Phosphatidylinositol 4-kinases: old enzymes with emerging functions - PubMed (original) (raw)
Review
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
Andras Balla et al. Trends Cell Biol. 2006 Jul.
Abstract
Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.
Similar articles
- The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.
D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA. D'Angelo G, et al. J Cell Sci. 2008 Jun 15;121(Pt 12):1955-63. doi: 10.1242/jcs.023630. J Cell Sci. 2008. PMID: 18525025 Review. - Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking.
Pendaries C, Tronchère H, Racaud-Sultan C, Gaits-Iacovoni F, Coronas S, Manenti S, Gratacap MP, Plantavid M, Payrastre B. Pendaries C, et al. Adv Enzyme Regul. 2005;45:201-14. doi: 10.1016/j.advenzreg.2005.02.006. Epub 2005 Jul 15. Adv Enzyme Regul. 2005. PMID: 16023705 - Changing phosphoinositides "on the fly": how trafficking vesicles avoid an identity crisis.
Botelho RJ. Botelho RJ. Bioessays. 2009 Oct;31(10):1127-36. doi: 10.1002/bies.200900060. Bioessays. 2009. PMID: 19708025 - Nuclear phosphoinositide kinases and inositol phospholipids.
Gonzales ML, Anderson RA. Gonzales ML, et al. J Cell Biochem. 2006 Feb 1;97(2):252-60. doi: 10.1002/jcb.20655. J Cell Biochem. 2006. PMID: 16267839 Review. - Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease.
Dornan GL, McPhail JA, Burke JE. Dornan GL, et al. Biochem Soc Trans. 2016 Feb;44(1):260-6. doi: 10.1042/BST20150219. Biochem Soc Trans. 2016. PMID: 26862213 Review.
Cited by
- Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation-contraction coupling in ventricular myocytes.
Rhana P, Matsumoto C, Fong Z, Costa AD, Del Villar SG, Dixon RE, Santana LF. Rhana P, et al. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2318535121. doi: 10.1073/pnas.2318535121. Epub 2024 Jun 12. Proc Natl Acad Sci U S A. 2024. PMID: 38865270 Free PMC article. - ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells.
Ajiki M, Yoshikawa M, Miyazaki T, Kawasaki A, Aoki K, Nakatsu F, Tsukiji S. Ajiki M, et al. RSC Chem Biol. 2024 Apr 24;5(6):544-555. doi: 10.1039/d3cb00232b. eCollection 2024 Jun 5. RSC Chem Biol. 2024. PMID: 38846081 Free PMC article. - A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. Kofuji S, et al. Biochem Biophys Res Commun. 2024 Jul 23;718:149981. doi: 10.1016/j.bbrc.2024.149981. Epub 2024 Apr 27. Biochem Biophys Res Commun. 2024. PMID: 38735134 - PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior.
Sang Y, Niu C, Xu J, Zhu T, You S, Wang J, Zhang L, Du X, Zhang H. Sang Y, et al. J Neurosci. 2024 Mar 13;44(11):e0555232024. doi: 10.1523/JNEUROSCI.0555-23.2024. J Neurosci. 2024. PMID: 38267258 Free PMC article. - A Novel Interaction between Chemokine and Phosphoinositide Signaling in Metastatic Prostate Cancer.
Radoiu C, Govindarajan B, Wang M, Sbrissa D, Cher ML, Chinni SR. Radoiu C, et al. Med Res Arch. 2023 Jul;11(7.1):10.18103/mra.v11i7.1.4020. doi: 10.18103/mra.v11i7.1.4020. Epub 2023 Jul 6. Med Res Arch. 2023. PMID: 38239314 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources