Healthy immune response to allergens: T regulatory cells and more - PubMed (original) (raw)

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Healthy immune response to allergens: T regulatory cells and more

Mübeccel Akdis. Curr Opin Immunol. 2006 Dec.

Abstract

The specific immune response to allergens is decisive in the development of clinically healthy or allergic states. In healthy individuals, the B-cell response varies between there being no response and the production of IgG(4)- or IgG(1)-dominating allergen-specific antibodies in the presence or absence of low amounts of IgE. If a detectable immune response is mounted, T regulatory type 1 (Tr1) cells specific for common environmental allergens consistently represent the dominant subset in healthy individuals. Exposure to high doses of allergens leads to a high concentration of specific IgG(4), detectable IgE and a Tr1 type of immune response. Induction of IL-10- and TGF-beta-producing Tr1 cells, IgG(4) isotype blocking antibodies, and suppressed mast cells, basophils and eosinophils represent major components of a relatively normalized immune response after allergen-specific immunotherapy (SIT).

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