.
  Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Pattison AM, et al. Infect Immun. 2016 Sep 19;84(10):3083-91. doi: 10.1128/IAI.00639-16. Print 2016 Oct. Infect Immun. 2016. PMID: 27481254 Free PMC article.
• Receptors and recognition mechanisms in intestinal infection.
  Farthing MJ. Farthing MJ. Trans R Soc Trop Med Hyg. 1985;79(5):569-76. doi: 10.1016/0035-9203(85)90160-9. Trans R Soc Trop Med Hyg. 1985. PMID: 2869598 Review.

Cited by

• Novel role of folate (vitamin B9) released by fermenting bacteria under Human Intestine like environment.
  Nara S, Parasher G, Malhotra BD, Rawat M. Nara S, et al. Sci Rep. 2023 Nov 18;13(1):20226. doi: 10.1038/s41598-023-47243-0. Sci Rep. 2023. PMID: 37980374 Free PMC article.
• Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis.
  Broderick NA, Raffa KF, Handelsman J. Broderick NA, et al. BMC Microbiol. 2010 Apr 27;10:129. doi: 10.1186/1471-2180-10-129. BMC Microbiol. 2010. PMID: 20423490 Free PMC article.
• Early Intervention With Cecal Fermentation Broth Regulates the Colonization and Development of Gut Microbiota in Broiler Chickens.
  Gong Y, Yang H, Wang X, Xia W, Lv W, Xiao Y, Zou X. Gong Y, et al. Front Microbiol. 2019 Jun 25;10:1422. doi: 10.3389/fmicb.2019.01422. eCollection 2019. Front Microbiol. 2019. PMID: 31293552 Free PMC article.
• Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice.
  van Ampting MT, Loonen LM, Schonewille AJ, Konings I, Vink C, Iovanna J, Chamaillard M, Dekker J, van der Meer R, Wells JM, Bovee-Oudenhoven IM. van Ampting MT, et al. Infect Immun. 2012 Mar;80(3):1115-20. doi: 10.1128/IAI.06165-11. Epub 2012 Jan 17. Infect Immun. 2012. PMID: 22252863 Free PMC article.
• Physiological Concentration of Exogenous Lactate Reduces Antimycin A Triggered Oxidative Stress in Intestinal Epithelial Cell Line IPEC-1 and IPEC-J2 In Vitro.
  Kahlert S, Junnikkala S, Renner L, Hynönen U, Hartig R, Nossol C, Barta-Böszörményi A, Dänicke S, Souffrant WB, Palva A, Rothkötter HJ, Kluess J. Kahlert S, et al. PLoS One. 2016 Apr 7;11(4):e0153135. doi: 10.1371/journal.pone.0153135. eCollection 2016. PLoS One. 2016. PMID: 27054581 Free PMC article.

References

1. 1. Pharmacol Ther. 1981;15(3):403-38 - PubMed
2. 1. Science. 1992 Jun 12;256(5063):1524-5 - PubMed
3. 1. Mol Cell Biochem. 1999 Jun;196(1-2):175-81 - PubMed
4. 1. Clin Microbiol Rev. 1998 Jan;11(1):142-201 - PubMed
5. 1. Biochim Biophys Acta. 1991 Oct 21;1097(3):171-6 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.