A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation - PubMed (original) (raw)
Randomized Controlled Trial
A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
S-M Hongisto et al. Eur J Clin Nutr. 2006 Mar.
Abstract
Objective: The aim of the study was to investigate the effects of fibre-rich rye bread and yoghurt containing Lactobacillus GG (LGG) on intestinal transit time and bowel function, and to test whether they have an interaction in cases of self-reported constipation.
Design: The study was carried out as a two-by-two factorial design.
Setting: Free-living subjects.
Subjects: A total of 59 healthy women with self-reported constipation, recruited by advertisement.
Interventions: After a baseline period, the subjects were randomized into four diet groups: (1) rye bread+LGG yoghurt, (2) rye bread, (3) LGG yoghurt, and (4) control. The 3-week dietary intervention was followed by a 3-week follow-up period. During each period, total intestinal transit time was measured and the subjects recorded faecal frequency and consistency, difficulty in defecation and gastrointestinal symptoms.
Results: The rye bread shortened total intestinal transit time (mean difference, -0.7; CI(95), -1.1 to -0.2; P=0.007), increased faecal frequency (0.3; CI(95), 0.1 to 0.5; P=0.001), softened faeces (-0.3; CI(95), -0.4 to -0.2; P<0.001) and made defecation easier (-0.4; CI(95), -0.5 to -0.2; P<0.001), but also increased gastrointestinal symptoms (1.6; CI(95), 0.7 to 2.4; P<0.001) compared to the low-fibre toast consumed in the LGG and control groups. There were fewer symptoms in the rye bread+LGG group compared to the rye bread group (-1.3; CI(95), -2.4 to -0.2; P=0.027).
Conclusions: Fibre-rich rye bread can be recommended in the treatment of constipation, and the simultaneous consumption of LGG yoghurt relieves the adverse gastrointestinal effects associated with increased intake of fibre.
Sponsorship: Valio Ltd, R&D, and Fazer Bakeries Ltd.
Similar articles
- Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects.
Sairanen U, Piirainen L, Nevala R, Korpela R. Sairanen U, et al. Eur J Clin Nutr. 2007 Dec;61(12):1423-8. doi: 10.1038/sj.ejcn.1602670. Epub 2007 Feb 14. Eur J Clin Nutr. 2007. PMID: 17299467 Clinical Trial. - In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own.
Piirainen L, Kekkonen RA, Kajander K, Ahlroos T, Tynkkynen S, Nevala R, Korpela R. Piirainen L, et al. Ann Nutr Metab. 2008;52(3):204-8. doi: 10.1159/000138124. Epub 2008 Jun 11. Ann Nutr Metab. 2008. PMID: 18544974 Clinical Trial. - A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients.
Castillejo G, Bulló M, Anguera A, Escribano J, Salas-Salvadó J. Castillejo G, et al. Pediatrics. 2006 Sep;118(3):e641-8. doi: 10.1542/peds.2006-0090. Pediatrics. 2006. PMID: 16950955 Clinical Trial. - An overview of the effects of dietary fiber on gastrointestinal transit.
Hillemeier C. Hillemeier C. Pediatrics. 1995 Nov;96(5 Pt 2):997-9. Pediatrics. 1995. PMID: 7494680 Review. - Bran fermentation as a means to enhance technological properties and bioactivity of rye.
Katina K, Laitila A, Juvonen R, Liukkonen KH, Kariluoto S, Piironen V, Landberg R, Aman P, Poutanen K. Katina K, et al. Food Microbiol. 2007 Apr;24(2):175-86. doi: 10.1016/j.fm.2006.07.012. Epub 2006 Sep 12. Food Microbiol. 2007. PMID: 17008162 Review.
Cited by
- Diets for constipation.
Bae SH. Bae SH. Pediatr Gastroenterol Hepatol Nutr. 2014 Dec;17(4):203-8. doi: 10.5223/pghn.2014.17.4.203. Epub 2014 Dec 31. Pediatr Gastroenterol Hepatol Nutr. 2014. PMID: 25587519 Free PMC article. Review. - CSP01, a Novel Superabsorbent Hydrogel, Reduces Colonic Transit Time in Patients With Chronic Idiopathic Constipation in a Randomized, Double-blind, Controlled Pilot Clinical Trial.
Staller K, Barshop K, Vélez C, Bailey A, Locascio JJ, Chiquette E, Kuo B. Staller K, et al. J Neurogastroenterol Motil. 2020 Sep 30;26(4):496-504. doi: 10.5056/jnm20001. J Neurogastroenterol Motil. 2020. PMID: 32807749 Free PMC article. - Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention.
Sarriá B, Martínez-López S, Fernández-Espinosa A, Gómez-Juaristi M, Goya L, Mateos R, Bravo L. Sarriá B, et al. Nutr Metab (Lond). 2012 Apr 18;9:33. doi: 10.1186/1743-7075-9-33. Nutr Metab (Lond). 2012. PMID: 22512838 Free PMC article. - Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Miller LE, Ouwehand AC. Miller LE, et al. World J Gastroenterol. 2013 Aug 7;19(29):4718-25. doi: 10.3748/wjg.v19.i29.4718. World J Gastroenterol. 2013. PMID: 23922468 Free PMC article. Review. - Effects of Lactobacillus plantarum P9 Probiotics on Defecation and Quality of Life of Individuals with Chronic Constipation: Protocol for a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Liu W, Lu NH, Zhou X, Li Y, Xie Y, Zheng L, Zhu W, Xiao Q, Yang N, Zuo K, Wu Q, Xu T, Zhang H. Liu W, et al. Evid Based Complement Alternat Med. 2022 Jun 13;2022:4144321. doi: 10.1155/2022/4144321. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35733625 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical