Effects of a low sodium diet on bone metabolism - PubMed (original) (raw)

Effects of a low sodium diet on bone metabolism

Laura D Carbone et al. J Bone Miner Metab. 2005.

Abstract

Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodium (2-g/day) diet on bone. Forty postmenopausal African-American and Caucasian women were enrolled in a 2-g/day sodium diet for 6 months. Sodium and calcium excretion, bone turnover, and calcitropic hormones (intact parathyroid hormone (PTH) and 1,25 dihydroxyvitamin D) were measured before and 6 months after the intervention. In women who had baseline sodium excretions equal to or greater than the average sodium intake in the United States (> or =3.4 g/day), the low sodium diet resulted in significant decreases in sodium excretion (P = 0.01), in calcium excretion (P = 0.01), and in a biomarker of bone turnover, aminoterminal propeptide of type I collagen (P = 0.04). However, there were no significant changes in calcitropic hormones, including intact PTH (P = 0.97) or 1,25 dihydroxyvitamin D (P = 0.49) with the low sodium diet. These findings suggest that in postmenopausal women with sodium intakes > or =3.4 g/day, a low sodium diet may have benefits for skeletal health.

PubMed Disclaimer

Similar articles

• Effect of high dietary sodium on bone turnover markers and urinary calcium excretion in Korean postmenopausal women with low bone mass.
  Park SM, Joung JY, Cho YY, Sohn SY, Hur KY, Kim JH, Kim SW, Chung JH, Lee MK, Min YK. Park SM, et al. Eur J Clin Nutr. 2015 Mar;69(3):361-6. doi: 10.1038/ejcn.2014.284. Epub 2015 Feb 4. Eur J Clin Nutr. 2015. PMID: 25649239
• The relationship of sodium intake to calcium and sodium excretion and bone mineral density of the hip in postmenopausal African-American and Caucasian women.
  Carbone LD, Bush AJ, Barrow KD, Kang AH. Carbone LD, et al. J Bone Miner Metab. 2003;21(6):415-20. doi: 10.1007/s00774-003-0437-3. J Bone Miner Metab. 2003. PMID: 14586799
• Resistance to bone resorbing effects of PTH in black women.
  Cosman F, Morgan DC, Nieves JW, Shen V, Luckey MM, Dempster DW, Lindsay R, Parisien M. Cosman F, et al. J Bone Miner Res. 1997 Jun;12(6):958-66. doi: 10.1359/jbmr.1997.12.6.958. J Bone Miner Res. 1997. PMID: 9169356
• Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women.
  Teucher B, Dainty JR, Spinks CA, Majsak-Newman G, Berry DJ, Hoogewerff JA, Foxall RJ, Jakobsen J, Cashman KD, Flynn A, Fairweather-Tait SJ. Teucher B, et al. J Bone Miner Res. 2008 Sep;23(9):1477-85. doi: 10.1359/jbmr.080408. J Bone Miner Res. 2008. PMID: 18410231 Clinical Trial.
• Age-related osteoporosis in Chinese: an evaluation of the response of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivation.
  Kung AW, Luk KD, Chu LW, Chiu PK. Kung AW, et al. Am J Clin Nutr. 1998 Dec;68(6):1291-7. doi: 10.1093/ajcn/68.6.1291. Am J Clin Nutr. 1998. PMID: 9846861 Clinical Trial.

Cited by

• Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases.
  Ratajczak AE, Rychter AM, Zawada A, Dobrowolska A, Krela-Kaźmierczak I. Ratajczak AE, et al. Nutrients. 2020 Jun 6;12(6):1702. doi: 10.3390/nu12061702. Nutrients. 2020. PMID: 32517239 Free PMC article. Review.
• Estimation of Prevalence of Osteoporosis Using OSTA and Its Correlation with Sociodemographic Factors, Disability and Comorbidities.
  Wang P, Abdin E, Shafie S, Chong SA, Vaingankar JA, Subramaniam M. Wang P, et al. Int J Environ Res Public Health. 2019 Jul 2;16(13):2338. doi: 10.3390/ijerph16132338. Int J Environ Res Public Health. 2019. PMID: 31269706 Free PMC article.
• Bone turnover after bariatric surgery.
  Melo TL, Froeder L, Baia LDC, Heilberg IP. Melo TL, et al. Arch Endocrinol Metab. 2017 Jul-Aug;61(4):332-336. doi: 10.1590/2359-3997000000279. Epub 2017 Jul 13. Arch Endocrinol Metab. 2017. PMID: 28724055 Free PMC article.
• The relationship between sodium intake and some bone minerals and osteoporosis risk assessment instrument in postmenopausal women.
  Vafa M, Soltani S, Zayeri F, Niroomand M, Najarzadeh A. Vafa M, et al. Med J Islam Repub Iran. 2016 May 28;30:377. eCollection 2016. Med J Islam Repub Iran. 2016. PMID: 27493921 Free PMC article.
• Effect of high dietary sodium on bone turnover markers and urinary calcium excretion in Korean postmenopausal women with low bone mass.
  Park SM, Joung JY, Cho YY, Sohn SY, Hur KY, Kim JH, Kim SW, Chung JH, Lee MK, Min YK. Park SM, et al. Eur J Clin Nutr. 2015 Mar;69(3):361-6. doi: 10.1038/ejcn.2014.284. Epub 2015 Feb 4. Eur J Clin Nutr. 2015. PMID: 25649239

References

1. 1. Diabetes Res Clin Pract. 1998 Apr;39 Suppl:S15-26 - PubMed
2. 1. Br J Nutr. 2004 Jan;91(1):41-51 - PubMed
3. 1. Hypertension. 1996 Mar;27(3 Pt 2):481-90 - PubMed
4. 1. J Nutr. 2003 Oct;133(10):3130-6 - PubMed
5. 1. Med Sci Sports Exerc. 1993 May;25(5):628-42 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Springer