Dependence of self-tolerance on TRAF6-directed development of thymic stroma - PubMed (original) (raw)

. 2005 Apr 8;308(5719):248-51.

doi: 10.1126/science.1105677. Epub 2005 Feb 10.

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• PMID: 15705807
• DOI: 10.1126/science.1105677

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Dependence of self-tolerance on TRAF6-directed development of thymic stroma

Taishin Akiyama et al. Science. 2005.

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Abstract

The microenvironments of the thymus are generated by thymic epithelial cells (TECs) and are essential for inducing immune self-tolerance or developing T cells. However, the molecular mechanisms that underlie the differentiation of TECs and thymic compartmentalization are not fully understood. Here we show that deficiency in the tumor necrosis factor receptor-associated factor (TRAF) 6 results in disorganized distribution of medullary TECs (mTECs) and the absence of mature mTECs. Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity. Thus, TRAF6 directs the development of thymic stroma and represents a critical point of regulation for self-tolerance and autoimmunity.

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