Genetic analyses from ancient DNA - PubMed (original) (raw)
Review
Genetic analyses from ancient DNA
Svante Pääbo et al. Annu Rev Genet. 2004.
Abstract
About 20 years ago, DNA sequences were separately described from the quagga (a type of zebra) and an ancient Egyptian individual. What made these DNA sequences exceptional was that they were derived from 140- and 2400-year-old specimens. However, ancient DNA research, defined broadly as the retrieval of DNA sequences from museum specimens, archaeological finds, fossil remains, and other unusual sources of DNA, only really became feasible with the advent of techniques for the enzymatic amplification of specific DNA sequences. Today, reports of analyses of specimens hundreds, thousands, and even millions of years old are almost commonplace. But can all these results be believed? In this paper, we critically assess the state of ancient DNA research. In particular, we discuss the precautions and criteria necessary to ascertain to the greatest extent possible that results represent authentic ancient DNA sequences. We also highlight some significant results and areas of promising future research.
Similar articles
- Ancient DNA: using molecular biology to explore the past.
Brown TA, Brown KA. Brown TA, et al. Bioessays. 1994 Oct;16(10):719-26. doi: 10.1002/bies.950161006. Bioessays. 1994. PMID: 7980476 Review. - DNA decay rate in papyri and human remains from Egyptian archaeological sites.
Marota I, Basile C, Ubaldi M, Rollo F. Marota I, et al. Am J Phys Anthropol. 2002 Apr;117(4):310-8. doi: 10.1002/ajpa.10045. Am J Phys Anthropol. 2002. PMID: 11920366 - The retrieval of ancient human DNA sequences.
Handt O, Krings M, Ward RH, Pääbo S. Handt O, et al. Am J Hum Genet. 1996 Aug;59(2):368-76. Am J Hum Genet. 1996. PMID: 8755923 Free PMC article. - Neandertal and Denisovan DNA from Pleistocene sediments.
Slon V, Hopfe C, Weiß CL, Mafessoni F, de la Rasilla M, Lalueza-Fox C, Rosas A, Soressi M, Knul MV, Miller R, Stewart JR, Derevianko AP, Jacobs Z, Li B, Roberts RG, Shunkov MV, de Lumley H, Perrenoud C, Gušić I, Kućan Ž, Rudan P, Aximu-Petri A, Essel E, Nagel S, Nickel B, Schmidt A, Prüfer K, Kelso J, Burbano HA, Pääbo S, Meyer M. Slon V, et al. Science. 2017 May 12;356(6338):605-608. doi: 10.1126/science.aam9695. Epub 2017 Apr 27. Science. 2017. PMID: 28450384 - Ancient DNA: would the real Neandertal please stand up?
Cooper A, Drummond AJ, Willerslev E. Cooper A, et al. Curr Biol. 2004 Jun 8;14(11):R431-3. doi: 10.1016/j.cub.2004.05.037. Curr Biol. 2004. PMID: 15182692 Review.
Cited by
- Toward high-resolution population genomics using archaeological samples.
Morozova I, Flegontov P, Mikheyev AS, Bruskin S, Asgharian H, Ponomarenko P, Klyuchnikov V, ArunKumar G, Prokhortchouk E, Gankin Y, Rogaev E, Nikolsky Y, Baranova A, Elhaik E, Tatarinova TV. Morozova I, et al. DNA Res. 2016 Aug;23(4):295-310. doi: 10.1093/dnares/dsw029. Epub 2016 Jul 19. DNA Res. 2016. PMID: 27436340 Free PMC article. Review. - Sequence Capture and Phylogenetic Utility of Genomic Ultraconserved Elements Obtained from Pinned Insect Specimens.
Blaimer BB, Lloyd MW, Guillory WX, Brady SG. Blaimer BB, et al. PLoS One. 2016 Aug 24;11(8):e0161531. doi: 10.1371/journal.pone.0161531. eCollection 2016. PLoS One. 2016. PMID: 27556533 Free PMC article. - Intestinal helminths as a biomolecular complex in archaeological research.
Flammer PG, Smith AL. Flammer PG, et al. Philos Trans R Soc Lond B Biol Sci. 2020 Nov 23;375(1812):20190570. doi: 10.1098/rstb.2019.0570. Epub 2020 Oct 5. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 33012232 Free PMC article. - Revising the recent evolutionary history of equids using ancient DNA.
Orlando L, Metcalf JL, Alberdi MT, Telles-Antunes M, Bonjean D, Otte M, Martin F, Eisenmann V, Mashkour M, Morello F, Prado JL, Salas-Gismondi R, Shockey BJ, Wrinn PJ, Vasil'ev SK, Ovodov ND, Cherry MI, Hopwood B, Male D, Austin JJ, Hänni C, Cooper A. Orlando L, et al. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21754-9. doi: 10.1073/pnas.0903672106. Epub 2009 Dec 9. Proc Natl Acad Sci U S A. 2009. PMID: 20007379 Free PMC article. - Vertebrate DNA in fecal samples from bonobos and gorillas: evidence for meat consumption or artefact?
Hofreiter M, Kreuz E, Eriksson J, Schubert G, Hohmann G. Hofreiter M, et al. PLoS One. 2010 Feb 25;5(2):e9419. doi: 10.1371/journal.pone.0009419. PLoS One. 2010. PMID: 20195539 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources