A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5 - PubMed (original) (raw)

. 2007 May;132(5):1665-71.

doi: 10.1053/j.gastro.2007.03.034. Epub 2007 Mar 24.

Sheila A Fisher, Andre Franke, Jochen Hampe, Clive M Onnie, Dianne Soars, Richard Bagnall, Muddassar M Mirza, Jeremy Sanderson, Alastair Forbes, John C Mansfield, Cathryn M Lewis, Stefan Schreiber, Christopher G Mathew

Affiliations

• PMID: 17484864
• DOI: 10.1053/j.gastro.2007.03.034

A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5

Natalie J Prescott et al. Gastroenterology. 2007 May.

Abstract

Background & aims: A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.

Methods: The T300A variant (rs2241880) was genotyped in an independent sample of 727 Crohn's disease and 877 ulcerative colitis cases, and in 579 controls. We then performed an extension analysis combining these data with the U.K. data from the initial study to give a total of 1236 U.K. Crohn's disease cases and 1235 controls to estimate disease risk and test for interaction with the CARD15 and IBD5 risk loci and for association with disease subtypes.

Results: The association of T300A was replicated in the independent sample of 727 Crohn's disease cases (P = .001), and was strongly associated in the extended analysis of 1236 Crohn's cases (P = 2.4 x 10(-6)). The 300A/A genotype conferred a 1.65-fold risk of Crohn's disease, with a 2.2-fold risk of ileal disease. Analysis of the interaction of ATG16L1 with CARD15 and IBD5 indicated that all 3 loci contribute independently to disease risk. Homozygosity for the risk allele at all 3 loci conferred a combined risk of 20.4 (95% confidence interval: 8.71, 47.7) for Crohn's disease. The ATG16L1 risk genotype showed a modest but significant association with ulcerative colitis (P = .026).

Conclusions: The association of ATG16L1 with Crohn's disease and possibly with ulcerative colitis supports a role for autophagy in the pathogenesis of inflammatory bowel disease.

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Comment in

• Genome-wide association studies herald a new era of rapid discoveries in inflammatory bowel disease research.
  Duerr RH. Duerr RH. Gastroenterology. 2007 May;132(5):2045-9. doi: 10.1053/j.gastro.2007.03.082. Gastroenterology. 2007. PMID: 17484895 No abstract available.
• ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian population.
  Perricone C, Borgiani P, Romano S, Ciccacci C, Fusco G, Novelli G, Biancone L, Calabrese E, Pallone F. Perricone C, et al. Gastroenterology. 2008 Jan;134(1):368-70. doi: 10.1053/j.gastro.2007.11.017. Gastroenterology. 2008. PMID: 18166373 No abstract available.

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