Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite - PubMed (original) (raw)

Clinical Trial

Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite

Karine Spiegel et al. Ann Intern Med. 2004.

Abstract

Background: Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours.

Objective: To determine whether partial sleep curtailment, an increasingly prevalent behavior, alters appetite regulation.

Design: Randomized, 2-period, 2-condition crossover clinical study.

Setting: Clinical Research Center, University of Chicago, Chicago, Illinois.

Patients: 12 healthy men (mean age [+/-SD], 22 +/- 2 years; mean body mass index [+/-SD], 23.6 +/- 2.0 kg/m2).

Measurements: Daytime profiles of plasma leptin and ghrelin levels and subjective ratings of hunger and appetite.

Intervention: 2 days of sleep restriction and 2 days of sleep extension under controlled conditions of caloric intake and physical activity.

Results: Sleep restriction was associated with average reductions in the anorexigenic hormone leptin (decrease, 18%; P = 0.04), elevations in the orexigenic factor ghrelin (increase, 28%; P < 0.04), and increased hunger (increase, 24%; P < 0.01) and appetite (increase, 23%; P = 0.01), especially for calorie-dense foods with high carbohydrate content (increase, 33% to 45%; P = 0.02).

Limitations: The study included only 12 young men and did not measure energy expenditure.

Conclusions: Short sleep duration in young, healthy men is associated with decreased leptin levels, increased ghrelin levels, and increased hunger and appetite.

PubMed Disclaimer

Comment in

A good night's sleep: future antidote to the obesity epidemic?
Flier JS, Elmquist JK. Flier JS, et al. Ann Intern Med. 2004 Dec 7;141(11):885-6. doi: 10.7326/0003-4819-141-11-200412070-00014. Ann Intern Med. 2004. PMID: 15583232 No abstract available.

Summary for patients in

Summaries for patients. Sleep duration and levels of hormones that influence hunger.
[No authors listed] [No authors listed] Ann Intern Med. 2004 Dec 7;141(11):I52. doi: 10.7326/0003-4819-141-11-200412070-00004. Ann Intern Med. 2004. PMID: 15583222 No abstract available.

Cited by

Sleep Doesn't Waste Time, It's Good for the Waist Line.
Arora T. Arora T. Sleep. 2015 Aug 1;38(8):1159-60. doi: 10.5665/sleep.4884. Sleep. 2015. PMID: 26194575 Free PMC article. No abstract available.
Food Intake and Sleep Disorders in Children and Adolescents with Obesity.
Calcaterra V, Rossi V, Tagi VM, Baldassarre P, Grazi R, Taranto S, Zuccotti G. Calcaterra V, et al. Nutrients. 2023 Nov 9;15(22):4736. doi: 10.3390/nu15224736. Nutrients. 2023. PMID: 38004130 Free PMC article. Review.
Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association.
St-Onge MP, Grandner MA, Brown D, Conroy MB, Jean-Louis G, Coons M, Bhatt DL; American Heart Association Obesity, Behavior Change, Diabetes, and Nutrition Committees of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; and Stroke Council. St-Onge MP, et al. Circulation. 2016 Nov 1;134(18):e367-e386. doi: 10.1161/CIR.0000000000000444. Epub 2016 Sep 19. Circulation. 2016. PMID: 27647451 Free PMC article. Review.
Biological Rhythm and Chronotype: New Perspectives in Health.
Montaruli A, Castelli L, Mulè A, Scurati R, Esposito F, Galasso L, Roveda E. Montaruli A, et al. Biomolecules. 2021 Mar 24;11(4):487. doi: 10.3390/biom11040487. Biomolecules. 2021. PMID: 33804974 Free PMC article. Review.
Sleep and cardiovascular disease.
Miller MA, Howarth NE. Miller MA, et al. Emerg Top Life Sci. 2023 Dec 22;7(5):457-466. doi: 10.1042/ETLS20230111. Emerg Top Life Sci. 2023. PMID: 38084859 Free PMC article. Review.

Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite - PubMed (original) (raw)