Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease - PubMed (original) (raw)
Comparative Study
Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease
Marian L Evatt et al. Arch Neurol. 2008 Oct.
Abstract
Background: A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed.
Objective: To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD).
Design: Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine.
Setting: Referral center (PD and AD patients), primary care clinics, and community setting (controls).
Participants: Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n = 97) and control (n = 99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location.
Main outcome measures: Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations.
Results: Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = .02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = .03).
Conclusions: This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.
Figures
Figure
Prevalence of vitamin D insufficiency in patients with Parkinson disease (PD), patients with Alzheimer disease (AD), and matched healthy controls. *_P_=.008 for PD patients vs controls and _P_=.05 for PD patients vs AD patients. †, _P_=.02 for patients with PD vs controls. 25[OH]D indicates 25-hydroxyvitamin D. (To convert 25(OH)D to nanomoles per liter, multiply by 2.496.)
Similar articles
- High prevalence of hypovitaminosis D status in patients with early Parkinson disease.
Evatt ML, DeLong MR, Kumari M, Auinger P, McDermott MP, Tangpricha V; Parkinson Study Group DATATOP Investigators. Evatt ML, et al. Arch Neurol. 2011 Mar;68(3):314-9. doi: 10.1001/archneurol.2011.30. Arch Neurol. 2011. PMID: 21403017 Clinical Trial. - Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis.
Zhao Y, Sun Y, Ji HF, Shen L. Zhao Y, et al. Nutrition. 2013 Jun;29(6):828-32. doi: 10.1016/j.nut.2012.11.018. Epub 2013 Feb 13. Nutrition. 2013. PMID: 23415143 - Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season.
Alemzadeh R, Kichler J, Babar G, Calhoun M. Alemzadeh R, et al. Metabolism. 2008 Feb;57(2):183-91. doi: 10.1016/j.metabol.2007.08.023. Metabolism. 2008. PMID: 18191047 - Vitamin D status and Parkinson's disease: a systematic review and meta-analysis.
Lv Z, Qi H, Wang L, Fan X, Han F, Wang H, Bi S. Lv Z, et al. Neurol Sci. 2014 Nov;35(11):1723-30. doi: 10.1007/s10072-014-1821-6. Epub 2014 May 22. Neurol Sci. 2014. PMID: 24847960 Review. - Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †.
Jayedi A, Rashidy-Pour A, Shab-Bidar S. Jayedi A, et al. Nutr Neurosci. 2019 Nov;22(11):750-759. doi: 10.1080/1028415X.2018.1436639. Epub 2018 Feb 15. Nutr Neurosci. 2019. PMID: 29447107 Review.
Cited by
- Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl/6 Mice.
Doumit M, El-Mallah C, El-Makkawi A, Obeid O, Kobeissy F, Darwish H, Abou-Kheir W. Doumit M, et al. Nutrients. 2024 Sep 2;16(17):2938. doi: 10.3390/nu16172938. Nutrients. 2024. PMID: 39275253 Free PMC article. - Osteoporosis in Parkinson's disease and the role of lean body mass: a cross-sectional study in a Brazilian tertiary center.
Lima DP, Chagas-Neto FAD, Gomes de Luna JR, Martins YO, de Almeida SB, Feitosa CX, Gradvohl LB, Rosa ID, Lopes FKM, Aragão LFF, Viana-Júnior AB, Augusto KL, Roriz-Filho JS, d'Alva CB, Montenegro-Júnior RM, Braga-Neto P. Lima DP, et al. Front Endocrinol (Lausanne). 2024 Apr 22;15:1326212. doi: 10.3389/fendo.2024.1326212. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38711983 Free PMC article. - VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson's disease.
Zheng Z, Chen M, Feng S, Zhao H, Qu T, Zhao X, Ruan Q, Li L, Guo J. Zheng Z, et al. Cell Death Discov. 2024 Mar 21;10(1):150. doi: 10.1038/s41420-024-01912-9. Cell Death Discov. 2024. PMID: 38514643 Free PMC article. - Correlation between 25-hydroxy-vitamin D and Parkinson's disease.
Xia M, Zhou Q. Xia M, et al. IBRO Neurosci Rep. 2023 Oct 16;16:162-167. doi: 10.1016/j.ibneur.2023.02.006. eCollection 2024 Jun. IBRO Neurosci Rep. 2023. PMID: 38318343 Free PMC article. - Do Bone Mineral Density, Trabecular Bone Score, and Hip Structural Analysis Differ in Indian Men with Parkinson's Disease? A Case-Control Pilot Study from a Tertiary Center in Southern India.
Sooragonda BG, Sridharan K, Benjamin RN, Prabhakar AT, Sivadasan A, Kapoor N, Cherian KE, Jebasingh FK, Aaron S, Mathew V, Asha HS, Thomas N, Paul TV. Sooragonda BG, et al. Ann Indian Acad Neurol. 2023 Jul-Aug;26(4):496-501. doi: 10.4103/aian.aian_29_23. Epub 2023 Jul 20. Ann Indian Acad Neurol. 2023. PMID: 37970318 Free PMC article.
References
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. - PubMed
- Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26(5):662–687. - PubMed
- Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr. 2004;80(3):752–758. - PubMed
- Grant WB, Garland CF, Gorham ED. An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day. Recent Results Cancer Res. 2007;174:225–234. - PubMed
- Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007;32(3):210–216. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- K12 RR017643-02/RR/NCRR NIH HHS/United States
- M01 RR00039/RR/NCRR NIH HHS/United States
- M01 RR000039-45/RR/NCRR NIH HHS/United States
- K23 AR054334/AR/NIAMS NIH HHS/United States
- K23 AR054334-02/AR/NIAMS NIH HHS/United States
- U54 ES012068-05/ES/NIEHS NIH HHS/United States
- K12 RR017643-05/RR/NCRR NIH HHS/United States
- M01 RR000039/RR/NCRR NIH HHS/United States
- K12 RR017643/RR/NCRR NIH HHS/United States
- K23 AR054334-01/AR/NIAMS NIH HHS/United States
- P50 AG025688-019001/AG/NIA NIH HHS/United States
- ES012068/ES/NIEHS NIH HHS/United States
- P50 AG025688-02/AG/NIA NIH HHS/United States
- P50 AG025688/AG/NIA NIH HHS/United States
- UL1 TR000454/TR/NCATS NIH HHS/United States
- U54 ES012068-03/ES/NIEHS NIH HHS/United States
- U54 ES012068/ES/NIEHS NIH HHS/United States
- P50AG025688/AG/NIA NIH HHS/United States
- M01 RR000039-40/RR/NCRR NIH HHS/United States
- K23AR054334/AR/NIAMS NIH HHS/United States
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous