Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells - PubMed (original) (raw)

. 1992 Jun 5;256(5062):1448-52.

doi: 10.1126/science.1604321.

Affiliations

• PMID: 1604321
• DOI: 10.1126/science.1604321

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

K L Philpott et al. Science. 1992.

Abstract

Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.

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