Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages - PubMed (original) (raw)
Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages
David Comas et al. Eur J Hum Genet. 2004 Jun.
Abstract
Mitochondrial DNA (mtDNA) lineages of 232 individuals from 12 Central Asian populations were sequenced for both control region hypervariable segments, and additional informative sites in the coding region were also determined. Most of the mtDNA lineages belong to branches of the haplogroups with an eastern Eurasian (A, B, C, D, F, G, Y, and M haplogroups) or a western Eurasian (HV, JT, UK, I, W, and N haplogroups) origin, with a small fraction of Indian M lineages. This suggests that the extant genetic variation found in Central Asia is the result of admixture of already differentiated populations from eastern and western Eurasia. Nonetheless, two groups of lineages, D4c and G2a, seem to have expanded from Central Asia and might have their Y-chromosome counterpart in lineages belonging to haplotype P(xR1a). The present results suggest that the mtDNA found out of Africa might be the result of a maturation phase, presumably in the Middle East or eastern Africa, that led to haplogroups M and N, and subsequently expanded into Eurasia, yielding a geographically structured group of external branches of these two haplogroups in western and eastern Eurasia, Central Asia being a contact zone between two differentiated groups of peoples.
Similar articles
- Phylogeography of mitochondrial DNA and Y-chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India.
Sahoo S, Kashyap VK. Sahoo S, et al. Am J Phys Anthropol. 2006 Sep;131(1):84-97. doi: 10.1002/ajpa.20399. Am J Phys Anthropol. 2006. PMID: 16485297 - Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans.
Metspalu M, Kivisild T, Metspalu E, Parik J, Hudjashov G, Kaldma K, Serk P, Karmin M, Behar DM, Gilbert MT, Endicott P, Mastana S, Papiha SS, Skorecki K, Torroni A, Villems R. Metspalu M, et al. BMC Genet. 2004 Aug 31;5:26. doi: 10.1186/1471-2156-5-26. BMC Genet. 2004. PMID: 15339343 Free PMC article. - [Phylogeografic analysis of mitochondrial DNA Nogays: the high level of mixture of maternal lineages from Eastern and Western Eurasia].
Bermisheva MA, Kutuev IA, Korshunova TIu, Dubova NA, Villems R, Khusnutdinova EK. Bermisheva MA, et al. Mol Biol (Mosk). 2004 Jul-Aug;38(4):617-24. Mol Biol (Mosk). 2004. PMID: 15456133 Russian. - Review of Croatian genetic heritage as revealed by mitochondrial DNA and Y chromosomal lineages.
Pericić M, Barać Lauc L, Martinović Klarić I, Janićijević B, Rudan P. Pericić M, et al. Croat Med J. 2005 Aug;46(4):502-13. Croat Med J. 2005. PMID: 16100752 Review. - [Polymorphism of human mitochondrial DNA].
Bermisheva MA, Viktorova TV, Khusnutdinova EK. Bermisheva MA, et al. Genetika. 2003 Aug;39(8):1013-25. Genetika. 2003. PMID: 14515456 Review. Russian.
Cited by
- Ancestral Origins and Admixture History of Kazakhs.
Lei C, Liu J, Zhang R, Pan Y, Lu Y, Gao Y, Ma X, Yang Y, Guan Y, Mamatyusupu D, Xu S. Lei C, et al. Mol Biol Evol. 2024 Jul 3;41(7):msae144. doi: 10.1093/molbev/msae144. Mol Biol Evol. 2024. PMID: 38995236 Free PMC article. - Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses.
Ferreira T, Rodriguez S. Ferreira T, et al. Genes (Basel). 2024 May 12;15(5):617. doi: 10.3390/genes15050617. Genes (Basel). 2024. PMID: 38790246 Free PMC article. Review. - Phylogenetic insights into the genetic legacies of Hungarian-speaking communities in the Carpathian Basin.
Borbély N, Dudás D, Tapasztó A, Dudás-Boda E, Csáky V, Szeifert B, Mende BG, Egyed B, Szécsényi-Nagy A, Pamjav H. Borbély N, et al. Sci Rep. 2024 May 20;14(1):11480. doi: 10.1038/s41598-024-61978-4. Sci Rep. 2024. PMID: 38769390 Free PMC article. - Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.
Askapuli A, Vilar M, Garcia-Ortiz H, Zhabagin M, Sabitov Z, Akilzhanova A, Ramanculov E, Schamiloglu U, Martinez-Hernandez A, Contreras-Cubas C, Barajas-Olmos F, Schurr TG, Zhumadilov Z, Flores-Huacuja M, Orozco L, Hawks J, Saitou N. Askapuli A, et al. PLoS One. 2022 Nov 29;17(11):e0277771. doi: 10.1371/journal.pone.0277771. eCollection 2022. PLoS One. 2022. PMID: 36445929 Free PMC article. - Genetic Relationship Among the Kazakh People Based on Y-STR Markers Reveals Evidence of Genetic Variation Among Tribes and Zhuz.
Khussainova E, Kisselev I, Iksan O, Bekmanov B, Skvortsova L, Garshin A, Kuzovleva E, Zhaniyazov Z, Zhunussova G, Musralina L, Kahbatkyzy N, Amirgaliyeva A, Begmanova M, Seisenbayeva A, Bespalova K, Perfilyeva A, Abylkassymova G, Farkhatuly A, Good SV, Djansugurova L. Khussainova E, et al. Front Genet. 2022 Jan 7;12:801295. doi: 10.3389/fgene.2021.801295. eCollection 2021. Front Genet. 2022. PMID: 35069700 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources