Plasma and liver hepatitis C virus variability in patients coinfected with human immunodeficiency virus - PubMed (original) (raw)

. 2006 May;44(5):1877-80.

doi: 10.1128/JCM.44.5.1877-1880.2006.

Didier Neau, Muriel Faure, Martine Neau, Christophe Martinaud, Elisabeth Legrand, Pascale Trimoulet, Isabelle Garrigue, Brigitte Le Bail, Paulette Bioulac-Sage, Michel Dupon, Jean-Marie Ragnaud, Herve Fleury, Marie-Edith Lafon

Affiliations

• PMID: 16672429
• PMCID: PMC1479191
• DOI: 10.1128/JCM.44.5.1877-1880.2006

Plasma and liver hepatitis C virus variability in patients coinfected with human immunodeficiency virus

Anne-Christine Jouvencel et al. J Clin Microbiol. 2006 May.

Abstract

Liver and plasma hepatitis C virus (HCV) variability was compared by E2 cloning and sequencing in three patients coinfected with HCV and human immunodeficiency virus (HIV) before and after interferon treatment and in three patients solely infected with HCV. The plasma and liver samples contained unique sequences. In the patients coinfected with HIV, accumulated random mutations produced mostly nonsynonymous substitutions in contrast to the reduced HCV genetic variability seen after treatment.

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Figures

FIG. 1.

Comparison of amino acid complexity expressed with Shannon entropy (Sn), between HVR1 and in the flanking regions in HCV-solely infected and HCV-HIV coinfected patients. Mann-Whitney test.

FIG. 2.

Schematic representation of variant repartition in plasma and liver compartments and at baseline (bl) and posttreatment (W72). The numbers of the different variants are in black. The percentage of a variant is indicated in boldface only when it predominates (i.e., >50%).

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