Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha - PubMed (original) (raw)

doi: 10.1016/j.immuni.2004.11.006.

Junko Iwasaki-Arai, Hiromi Iwasaki, Maris L Fenyus, Tajhal Dayaram, Bronwyn M Owens, Hirokazu Shigematsu, Elena Levantini, Claudia S Huettner, Julie A Lekstrom-Himes, Koichi Akashi, Daniel G Tenen

Affiliations

• PMID: 15589173
• DOI: 10.1016/j.immuni.2004.11.006

Free article

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

Pu Zhang et al. Immunity. 2004 Dec.

Free article

Abstract

The transcription factor C/EBP alpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBP alpha blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocyte maturation. C/EBP alpha-deficient hematopoietic stem cells (HSCs) have increased expression of Bmi-1 and enhanced competitive repopulating activity. Bone marrow in adult C/EBP alpha-deficient mice was filled with myeloblasts, similar to human AML, supporting the notion that disruption of C/EBP alpha cooperates with other events in the development of leukemia. Therefore, C/EBP alpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity.

PubMed Disclaimer

Similar articles

• Induction of granulocytic differentiation by 2 pathways.
  Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG. Zhang P, et al. Blood. 2002 Jun 15;99(12):4406-12. doi: 10.1182/blood.v99.12.4406. Blood. 2002. PMID: 12036869
• The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.
  D'Alo' F, Johansen LM, Nelson EA, Radomska HS, Evans EK, Zhang P, Nerlov C, Tenen DG. D'Alo' F, et al. Blood. 2003 Nov 1;102(9):3163-71. doi: 10.1182/blood-2003-02-0479. Epub 2003 Jul 17. Blood. 2003. PMID: 12869508
• Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.
  Porse BT, Bryder D, Theilgaard-Mönch K, Hasemann MS, Anderson K, Damgaard I, Jacobsen SE, Nerlov C. Porse BT, et al. J Exp Med. 2005 Jul 4;202(1):85-96. doi: 10.1084/jem.20050067. Epub 2005 Jun 27. J Exp Med. 2005. PMID: 15983063 Free PMC article.
• Sumoylation and the function of CCAAT enhancer binding protein alpha (C/EBP alpha).
  Khanna-Gupta A. Khanna-Gupta A. Blood Cells Mol Dis. 2008 Jul-Aug;41(1):77-81. doi: 10.1016/j.bcmd.2008.02.011. Epub 2008 Apr 10. Blood Cells Mol Dis. 2008. PMID: 18406180 Free PMC article. Review.
• The role of Trib1 in myeloid leukaemogenesis and differentiation.
  Nakamura T. Nakamura T. Biochem Soc Trans. 2015 Oct;43(5):1104-7. doi: 10.1042/BST20150110. Biochem Soc Trans. 2015. PMID: 26517931 Review.

Cited by

• Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis.
  Tan Q, Wellmerling JH, Song S, Dresler SR, Meridew JA, Choi KM, Li Y, Prakash YS, Tschumperlin DJ. Tan Q, et al. JCI Insight. 2024 Jul 16;9(16):e175290. doi: 10.1172/jci.insight.175290. JCI Insight. 2024. PMID: 39012710 Free PMC article.
• Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms.
  Fernandez SG, Ferguson L, Ingolia NT. Fernandez SG, et al. Life Sci Alliance. 2024 May 21;7(7):e202302501. doi: 10.26508/lsa.202302501. Print 2024 Jul. Life Sci Alliance. 2024. PMID: 38803235 Free PMC article.
• CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair.
  Hassan D, Chen J. Hassan D, et al. Nat Commun. 2024 May 16;15(1):4148. doi: 10.1038/s41467-024-48632-3. Nat Commun. 2024. PMID: 38755149 Free PMC article.
• Transcription factor regulation of ribosomal RNA in hematopoiesis.
  Paralkar VR. Paralkar VR. Curr Opin Hematol. 2024 Jul 1;31(4):199-206. doi: 10.1097/MOH.0000000000000816. Epub 2024 Apr 11. Curr Opin Hematol. 2024. PMID: 38568093 Free PMC article. Review.
• CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair.
  Hassan D, Chen J. Hassan D, et al. Res Sq [Preprint]. 2023 Dec 14:rs.3.rs-3521387. doi: 10.21203/rs.3.rs-3521387/v1. Res Sq. 2023. PMID: 38168395 Free PMC article. Updated. Preprint.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)