Critical functions for c-Myb at three checkpoints during thymocyte development - PubMed (original) (raw)
doi: 10.1038/ni1085. Epub 2004 Jun 13.
Affiliations
- PMID: 15195090
- DOI: 10.1038/ni1085
Critical functions for c-Myb at three checkpoints during thymocyte development
Timothy P Bender et al. Nat Immunol. 2004 Jul.
Abstract
The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we identify three points at which c-Myb activity is required for normal T cell differentiation: transition through the double-negative 3 stage, survival of preselection CD4(+)CD8(+) thymocytes, and differentiation of CD4 thymocytes. Thus, c-Myb is essential at several stages during T cell development in the thymus.
Similar articles
- c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.
Yuan J, Crittenden RB, Bender TP. Yuan J, et al. J Immunol. 2010 Mar 15;184(6):2793-804. doi: 10.4049/jimmunol.0902846. Epub 2010 Feb 8. J Immunol. 2010. PMID: 20142358 Free PMC article. - Requirement of c-myb in T cell development and in mature T cell function.
Lieu YK, Kumar A, Pajerowski AG, Rogers TJ, Reddy EP. Lieu YK, et al. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14853-8. doi: 10.1073/pnas.0405338101. Epub 2004 Oct 4. Proc Natl Acad Sci U S A. 2004. PMID: 15466706 Free PMC article. - c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.
Maurice D, Hooper J, Lang G, Weston K. Maurice D, et al. EMBO J. 2007 Aug 8;26(15):3629-40. doi: 10.1038/sj.emboj.7601801. Epub 2007 Jul 19. EMBO J. 2007. PMID: 17641686 Free PMC article. - Transcriptional control of T-cell development.
Naito T, Tanaka H, Naoe Y, Taniuchi I. Naito T, et al. Int Immunol. 2011 Nov;23(11):661-8. doi: 10.1093/intimm/dxr078. Epub 2011 Sep 23. Int Immunol. 2011. PMID: 21948191 Review. - The CD4/CD8 lineage decision: integration of signalling pathways.
Basson MA, Zamoyska R. Basson MA, et al. Immunol Today. 2000 Oct;21(10):509-14. doi: 10.1016/s0167-5699(00)01711-4. Immunol Today. 2000. PMID: 11071530 Review. No abstract available.
Cited by
- Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumours.
Srinivasan S, Armitage J, Nilsson J, Waithman J. Srinivasan S, et al. Front Immunol. 2024 Sep 27;15:1412731. doi: 10.3389/fimmu.2024.1412731. eCollection 2024. Front Immunol. 2024. PMID: 39399500 Free PMC article. Review. - Transcriptional network dynamics in early T cell development.
Shin B, Chang SJ, MacNabb BW, Rothenberg EV. Shin B, et al. J Exp Med. 2024 Oct 7;221(10):e20230893. doi: 10.1084/jem.20230893. Epub 2024 Aug 21. J Exp Med. 2024. PMID: 39167073 Free PMC article. Review. - MYB: A Key Transcription Factor in the Hematopoietic System Subject to Many Levels of Control.
Lemma RB, Fuglerud BM, Frampton J, Gabrielsen OS. Lemma RB, et al. Adv Exp Med Biol. 2024;1459:3-29. doi: 10.1007/978-3-031-62731-6_1. Adv Exp Med Biol. 2024. PMID: 39017837 Review. - Stabilization of β-Catenin Directs HEB to Limit Thymic Selection.
Tousinas G, Olumide Emmanuel A, Tracy M, Arnovitz S, Friedman D, Papamarcaki T, Gounari F. Tousinas G, et al. J Immunol. 2024 Sep 1;213(5):641-650. doi: 10.4049/jimmunol.2400160. J Immunol. 2024. PMID: 38958395 - Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia.
Almeida A, T'Sas S, Pagliaro L, Fijalkowski I, Sleeckx W, Van Steenberge H, Zamponi R, Lintermans B, Van Loocke W, Palhais B, Reekmans A, Bardelli V, Demoen L, Reunes L, Deforce D, Van Nieuwerburgh F, Kentsis A, Ntziachristos P, Van Roy N, De Moerloose B, Mecucci C, La Starza R, Roti G, Goossens S, Van Vlierberghe P, Pieters T. Almeida A, et al. Hemasphere. 2024 Mar 10;8(3):e51. doi: 10.1002/hem3.51. eCollection 2024 Mar. Hemasphere. 2024. PMID: 38463444 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials