Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients - PubMed (original) (raw)

Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients

Jann-Tay Wang et al. Emerg Infect Dis. 2004 May.

Abstract

Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.

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Figures

Figure

Figure

The time relationships between the time points of defervescence, initiation of steroid, and when chest radiographic finding as well as various laboratory parameters became most severe. Mean and standard deviation (days) are presented. CXR, chest radiography; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; CRP, C-reactive protein; CK, creatine kinase.

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References

    1. World Health Organization. SARS epidemiology to date [monograph on the Internet]. 2003. [cited April 11, 2003]. Available from: http://www.who.int/csr/sars/epi2003_04_11/en/
    1. World Health Organization Multicentre Collaborative Network for Severe Acute Respiratory Syndrome (SARS) Diagnosis. A multicentre collaboration to investigate the cause of severe acute respiratory syndrome. Lancet. 2003;361:1730–3. 10.1016/S0140-6736(03)13376-4 - DOI - PMC - PubMed
    1. World Health Organization. Cumulative number of reported probable cases of severe acute respiratory syndrome (SARS) [monograph on the Internet]. [cited July 11, 2003]. Available from: http://www.who.int/csr/sars/country/en
    1. Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348:1986–94. 10.1056/NEJMoa030685 - DOI - PubMed
    1. Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, et al. Clinical progression and viral load in a community-outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361:1767–72. 10.1016/S0140-6736(03)13412-5 - DOI - PMC - PubMed

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