Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms - PubMed (original) (raw)
Review
. 2004 Nov;25(11):1387-95.
Affiliations
- PMID: 15525457
Free article
Review
Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
Zhi-bin Lin et al. Acta Pharmacol Sin. 2004 Nov.
Free article
Abstract
Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed anti-tumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum.
Similar articles
- Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice.
Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou S. Gao Y, et al. Immunol Invest. 2005;34(2):171-98. Immunol Invest. 2005. PMID: 15921158 - [Extraction and separation of antitumor components from Ganoderma lucidum (Leyss. ex Fr.) Karst].
Zhao DX, Yang XL, Chen L, Wang BW, Xu JL, Zhu HS. Zhao DX, et al. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):288-90. Zhongguo Zhong Yao Za Zhi. 2000. PMID: 12512451 Chinese. - Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities.
Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Xu Z, et al. Am J Chin Med. 2011;39(1):15-27. doi: 10.1142/S0192415X11008610. Am J Chin Med. 2011. PMID: 21213395 Review. - Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.
Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T. Watanabe K, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. doi: 10.1016/j.bbrc.2011.03.108. Epub 2011 Mar 29. Biochem Biophys Res Commun. 2011. PMID: 21453678 - Ganoderma lucidum (Reishi) in cancer treatment.
Sliva D. Sliva D. Integr Cancer Ther. 2003 Dec;2(4):358-64. doi: 10.1177/1534735403259066. Integr Cancer Ther. 2003. PMID: 14713328 Review.
Cited by
- ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells.
Sohretoglu D, Zhang C, Luo J, Huang S. Sohretoglu D, et al. Signal Transduct Target Ther. 2019 Jun 28;4:21. doi: 10.1038/s41392-019-0056-7. eCollection 2019. Signal Transduct Target Ther. 2019. PMID: 31637001 Free PMC article. - Evaluation of Pb (II) biosorption utilizing sugarcane bagasse colonized by Basidiomycetes.
Palin D Jr, Rufato KB, Linde GA, Colauto NB, Caetano J, Alberton O, Jesus DA, Dragunski DC. Palin D Jr, et al. Environ Monit Assess. 2016 May;188(5):279. doi: 10.1007/s10661-016-5257-8. Epub 2016 Apr 11. Environ Monit Assess. 2016. PMID: 27063515 - Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress.
Zhong D, Wang H, Liu M, Li X, Huang M, Zhou H, Lin S, Lin Z, Yang B. Zhong D, et al. Sci Rep. 2015 Nov 25;5:16910. doi: 10.1038/srep16910. Sci Rep. 2015. PMID: 26603550 Free PMC article. - Bioactivities, isolation and purification methods of polysaccharides from natural products: A review.
Shi L. Shi L. Int J Biol Macromol. 2016 Nov;92:37-48. doi: 10.1016/j.ijbiomac.2016.06.100. Epub 2016 Jul 1. Int J Biol Macromol. 2016. PMID: 27377457 Free PMC article. Review. - Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats.
Laçin N, İzol SB, İpek F, Tuncer MC. Laçin N, et al. Acta Cir Bras. 2019 Nov 25;34(9):e201900904. doi: 10.1590/s0102-865020190090000004. eCollection 2019. Acta Cir Bras. 2019. PMID: 31778526 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources