Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II - PubMed (original) (raw)
Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II
Bruce A Knutson et al. Virus Genes. 2008 Apr.
Abstract
Poxvirus-encoded RNA polymerases were known previously to share extensive sequence homology in their two largest subunits with the corresponding subunits of cellular RNA polymerases and a modest alignment between the smallest poxvirus subunit and RBP10 of RNA polymerase II. The remaining subunits had no apparent cellular homologs. In this study, the HHpred program that combines amino acid sequence alignments with secondary structure predictions was used to search for homologs to the poxvirus RNA polymerase subunits. Significant matches of vaccinia RNA polymerase 22-, 19-, and 18-kDa subunits to RNA polymerase II subunits RPB5, 6, and 7, respectively, were identified. These results strengthen the concept that poxviral RNA polymerases likely evolved from cellular RNA polymerases.
Similar articles
- Evolution of viral DNA-dependent RNA polymerases.
Sonntag KC, Darai G. Sonntag KC, et al. Virus Genes. 1995;11(2-3):271-84. doi: 10.1007/BF01728665. Virus Genes. 1995. PMID: 8828152 Review. - African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.
Yáñez RJ, Boursnell M, Nogal ML, Yuste L, Viñuela E. Yáñez RJ, et al. Nucleic Acids Res. 1993 May 25;21(10):2423-7. doi: 10.1093/nar/21.10.2423. Nucleic Acids Res. 1993. PMID: 8506138 Free PMC article. - Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure.
Mirzakhanyan Y, Gershon PD. Mirzakhanyan Y, et al. Microbiol Mol Biol Rev. 2017 Jul 12;81(3):e00010-17. doi: 10.1128/MMBR.00010-17. Print 2017 Sep. Microbiol Mol Biol Rev. 2017. PMID: 28701329 Free PMC article. Review. - Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases.
Iyer LM, Koonin EV, Aravind L. Iyer LM, et al. BMC Struct Biol. 2003 Jan 28;3:1. doi: 10.1186/1472-6807-3-1. Epub 2003 Jan 28. BMC Struct Biol. 2003. PMID: 12553882 Free PMC article.
Cited by
- RNA Polymerase Mutations Selected during Experimental Evolution Enhance Replication of a Hybrid Vaccinia Virus with an Intermediate Transcription Factor Subunit Replaced by the Myxoma Virus Ortholog.
Stuart CA, Zhivkoplias EK, Senkevich TG, Wyatt LS, Moss B. Stuart CA, et al. J Virol. 2018 Sep 26;92(20):e01089-18. doi: 10.1128/JVI.01089-18. Print 2018 Oct 15. J Virol. 2018. PMID: 30045995 Free PMC article. - Using HHsearch to tackle proteins of unknown function: A pilot study with PH domains.
Fidler DR, Murphy SE, Courtis K, Antonoudiou P, El-Tohamy R, Ient J, Levine TP. Fidler DR, et al. Traffic. 2016 Nov;17(11):1214-1226. doi: 10.1111/tra.12432. Epub 2016 Oct 9. Traffic. 2016. PMID: 27601190 Free PMC article. - Basic mechanism of transcription by RNA polymerase II.
Svetlov V, Nudler E. Svetlov V, et al. Biochim Biophys Acta. 2013 Jan;1829(1):20-8. doi: 10.1016/j.bbagrm.2012.08.009. Epub 2012 Sep 6. Biochim Biophys Acta. 2013. PMID: 22982365 Free PMC article. Review. - Promoter Motifs in NCLDVs: An Evolutionary Perspective.
Oliveira GP, Andrade AC, Rodrigues RA, Arantes TS, Boratto PV, Silva LK, Dornas FP, Trindade GS, Drumond BP, La Scola B, Kroon EG, Abrahão JS. Oliveira GP, et al. Viruses. 2017 Jan 20;9(1):16. doi: 10.3390/v9010016. Viruses. 2017. PMID: 28117683 Free PMC article. Review. - Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus.
Farlow J, Ichou MA, Huggins J, Ibrahim S. Farlow J, et al. Virol J. 2010 May 28;7:110. doi: 10.1186/1743-422X-7-110. Virol J. 2010. PMID: 20509894 Free PMC article.
References
- Science. 2001 Jun 8;292(5523):1876-82 - PubMed
- Cell. 2002 Feb 22;108(4):453-63 - PubMed
- Proc Natl Acad Sci U S A. 1986 May;83(10):3141-5 - PubMed
- J Gen Virol. 2003 Sep;84(Pt 9):2293-2303 - PubMed
- Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases